Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp(3))–H functionalization of amines

por Idiris, Fahima I. M., Majesté, Cécile E., Craven, Gregory B., Jones, Christopher R.
Publicado 2018

Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A

por Liu, Yixin, De Castro Ribeiro, Orquidea, Haapanen, Outi, Craven, Gregory B., Sharma, Vivek, Muench, Stephen P., Goldman, Adrian
Publicado 2022

High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery

por Craven, Gregory B., Affron, Dominic P., Allen, Charlotte E., Matthies, Stefan, Greener, Joe G., Morgan, Rhodri M. L., Tate, Edward W., Armstrong, Alan, Mann, David J.
Publicado 2018

Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT)

por Craven, Gregory B., Affron, Dominic P., Kösel, Teresa, Wong, Tsz Lam M., Jukes, Zoë H., Liu, Chun‐Ting, Morgan, Rhodri M. L., Armstrong, Alan, Mann, David J.
Publicado 2020

Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity

por Alguel, Yilmaz, Amillis, Sotiris, Leung, James, Lambrinidis, George, Capaldi, Stefano, Scull, Nicola J., Craven, Gregory, Iwata, So, Armstrong, Alan, Mikros, Emmanuel, Diallinas, George, Cameron, Alexander D., Byrne, Bernadette
Publicado 2016

Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease

por Qin, Bo, Craven, Gregory B., Hou, Pengjiao, Chesti, Julian, Lu, Xinran, Child, Emma S., Morgan, Rhodri M.L., Niu, Wenchao, Zhao, Lina, Armstrong, Alan, Mann, David J., Cui, Sheng
Publicado 2022

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A

por Jamshidiha, Mostafa, Lanyon-Hogg, Thomas, Sutherell, Charlotte L., Craven, Gregory B., Tersa, Montse, De Vita, Elena, Brustur, Delia, Pérez-Dorado, Inmaculada, Hassan, Sarah, Petracca, Rita, Morgan, Rhodri M., Sanz-Hernández, Máximo, Norman, Jim C., Armstrong, Alan, Mann, David J., Cota, Ernesto, Tate, Edward W.
Publicado 2021

Signal peptide mimicry primes Sec61 for client-selective inhibition

por Rehan, Shahid, Tranter, Dale, Sharp, Phillip P., Craven, Gregory B., Lowe, Eric, Anderl, Janet L., Muchamuel, Tony, Abrishami, Vahid, Kuivanen, Suvi, Wenzell, Nicole A., Jennings, Andy, Kalyanaraman, Chakrapani, Strandin, Tomas, Javanainen, Matti, Vapalahti, Olli, Jacobson, Matthew P., McMinn, Dustin, Kirk, Christopher J., Huiskonen, Juha T., Taunton, Jack, Paavilainen, Ville O.
Publicado 2023