Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

por Cowell, Ian G., Austin, Caroline A.
Publicado 2012

Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

por Cowell, Ian G., Austin, Caroline A.
Publicado 2012

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies

por Cowell, Ian G., Austin, Caroline A.
Publicado 2023

To Break or Not to Break: The Role of TOP2B in Transcription

por Cowell, Ian G., Casement, John W., Austin, Caroline A.
Publicado 2023

Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy

por Atwal, Mandeep, Lishman, Emma L., Austin, Caroline A., Cowell, Ian G.
Publicado 2017

Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

por Swan, Rebecca L., Poh, Luke L.K., Cowell, Ian G., Austin, Caroline A.
Publicado 2020

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide

por Sunter, Nicola J., Cowell, Ian G., Willmore, Elaine, Watters, Gary P., Austin, Caroline A.
Publicado 2010

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

por Lee, Ka C., Bramley, Rebecca L., Cowell, Ian G., Jackson, Graham H., Austin, Caroline A.
Publicado 2016

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes

por Lee, Ka Cheong, Swan, Rebecca L., Sondka, Zbyslaw, Padget, Kay, Cowell, Ian G., Austin, Caroline A.
Publicado 2018

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison

por Cowell, Ian G., Ling, Elise M., Swan, Rebecca L., Brooks, Matilda L.W., Austin, Caroline A.
Publicado 2019

Physiotherapists’ Approaches to Patients’ Concerns in Back Pain Consultations Following a Psychologically Informed Training Program

por Cowell, Ian, McGregor, Alison, O’Sullivan, Peter, O’Sullivan, Kieran, Poyton, Ross, Schoeb, Veronika, Murtagh, Ged
Publicado 2021

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation

por Cowell, Ian G., Sunter, Nicola J., Singh, Prim B., Austin, Caroline A., Durkacz, Barbara W., Tilby, Michael J.
Publicado 2007

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193

por Ling, Elise M., Baslé, Arnaud, Cowell, Ian G., van den Berg, Bert, Blower, Tim R., Austin, Caroline A.
Publicado 2022

TOP2B: The First Thirty Years

por Austin, Caroline A., Lee, Ka C., Swan, Rebecca L., Khazeem, Mushtaq M., Manville, Catriona M., Cridland, Peter, Treumann, Achim, Porter, Andrew, Morris, Nick J., Cowell, Ian G.
Publicado 2018

TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells

por Khazeem, Mushtaq M., Casement, John W., Schlossmacher, George, Kenneth, Niall S., Sumbung, Nielda K., Chan, Janice Yuen Tung, McGow, Jade F., Cowell, Ian G., Austin, Caroline A.
Publicado 2022

Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells

por Manville, Catriona M., Smith, Kayleigh, Sondka, Zbyslaw, Rance, Holly, Cockell, Simon, Cowell, Ian G., Lee, Ka Cheong, Morris, Nicholas J., Padget, Kay, Jackson, Graham H., Austin, Caroline A.
Publicado 2015

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

por Lee, Ka Cheong, Padget, Kay, Curtis, Hannah, Cowell, Ian G., Moiani, Davide, Sondka, Zbyslaw, Morris, Nicholas J., Jackson, Graham H., Cockell, Simon J., Tainer, John A., Austin, Caroline A.
Publicado 2012

Two type I topoisomerases maintain DNA topology in human mitochondria

por Menger, Katja E, Chapman, James, Díaz-Maldonado, Héctor, Khazeem, Mushtaq M, Deen, Dasha, Erdinc, Direnis, Casement, John W, Di Leo, Valeria, Pyle, Angela, Rodríguez-Luis, Alejandro, Cowell, Ian G, Falkenberg, Maria, Austin, Caroline A, Nicholls, Thomas J
Publicado 2022

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons

por Best, Andrew, James, Katherine, Dalgliesh, Caroline, Hong, Elaine, Kheirolahi-Kouhestani, Mahsa, Curk, Tomaz, Xu, Yaobo, Danilenko, Marina, Hussain, Rafiq, Keavney, Bernard, Wipat, Anil, Klinck, Roscoe, Cowell, Ian G., Cheong Lee, Ka, Austin, Caroline A., Venables, Julian P., Chabot, Benoit, Santibanez Koref, Mauro, Tyson-Capper, Alison, Elliott, David J.
Publicado 2014

Mutations in topoisomerase IIβ result in a B cell immunodeficiency

por Broderick, Lori, Yost, Shawn, Li, Dong, McGeough, Matthew D., Booshehri, Laela M., Guaderrama, Marisela, Brydges, Susannah D., Kucharova, Karolina, Patel, Niraj C., Harr, Margaret, Hakonarson, Hakon, Zackai, Elaine, Cowell, Ian G., Austin, Caroline A., Hügle, Boris, Gebauer, Corinna, Zhang, Jianguo, Xu, Xun, Wang, Jian, Croker, Ben A., Frazer, Kelly A., Putnam, Christopher D., Hoffman, Hal M.
Publicado 2019