Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

por Kadoch, Cigall, Crabtree, Gerald R.
Publicado 2015

esBAF Facilitates Pluripotency by Conditioning the Genome for LIF/STAT3Signalingand by Regulating Polycomb Function

por Ho, Lena, Miller, Erik L., Ronan, Jehnna L., Ho, Wenqi, Jothi, Raja, Crabtree, Gerald R
Publicado 2011

Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer

por Seoane, Jose A., Kirkland, Jacob G., Caswell-Jin, Jennifer L., Crabtree, Gerald R., Curtis, Christina
Publicado 2019

Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

por Hagihara, Hideo, Shoji, Hirotaka, Kuroiwa, Mahomi, Graef, Isabella A., Crabtree, Gerald R., Nishi, Akinori, Miyakawa, Tsuyoshi
Publicado 2022

Rapid and reversible epigenome editing by endogenous chromatin regulators

por Braun, Simon M. G., Kirkland, Jacob G., Chory, Emma J., Husmann, Dylan, Calarco, Joseph P., Crabtree, Gerald R.
Publicado 2017

BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex

por Braun, Simon M.G., Petrova, Ralitsa, Tang, Jiong, Krokhotin, Andrey, Miller, Erik L., Tang, Yitai, Panagiotakos, Georgia, Crabtree, Gerald R.
Publicado 2021

Rapid chromatin repression by Aire provides precise control of immune tolerance

por Koh, Andrew S., Miller, Erik L., Buenrostro, Jason D., Moskowitz, David M., Wang, Jing, Greenleaf, William J., Chang, Howard Y., Crabtree, Gerald R.
Publicado 2018

LSH mediates gene repression through macroH2A deposition

por Ni, Kai, Ren, Jianke, Xu, Xiaoping, He, Yafeng, Finney, Richard, Braun, Simon M. G., Hathaway, Nathaniel A., Crabtree, Gerald R., Muegge, Kathrin
Publicado 2020

mSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIα

por Dykhuizen, Emily C., Hargreaves, Diana C., Miller, Erik, Cui, Kairong, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan, Cho, Yoon-Jae, Zhao, Keji, Crabtree, Gerald R.
Publicado 2013

Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States

por Kadoch, Cigall, Williams, Robert T., Calarco, Joseph P., Miller, Erik L., Weber, Christopher M., Braun, Simon G., Pulice, John L., Chory, Emma J., Crabtree, Gerald R.
Publicado 2016

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

por Morrison, Emma A., Sanchez, Julio C., Ronan, Jehnna L., Farrell, Daniel P., Varzavand, Katayoun, Johnson, Jenna K., Gu, Brian X., Crabtree, Gerald R., Musselman, Catherine A.
Publicado 2017

Dominant-negative SMARCA4 missense mutations alter the accessibility landscape of tissue-unrestricted enhancers

por Hodges, H. Courtney, Stanton, Benjamin Z., Cermakova, Katerina, Chang, Chiung-Ying, Miller, Erik L., Kirkland, Jacob G., Ku, Wai Lim, Veverka, Vaclav, Zhao, Keji, Crabtree, Gerald R.
Publicado 2017

The Interaction of SWI/SNF with the Ribosome Regulates Translation and Confers Sensitivity to Translation Pathway Inhibitors in Cancers with Complex Perturbations

por Ulicna, Livia, Kimmey, Samuel C., Weber, Christopher M., Allard, Grace M., Wang, Aihui, Bui, Nam Q., Bendall, Sean C., Crabtree, Gerald R., Bean, Gregory R., Van Rechem, Capucine
Publicado 2022

TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin

por Miller, Erik L., Hargreaves, Diana C., Kadoch, Cigall, Chang, Chiung-Ying, Calarco, Joseph P., Hodges, Courtney, Buenrostro, Jason D., Cui, Kairong, Greenleaf, William J., Zhao, Keji, Crabtree, Gerald R.
Publicado 2017

Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains

por Takebayashi, Shin-ichiro, Lei, Ienglam, Ryba, Tyrone, Sasaki, Takayo, Dileep, Vishnu, Battaglia, Dana, Gao, Xiaolin, Fang, Peng, Fan, Yong, Esteban, Miguel A, Tang, Jiong, Crabtree, Gerald R, Wang, Zhong, Gilbert, David M
Publicado 2013

ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve

por Park, Hye-Jin, Tsai, Eric, Huang, Dennis, Weaver, Michael, Frick, Luciana, Alcantara, Ace, Moran, John J., Patzig, Julia, Melendez-Vasquez, Carmen V., Crabtree, Gerald R., Feltri, M.L., Svaren, John, Casaccia, Patrizia
Publicado 2022

Exome sequencing to identify de novo mutations in sporadic ALS trios

por Chesi, Alessandra, Staahl, Brett T., Jovicic, Ana, Couthouis, Julien, Fasolino, Maria, Raphael, Alya R., Yamazaki, Tomohiro, Elias, Laura, Polak, Meraida, Kelly, Crystal, Williams, Kelly L., Fifita, Jennifer A., Maragakis, Nicholas J., Nicholson, Garth A., King, Oliver D., Reed, Robin, Crabtree, Gerald R., Blair, Ian P., Glass, Jonathan D., Gitler, Aaron D.
Publicado 2013

The Neuron-specific Chromatin Regulatory Subunit BAF53b is Necessary for Synaptic Plasticity and Memory

por Vogel-Ciernia, Annie, Matheos, Dina P., Barrett, Ruth M., Kramár, Enikö, Azzawi, Soraya, Chen, Yuncai, Magnan, Christophe N., Zeller, Michael, Sylvain, Angelina, Haettig, Jakob, Jia, Yousheng, Tran, Anthony, Dang, Richard, Post, Rebecca J., Chabrier, Meredith, Babayan, Alex, Wu, Jiang I., Crabtree, Gerald R., Baldi, Pierre, Baram, Tallie Z., Lynch, Gary, Wood, Marcelo A.
Publicado 2013

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

por Fulton, Sasha L., Wenderski, Wendy, Lepack, Ashley E., Eagle, Andrew L., Fanutza, Tomas, Bastle, Ryan M., Ramakrishnan, Aarthi, Hays, Emma C., Neal, Arianna, Bendl, Jaroslav, Farrelly, Lorna A., Al-Kachak, Amni, Lyu, Yang, Cetin, Bulent, Chan, Jennifer C., Tran, Tina N., Neve, Rachael L., Roper, Randall J., Brennand, Kristen J., Roussos, Panos, Schimenti, John C., Friedman, Allyson K., Shen, Li, Blitzer, Robert D., Robison, Alfred J., Crabtree, Gerald R., Maze, Ian
Publicado 2022

Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism

por Wenderski, Wendy, Wang, Lu, Krokhotin, Andrey, Walsh, Jessica J., Li, Hongjie, Shoji, Hirotaka, Ghosh, Shereen, George, Renee D., Miller, Erik L., Elias, Laura, Gillespie, Mark A., Son, Esther Y., Staahl, Brett T., Baek, Seung Tae, Stanley, Valentina, Moncada, Cynthia, Shipony, Zohar, Linker, Sara B., Marchetto, Maria C. N., Gage, Fred H., Chen, Dillon, Sultan, Tipu, Zaki, Maha S., Ranish, Jeffrey A., Miyakawa, Tsuyoshi, Luo, Liqun, Malenka, Robert C., Crabtree, Gerald R., Gleeson, Joseph G.
Publicado 2020