ORACLE reveals a bright future to fight bacteria

por Coyote-Maestas, Willow, Fraser, James S
Publicado 2021

Determinants of trafficking, conduction, and disease within a K(+) channel revealed through multiparametric deep mutational scanning

por Coyote-Maestas, Willow, Nedrud, David, He, Yungui, Schmidt, Daniel
Publicado 2022

Domain insertion permissibility-guided engineering of allostery in ion channels

por Coyote-Maestas, Willow, He, Yungui, Myers, Chad L., Schmidt, Daniel
Publicado 2019

Targeted insertional mutagenesis libraries for deep domain insertion profiling

por Coyote-Maestas, Willow, Nedrud, David, Okorafor, Steffan, He, Yungui, Schmidt, Daniel
Publicado 2020

Targeted insertional mutagenesis libraries for deep domain insertion profiling

por Coyote-Maestas, Willow, Nedrud, David, Okorafor, Steffan, He, Yungui, Schmidt, Daniel
Publicado 2020

DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology

por Macdonald, Christian B., Nedrud, David, Grimes, Patrick Rockefeller, Trinidad, Donovan, Fraser, James S., Coyote-Maestas, Willow
Publicado 2023

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

por Coyote-Maestas, Willow, Nedrud, David, Suma, Antonio, He, Yungui, Matreyek, Kenneth A., Fowler, Douglas M., Carnevale, Vincenzo, Myers, Chad L., Schmidt, Daniel
Publicado 2021

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

por Estevam, Gabriella O., Linossi, Edmond M., Macdonald, Christian B., Espinoza, Carla A., Michaud, Jennifer M., Coyote-Maestas, Willow, Collisson, Eric A., Jura, Natalia, Fraser, James S.
Publicado 2023

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

por Yee, Sook Wah, Macdonald, Christian, Mitrovic, Darko, Zhou, Xujia, Koleske, Megan L., Yang, Jia, Silva, Dina Buitrago, Grimes, Patrick Rockefeller, Trinidad, Donovan, More, Swati S., Kachuri, Linda, Witte, John S., Delemotte, Lucie, Giacomini, Kathleen M., Coyote-Maestas, Willow
Publicado 2023