Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex

por Adams, Grace E., Chandru, Aditya, Cowley, Shaun M.
Publicado 2018

Bifunctional HDAC Therapeutics: One Drug to Rule Them All?

por Smalley, Joshua P., Cowley, Shaun M., Hodgkinson, James T.
Publicado 2020

Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription

por Barnes, Claire E., English, David M., Cowley, Shaun M.
Publicado 2019

Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice

por Dovey, Oliver M, Vasilliou, George, Bradley, Allan, Cowley, Shaun M
Publicado 2013

Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain

por Chandru, Aditya, Bate, Neil, Vuister, Geerten W., Cowley, Shaun M.
Publicado 2018

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation

por Barnes, Claire E., English, David M., Broderick, Megan, Collins, Mark O., Cowley, Shaun M.
Publicado 2021

Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs)

por Baker, India M., Smalley, Joshua P., Sabat, Khadija A., Hodgkinson, James T., Cowley, Shaun M.
Publicado 2022

Subcloning Plus Insertion (SPI) - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors

por Reddy, Thimma R., Kelsall, Emma J., Fevat, Léna M.S., Munson, Sarah E., Cowley, Shaun M.
Publicado 2015

Lambda Red Mediated Gap Repair Utilizes a Novel Replicative Intermediate in Escherichia coli

por Reddy, Thimma R., Fevat, Léna M. S., Munson, Sarah E., Stewart, A. Francis, Cowley, Shaun M.
Publicado 2015

Differential Requirements of Singleplex and Multiplex Recombineering of Large DNA Constructs

por Reddy, Thimma R., Kelsall, Emma J., Fevat, Léna M. S., Munson, Sarah E., Cowley, Shaun M.
Publicado 2015

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition

por Thambyrajah, Roshana, Fadlullah, Muhammad Z.H., Proffitt, Martin, Patel, Rahima, Cowley, Shaun M., Kouskoff, Valerie, Lacaud, Georges
Publicado 2018

A ‘click’ chemistry approach to novel entinostat (MS-275) based class I histone deacetylase proteolysis targeting chimeras

por Cross, Jasmine M., Coulson, Megan E., Smalley, Joshua P., Pytel, Wiktoria A., Ismail, Ozair, Trory, Justin S., Cowley, Shaun M., Hodgkinson, James T.
Publicado 2022

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

por Millard, Christopher J., Watson, Peter J., Celardo, Ivana, Gordiyenko, Yuliya, Cowley, Shaun M., Robinson, Carol V., Fairall, Louise, Schwabe, John W.R.
Publicado 2013

Recombinant Protein Expression for Structural Biology in HEK 293F Suspension Cells: A Novel and Accessible Approach

por Portolano, Nicola, Watson, Peter J., Fairall, Louise, Millard, Christopher J., Milano, Charles P., Song, Yun, Cowley, Shaun M., Schwabe, John W.R.
Publicado 2014

Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells

por Smalley, Joshua P., Baker, India M., Pytel, Wiktoria A., Lin, Li-Ying, Bowman, Karen J., Schwabe, John W. R., Cowley, Shaun M., Hodgkinson, James T.
Publicado 2022

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

por Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.
Publicado 2016

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

por Turnbull, Robert E., Fairall, Louise, Saleh, Almutasem, Kelsall, Emma, Morris, Kyle L., Ragan, T. J., Savva, Christos G., Chandru, Aditya, Millard, Christopher J., Makarova, Olga V., Smith, Corinne J., Roseman, Alan M., Fry, Andrew M., Cowley, Shaun M., Schwabe, John W. R.
Publicado 2020