ACE-domain selectivity extends beyond direct interacting residues at the active site

por Cozier, Gyles E., Lubbe, Lizelle, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2020

Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

por Sharma, Urvashi, Cozier, Gyles E., Sturrock, Edward D., Acharya, K. Ravi
Publicado 2020

Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics

por Cozier, Gyles E., Lubbe, Lizelle, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2020

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

por Lubbe, Lizelle, Cozier, Gyles E., Oosthuizen, Delia, Acharya, K. Ravi, Sturrock, Edward D.
Publicado 2020

Crystal structure of a peptidyl‐dipeptidase K‐26‐DCP from Actinomycete in complex with its natural inhibitor

por Masuyer, Geoffrey, Cozier, Gyles E., Kramer, Glenna J., Bachmann, Brian O., Acharya, K. Ravi
Publicado 2016

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosph...

por Mills, Stephen J., Silvander, Camilla, Cozier, Gyles, Trésaugues, Lionel, Nordlund, Pär, Potter, Barry V. L.
Publicado 2016

Crystal structures of sampatrilat and sampatrilat‐Asp in complex with human ACE – a molecular basis for domain selectivity

por Cozier, Gyles E., Schwager, Sylva L., Sharma, Rajni K., Chibale, Kelly, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2018

Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat

por Cozier, Gyles E., Newby, Emma C., Schwager, Sylva L. U., Isaac, R. Elwyn, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2022

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

por Abu Hasan, Zatul-’Iffah, Williams, Helen, Ismail, Nur M., Othman, Hidayatulfathi, Cozier, Gyles E., Acharya, K. Ravi, Isaac, R. Elwyn
Publicado 2017

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

por Mills, Stephen J., Persson, Camilla, Cozier, Gyles, Thomas, Mark P., Trésaugues, Lionel, Erneux, Christophe, Riley, Andrew M., Nordlund, Pär, Potter, Barry V. L.
Publicado 2012

Instant Detection of Synthetic Cannabinoids on Physical Matrices, Implemented on a Low-Cost, Ultraportable Device

por Cozier, Gyles E., Andrews, Rachael C., Frinculescu, Anca, Kumar, Ranjeet, May, Benedict, Tooth, Tom, Collins, Peter, Costello, Andrew, Haines, Tom S. F., Freeman, Tom P., Blagbrough, Ian S., Scott, Jennifer, Shine, Trevor, Sutcliffe, Oliver B., Husbands, Stephen M., Leach, Jonathan, Bowman, Richard W., Pudney, Christopher R.
Publicado 2023

Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; toward Robust Point-of-Care Detection

por Andrews, Rachael C., May, Benedict, Hernández, Federico J., Cozier, Gyles E., Townsend, Piers A., Sutcliffe, Oliver B., Haines, Tom S. F., Freeman, Tom P., Scott, Jennifer, Husbands, Stephen M., Blagbrough, Ian S., Bowman, Richard W., Lewis, Simon E., Grayson, Matthew N., Crespo-Otero, Rachel, Carbery, David R., Pudney, Christopher R.
Publicado 2023

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein*

por Sacerdoti, Mariana, Gross, Lissy Z.F., Riley, Andrew M., Zehnder, Karin, Ghode, Abhijeet, Klinke, Sebastián, Anand, Ganesh Srinivasan, Paris, Kristina, Winkel, Angelika, Herbrand, Amanda, Godage, H. Yasmin, Cozier, Gyles E., Süß, Evelyn, Schulze, Jörg O., Pastor-Flores, Daniel, Bollini, Mariela, Cappellari, María Victoria, Svergun, Dmitri, Gräwert, Melissa A., Aramendia, Pedro F., Leroux, Alejandro E., Potter, Barry V.L., Camacho, Carlos J., Biondi, Ricardo M.
Publicado 2023