Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling

por Alkaitis, Matthew S., Crabtree, Mark J.
Publicado 2012

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

por Crabtree, Mark J., Hale, Ashley B., Channon, Keith M.
Publicado 2011

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

por Diotallevi, Marina, Ayaz, Faseeha, Nicol, Thomas, Crabtree, Mark J.
Publicado 2021

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

por Crabtree, Mark J., Brixey, Rachel, Batchelor, Helen, Hale, Ashley B., Channon, Keith M.
Publicado 2013

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice

por Chuaiphichai, Surawee, Crabtree, Mark J, Mcneill, Eileen, Hale, Ashley B, Trelfa, Lucy, Channon, Keith M, Douglas, Gillian
Publicado 2017

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE(−/−) mice

por Douglas, Gillian, Bendall, Jennifer K., Crabtree, Mark J., Tatham, Amy L., Carter, Emma E., Hale, Ashley B., Channon, Keith M.
Publicado 2012

Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide

por Kalla, Manish, Chotalia, Minesh, Coughlan, Charles, Hao, Guoliang, Crabtree, Mark J., Tomek, Jakub, Bub, Gil, Paterson, David J., Herring, Neil
Publicado 2016

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION

por Benson, Matthew A., Batchelor, Helen, Chuaiphichai, Surawee, Bailey, Jade, Zhu, Hanneng, Stuehr, Dennis J., Bhattacharya, Shoumo, Channon, Keith M., Crabtree, Mark J.
Publicado 2013

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

por McNeill, Eileen, Crabtree, Mark J., Sahgal, Natasha, Patel, Jyoti, Chuaiphichai, Surawee, Iqbal, Asif J., Hale, Ashley B., Greaves, David R., Channon, Keith M.
Publicado 2015

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

por Bailey, Jade, Shaw, Andrew, Fischer, Roman, Ryan, Brent J., Kessler, Benedikt M., McCullagh, James, Wade-Martins, Richard, Channon, Keith M., Crabtree, Mark J.
Publicado 2017

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology

por Bailey, Jade D., Shaw, Andrew, McNeill, Eileen, Nicol, Thomas, Diotallevi, Marina, Chuaiphichai, Surawee, Patel, Jyoti, Hale, Ashley, Channon, Keith M., Crabtree, Mark J.
Publicado 2020

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury

por Chuaiphichai, Surawee, Chu, Sandy M., Carnicer, Ricardo, Kelly, Matthew, Bendall, Jenifer K., Simon, Jillian N., Douglas, Gillian, Crabtree, Mark J., Casadei, Barbara, Channon, Keith M.
Publicado 2023

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

por Douglas, Gillian, Hale, Ashley B., Crabtree, Mark J, Ryan, Brent J., Hansler, Alex, Watschinger, Katrin, Gross, Steven S, Lygate, Craig A., Alp, Nicholas J., Channon, Keith M.
Publicado 2015

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

por Douglas, Gillian, Hale, Ashley B, Patel, Jyoti, Chuaiphichai, Surawee, Al Haj Zen, Ayman, Rashbrook, Victoria S, Trelfa, Lucy, Crabtree, Mark J, McNeill, Eileen, Channon, Keith M
Publicado 2018

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1

por Richards, Mark A, Simon, Jillian N, Ma, Ruichong, Loonat, Aminah A, Crabtree, Mark J, Paterson, David J, Fahlman, Richard P, Casadei, Barbara, Fliegel, Larry, Swietach, Pawel
Publicado 2019

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification

por Douglas, Gillian, Van Kampen, Erik, Hale, Ashley B., McNeill, Eileen, Patel, Jyoti, Crabtree, Mark J., Ali, Ziad, Hoerr, Robert A., Alp, Nicholas J., Channon, Keith M.
Publicado 2013

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

por Bailey, Jade, Davis, Simon, Shaw, Andrew, Diotallevi, Marina, Fischer, Roman, Benson, Matthew A., Zhu, Hanneng, Brown, James, Bhattacharya, Shoumo, Kessler, Benedikt M., Channon, Keith M., Crabtree, Mark J.
Publicado 2018

Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor

por Vidanapathirana, Achini K., Goyne, Jarrad M., Williamson, Anna E., Pullen, Benjamin J., Chhay, Pich, Sandeman, Lauren, Bensalem, Julien, Sargeant, Timothy J., Grose, Randall, Crabtree, Mark J., Zhang, Run, Nicholls, Stephen J., Psaltis, Peter J., Bursill, Christina A.
Publicado 2022

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

por Bailey, Jade D., Diotallevi, Marina, Nicol, Thomas, McNeill, Eileen, Shaw, Andrew, Chuaiphichai, Surawee, Hale, Ashley, Starr, Anna, Nandi, Manasi, Stylianou, Elena, McShane, Helen, Davis, Simon, Fischer, Roman, Kessler, Benedikt M., McCullagh, James, Channon, Keith M., Crabtree, Mark J.
Publicado 2019

Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: a randomized trial of atorvastatin

por Jayaram, Raja, Jones, Michael, Reilly, Svetlana, Crabtree, Mark J, Pal, Nikhil, Goodfellow, Nicola, Nahar, Keshav, Simon, Jillian, Carnicer, Ricardo, DeSilva, Ravi, Ratnatunga, Chandana, Petrou, Mario, Sayeed, Rana, Roalfe, Andrea, Channon, Keith M, Bashir, Yaver, Betts, Timothy, Hill, Michael, Casadei, Barbara
Publicado 2020