Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2

por Laleu, Benoît, Rubiano, Kelly, Yeo, Tomas, Hallyburton, Irene, Anderson, Mark, Crespo‐Fernandez, Benigno, Gamo, Francisco‐Javier, Antonova‐Koch, Yevgeniya, Orjuela‐Sanchez, Pamela, Wittlin, Sergio, Jana, Gouranga P., Maity, Bikash C., Chenu, Elodie, Duffy, James, Sjö, Peter, Waterson, David, Winzeler, Elizabeth, Guantai, Eric, Fidock, David A., Hansson, Thomas G.
Publicado 2022

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

por Xie, Stanley C., Metcalfe, Riley D., Mizutani, Hirotake, Puhalovich, Tanya, Hanssen, Eric, Morton, Craig J., Du, Yawei, Dogovski, Con, Huang, Shih-Chung, Ciavarri, Jeffrey, Hales, Paul, Griffin, Robert J., Cohen, Lawrence H., Chuang, Bei-Ching, Wittlin, Sergio, Deni, Ioanna, Yeo, Tomas, Ward, Kurt E., Barry, Daniel C., Liu, Boyin, Gillett, David L., Crespo-Fernandez, Benigno F., Ottilie, Sabine, Mittal, Nimisha, Churchyard, Alisje, Ferguson, Daniel, Aguiar, Anna Caroline C., Guido, Rafael V. C., Baum, Jake, Hanson, Kirsten K., Winzeler, Elizabeth A., Gamo, Francisco-Javier, Fidock, David A., Baud, Delphine, Parker, Michael W., Brand, Stephen, Dick, Lawrence R., Griffin, Michael D. W., Gould, Alexandra E., Tilley, Leann
Publicado 2021

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncompl...

por Taft, Benjamin R., Yokokawa, Fumiaki, Kirrane, Tom, Mata, Anne-Catherine, Huang, Richard, Blaquiere, Nicole, Waldron, Grace, Zou, Bin, Simon, Oliver, Vankadara, Subramanyam, Chan, Wai Ling, Ding, Mei, Sim, Sandra, Straimer, Judith, Guiguemde, Armand, Lakshminarayana, Suresh B., Jain, Jay Prakash, Bodenreider, Christophe, Thompson, Christopher, Lanshoeft, Christian, Shu, Wei, Fang, Eric, Qumber, Jafri, Chan, Katherine, Pei, Luying, Chen, Yen-Liang, Schulz, Hanna, Lim, Jessie, Abas, Siti Nurdiana, Ang, Xiaoman, Liu, Yugang, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Gamo, Francisco Javier, Crespo-Fernandez, Benigno, Rosenthal, Philip J., Cooper, Roland A., Tumwebaze, Patrick, Aguiar, Anna Caroline Campos, Campo, Brice, Campbell, Simon, Wagner, Jürgen, Diagana, Thierry T., Sarko, Christopher
Publicado 2022

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

por Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa
Publicado 2022