Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer

por He, Zongsheng, Khatib, Abdel-Majid, Creemers, John W. M.
Publicado 2020

Hyperphagia and Obesity in Prader–Willi Syndrome: PCSK1 Deficiency and Beyond?

por Ramos-Molina, Bruno, Molina-Vega, María, Fernández-García, José C., Creemers, John W.
Publicado 2018

Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice

por Coppola, Ilaria, Brouwers, Bas, Meulemans, Sandra, Ramos-Molina, Bruno, Creemers, John W. M.
Publicado 2021

Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer

por Declercq, Jeroen, Jacobs, Bart, Biesmans, Bart, Roth, Arnaud, Klingbiel, Dirk, Tejpar, Sabine, Creemers, John W.
Publicado 2015

In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23

por Al Rifai, Omar, Susan-Resiga, Delia, Essalmani, Rachid, Creemers, John W. M., Seidah, Nabil G., Ferron, Mathieu
Publicado 2021

Epigenetic modulations of immune cells: from normal development to tumor progression

por Xu, Yuanchun, He, Zongsheng, Du, Jing, Chen, Ziqiang, Creemers, John W. M., Wang, Bin, Li, Fan, Wang, Yaling
Publicado 2023

The Dwarf Phenotype in GH240B Mice, Haploinsufficient for the Autism Candidate Gene Neurobeachin, Is Caused by Ectopic Expression of Recombinant Human Growth Hormone

por Nuytens, Kim, Tuand, Krizia, Fu, Quili, Stijnen, Pieter, Pruniau, Vincent, Meulemans, Sandra, Vankelecom, Hugo, Creemers, John W. M.
Publicado 2014

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers

por Dahms, Sven O., Creemers, John W. M., Schaub, Yvonne, Bourenkov, Gleb P., Zögg, Thomas, Brandstetter, Hans, Than, Manuel E.
Publicado 2016

Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea

por Aerts, Laetitia, Terry, Nathalie A., Sainath, Nina N., Torres, Clarivet, Martín, Martín G., Ramos-Molina, Bruno, Creemers, John W.
Publicado 2021

Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

por Coppola, Ilaria, Brouwers, Bas, Walker, Leanne, Alar, Ceyhun, Meulemans, Sandra, White, Anne, Ramos-Molina, Bruno, Creemers, John W.M.
Publicado 2022

Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism

por Löffler, Dennis, Behrendt, Susanne, Creemers, John W.M., Klammt, Jürgen, Aust, Gabriela, Stanik, Juraj, Kiess, Wieland, Kovacs, Peter, Körner, Antje
Publicado 2016

Prodomain of Furin Promotes Phospholipid Transfer Protein Proteasomal Degradation in Hepatocytes

por Yu, Yang, Lei, Xia, Jiang, Hui, Li, Zhiqiang, Creemers, John W. M., Zhang, Ming, Qin, Shucun, Jin, Weijun, Jiang, Xian‐Cheng
Publicado 2018

The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

por Liang, Zhanfeng, Zhang, Zhaoqi, Zhang, Qian, Dong, Xue, Yang, Xiaofeng, Zhang, Jiayu, Lei, Tong, Creemers, John W.M., Zhang, Baojun, Zhao, Yong
Publicado 2022

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

por Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, Tuand, Krizia, Meulemans, Sandra, Prat, Annik, Seidah, Nabil G., Khatib, Abdel-Majid, Creemers, John W. M.
Publicado 2015

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

por Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, de Faudeur, Geoffroy, Tuand, Krizia, Meulemans, Sandra, Serneels, Lutgarde, Schraenen, Anica, Schuit, Frans, Creemers, John W. M.
Publicado 2015

Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors

por Descarpentrie, Jean, Araúzo-Bravo, Marcos J., He, Zongsheng, François, Alexia, González, Álvaro, Garcia-Gallastegi, Patricia, Badiola, Iker, Evrard, Serge, Pernot, Simon, Creemers, John W. M., Khatib, Abdel-Majid
Publicado 2022

Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation

por Courbon, Guillaume, Thomas, Jane Joy, Martinez-Calle, Marta, Wang, Xueyan, Spindler, Jadeah, Von Drasek, John, Hunt-Tobey, Bridget, Mehta, Rupal, Isakova, Tamara, Chang, Wenhan, Creemers, John W. M., Ji, Peng, Martin, Aline, David, Valentin
Publicado 2023

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

por Creemers, John W.M., Choquet, Hélène, Stijnen, Pieter, Vatin, Vincent, Pigeyre, Marie, Beckers, Sigri, Meulemans, Sandra, Than, Manuel E., Yengo, Loïc, Tauber, Maithé, Balkau, Beverley, Elliott, Paul, Jarvelin, Marjo-Riitta, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Pattou, François, Froguel, Philippe, Meyre, David
Publicado 2012

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

por Rosier, Karen, McDevitt, Molly T., Smet, Joél, Floyd, Brendan J., Verschoore, Maxime, Marcaida, Maria J., Bingman, Craig A., Lemmens, Irma, Dal Peraro, Matteo, Tavernier, Jan, Cravatt, Benjamin F., Gounko, Natalia V., Vints, Katlijn, Monnens, Yenthe, Bhalla, Kritika, Aerts, Laetitia, Rashan, Edrees H., Vanlander, Arnaud V., Van Coster, Rudy, Régal, Luc, Pagliarini, David J., Creemers, John W.M.
Publicado 2021