The role of Ubiquitination in Apoptosis and Necroptosis

por Roberts, Jamie Z., Crawford, Nyree, Longley, Daniel B.
Publicado 2021

Dynamical Systems Analysis of Mitochondrial BAK Activation Kinetics Predicts Resistance to BH3 Domains

por Grills, Claire, Crawford, Nyree, Chacko, Alex, Johnston, Patrick G., O'Rourke, Francesca, Fennell, Dean A.
Publicado 2008

Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)

por Salvucci, Manuela, Crawford, Nyree, Stott, Katie, Bullman, Susan, Longley, Daniel B, Prehn, Jochen H M
Publicado 2022

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

por Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria
Publicado 2020

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant

por Fichtner, Michael, Bozkurt, Emir, Salvucci, Manuela, McCann, Christopher, McAllister, Katherine A., Halang, Luise, Düssmann, Heiko, Kinsella, Sinéad, Crawford, Nyree, Sessler, Tamas, Longley, Daniel B., Prehn, Jochen H. M.
Publicado 2020

BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers

por Buckley, Niamh E., Nic An tSaoir, Caoimhe B., Blayney, Jaine K., Oram, Lisa C., Crawford, Nyree T., D’Costa, Zenobia C., Quinn, Jennifer E., Kennedy, Richard D., Harkin, D. Paul, Mullan, Paul B.
Publicado 2013

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

por McCann, Christopher, Crawford, Nyree, Majkut, Joanna, Holohan, Caitriona, Armstrong, Chris W. D., Maxwell, Pamela J., Ong, Chee Wee, LaBonte, Melissa J., McDade, Simon S., Waugh, David J., Longley, Daniel B.
Publicado 2018

A revised model of TRAIL‐R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

por Humphreys, Luke M, Fox, Jennifer P, Higgins, Catherine A, Majkut, Joanna, Sessler, Tamas, McLaughlin, Kirsty, McCann, Christopher, Roberts, Jamie Z, Crawford, Nyree T, McDade, Simon S, Scott, Christopher J, Harrison, Timothy, Longley, Daniel B
Publicado 2020

The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

por Roberts, Jamie Z., Holohan, Caitriona, Sessler, Tamas, Fox, Jennifer, Crawford, Nyree, Riley, Joel S., Khawaja, Hajrah, Majkut, Joanna, Evergren, Emma, Humphreys, Luke M., Ferris, Jennifer, Higgins, Catherine, Espona-Fiedler, Margarita, Moynagh, Paul, McDade, Simon S., Longley, Daniel B.
Publicado 2020

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

por Armstrong, Chris W.D., Maxwell, Pamela J., Ong, Chee Wee, Redmond, Kelly M., McCann, Christopher, Neisen, Jessica, Ward, George A., Chessari, Gianni, Johnson, Christopher, Crawford, Nyree T., LaBonte, Melissa J., Prise, Kevin M., Robson, Tracy, Salto-Tellez, Manuel, Longley, Daniel B., Waugh, David J.J.
Publicado 2016

Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer

por Crawford, Nyree, Stott, Katie J., Sessler, Tamas, McCann, Christopher, McDaid, William, Lees, Andrea, Latimer, Cheryl, Fox, Jennifer P., Munck, Joanne M., Smyth, Tomoko, Shah, Alpesh, Martins, Vanessa, Lawler, Mark, Dunne, Philip D., Kerr, Emma M., McDade, Simon S., Coyle, Vicky M., Longley, Daniel B.
Publicado 2021

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

por Woznicki, Jerzy A., Saini, Nisha, Flood, Peter, Rajaram, Subhasree, Lee, Ciaran M., Stamou, Panagiota, Skowyra, Agnieszka, Bustamante-Garrido, Milan, Regazzoni, Karine, Crawford, Nyree, McDade, Simon S., Longley, Daniel B., Aza-Blanc, Pedro, Shanahan, Fergus, Zulquernain, Syed A., McCarthy, Jane, Melgar, Silvia, McRae, Bradford L., Nally, Ken
Publicado 2021

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

por D'Costa, Zenobia C., Higgins, Catherine, Ong, Chee Wee, Irwin, Gareth W., Boyle, David, McArt, Darragh G., McCloskey, Karen, Buckley, Niamh E., Crawford, Nyree T., Thiagarajan, Lalitha, Murray, James T., Kennedy, Richard D., Mulligan, Karl A., Harkin, D. Paul, Waugh, David J.J., Scott, Chris J., Salto-Tellez, Manuel, Williams, Richard, Mullan, Paul B.
Publicado 2014

Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists

por Grinkevitch, Vera, Wappett, Mark, Crawford, Nyree, Price, Stacey, Lees, Andrea, McCann, Christopher, McAllister, Katherine, Prehn, Jochen, Young, Jamie, Bateson, Jess, Gallagher, Lewis, Michaut, Magali, Iyer, Vivek, Chatzipli, Aikaterini, Barthorpe, Syd, Ciznadija, Daniel, Sloma, Ido, Wesa, Amy, Tice, David A., Wessels, Lodewyk, Garnett, Mathew, Longley, Daniel B., McDermott, Ultan, McDade, Simon S.
Publicado 2022