Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections

por Addison, William, Frederickson, Martyn, Coyne, Anthony G., Abell, Chris
Publicado 2022

Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases

por Scott, Duncan E, Coyne, Anthony G, Venkitaraman, Ashok, Blundell, Tom L, Abell, Chris, Hyvönen, Marko
Publicado 2015

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121

por Hudson, Sean A., Surade, Sachin, Coyne, Anthony G., McLean, Kirsty J., Leys, David, Munro, Andrew W., Abell, Chris
Publicado 2013

Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis

por Trapero, Ana, Pacitto, Angela, Singh, Vinayak, Sabbah, Mohamad, Coyne, Anthony G., Mizrahi, Valerie, Blundell, Tom L., Ascher, David B., Abell, Chris
Publicado 2018

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

por Kavanagh, Madeline E., Gray, Janine L., Gilbert, Sophie H., Coyne, Anthony G., McLean, Kirsty J., Davis, Holly J., Munro, Andrew W., Abell, Chris
Publicado 2016

Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

por Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G., Dias, David M. G., Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris
Publicado 2020

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

por Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G., Dias, David M. G., Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris
Publicado 2020

Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping

por Thomas, Sherine E., Collins, Patrick, James, Rory Hennell, Mendes, Vitor, Charoensutthivarakul, Sitthivut, Radoux, Chris, Abell, Chris, Coyne, Anthony G., Floto, R. Andres, von Delft, Frank, Blundell, Tom L.
Publicado 2019

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

por Thomas, Sherine E., McCarthy, William J., El Bakali, Jamal, Brown, Karen P., Kim, So Yeon, Blaszczyk, Michal, Mendes, Vítor, Abell, Chris, Floto, R. Andres, Coyne, Anthony G., Blundell, Tom L.
Publicado 2022

Development of Inhibitors against Mycobacterium abscessus tRNA (m(1)G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

por Whitehouse, Andrew J., Thomas, Sherine E., Brown, Karen P., Fanourakis, Alexander, Chan, Daniel S.-H., Libardo, M. Daben J., Mendes, Vitor, Boshoff, Helena I. M., Floto, R. Andres, Abell, Chris, Blundell, Tom L., Coyne, Anthony G.
Publicado 2019

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

por Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Publicado 2016

A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

por Gupta, Pooja, Thomas, Sherine E., Zaidan, Shaymaa A., Pasillas, Maria A., Cory-Wright, James, Sebastián-Pérez, Víctor, Burgess, Ailidh, Cattermole, Emma, Meghir, Clio, Abell, Chris, Coyne, Anthony G., Jacobs, William R., Blundell, Tom L., Tiwari, Sangeeta, Mendes, Vítor
Publicado 2021

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

por Chenge, Jude T., Duyet, Le Van, Swami, Shalini, McLean, Kirsty J., Kavanagh, Madeline E., Coyne, Anthony G., Rigby, Stephen E. J., Cheesman, Myles R., Girvan, Hazel M., Levy, Colin W., Rupp, Bernd, von Kries, Jens P., Abell, Chris, Leys, David, Munro, Andrew W.
Publicado 2017

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening app...

por Frederickson, Martyn, Selvam, Irwin R., Evangelopoulos, Dimitrios, McLean, Kirsty J., Katariya, Mona M., Tunnicliffe, Richard B., Campbell, Bethany, Kavanagh, Madeline E., Charoensutthivarakul, Sitthivut, Blankley, Richard T., Levy, Colin W., de Carvalho, Luiz Pedro S., Leys, David, Munro, Andrew W., Coyne, Anthony G., Abell, Chris
Publicado 2022

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

por Thomas, Sherine E, Whitehouse, Andrew J, Brown, Karen, Burbaud, Sophie, Belardinelli, Juan M, Sangen, Jasper, Lahiri, Ramanuj, Libardo, Mark Daben J, Gupta, Pooja, Malhotra, Sony, Boshoff, Helena I M, Jackson, Mary, Abell, Chris, Coyne, Anthony G, Blundell, Tom L, Floto, Rodrigo Andres, Mendes, Vítor
Publicado 2020

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity

por Evans, Joanna C., Murugesan, Dinakaran, Post, John M., Mendes, Vitor, Wang, Zhe, Nahiyaan, Navid, Lynch, Sasha L., Thompson, Stephen, Green, Simon R., Ray, Peter C., Hess, Jeannine, Spry, Christina, Coyne, Anthony G., Abell, Chris, Boshoff, Helena I. M., Wyatt, Paul G., Rhee, Kyu Y., Blundell, Tom L., Barry, Clifton E., Mizrahi, Valerie
Publicado 2021

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

por Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., Abell, Chris
Publicado 2021

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

por Mendes, Vitor, Green, Simon R., Evans, Joanna C., Hess, Jeannine, Blaszczyk, Michal, Spry, Christina, Bryant, Owain, Cory-Wright, James, Chan, Daniel S-H., Torres, Pedro H. M., Wang, Zhe, Nahiyaan, Navid, O’Neill, Sandra, Damerow, Sebastian, Post, John, Bayliss, Tracy, Lynch, Sasha L., Coyne, Anthony G., Ray, Peter C., Abell, Chris, Rhee, Kyu Y., Boshoff, Helena I. M., Barry, Clifton E., Mizrahi, Valerie, Wyatt, Paul G., Blundell, Tom L.
Publicado 2021