The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target

por Cromm, Philipp M., Crews, Craig M.
Publicado 2017

Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs

por Alabi, Shanique B., Crews, Craig M.
Publicado 2021

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

por Bond, Michael J., Crews, Craig M.
Publicado 2021

PROTAC targeted protein degraders: the past is prologue

por Békés, Miklós, Langley, David R., Crews, Craig M.
Publicado 2022

Lineage tracing of genome-edited alleles reveals high fidelity axolotl limb regeneration

por Flowers, Grant Parker, Sanor, Lucas D, Crews, Craig M
Publicado 2017

Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

por Sanor, Lucas D, Flowers, Grant Parker, Crews, Craig M
Publicado 2020

Microarray Analysis of microRNA Expression during Axolotl Limb Regeneration

por Holman, Edna C., Campbell, Leah J., Hines, John, Crews, Craig M.
Publicado 2012

Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs

por Pfaff, Patrick, Samarasinghe, Kusal T. G., Crews, Craig M., Carreira, Erick M.
Publicado 2019

Protein folding state-dependent sorting at the Golgi apparatus

por Hellerschmied, Doris, Serebrenik, Yevgeniy V., Shao, Lin, Burslem, George M., Crews, Craig M.
Publicado 2019

Targeted Degradation of Oncogenic KRAS(G12C) by VHL-Recruiting PROTACs

por Bond, Michael J., Chu, Ling, Nalawansha, Dhanusha A., Li, Ke, Crews, Craig M.
Publicado 2020

Targeted Protein Destabilization Reveals an Estrogen-mediated ER Stress Response

por Raina, Kanak, Noblin, Devin J., Serebrenik, Yevgeniy V., Adams, Alison, Zhao, Connie, Crews, Craig M.
Publicado 2014

Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response

por Serebrenik, Yevgeniy V., Hellerschmied, Doris, Toure, Momar, López-Giráldez, Francesc, Brookner, Dennis, Crews, Craig M.
Publicado 2018

OligoTRAFTACs: A generalizable method for transcription factor degradation

por Samarasinghe, Kusal T. G., An, Elvira, Genuth, Miriam A., Chu, Ling, Holley, Scott A., Crews, Craig M.
Publicado 2022

Targeted Protein Internalization and Degradation by ENDosome TArgeting Chimeras (ENDTACs)

por Nalawansha, Dhanusha A., Paiva, Stacey-Lynn, Rafizadeh, Diane N., Pettersson, Mariell, Qin, Liena, Crews, Craig M.
Publicado 2019

Retraction of “Targeted Protein Internalization and Degradation by ENDosome TArgeting Chimeras (ENDTACs)”

por Nalawansha, Dhanusha A., Paiva, Stacey-Lynn, Rafizadeh, Diane N., Pettersson, Mariell, Qin, Liena, Crews, Craig M.
Publicado 2020

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

por Smith, Blake E., Wang, Stephen L., Jaime-Figueroa, Saul, Harbin, Alicia, Wang, Jing, Hamman, Brian D., Crews, Craig M.
Publicado 2019

Mutant-selective degradation by BRAF-targeting PROTACs

por Alabi, Shanique, Jaime-Figueroa, Saul, Yao, Zhan, Gao, Yijun, Hines, John, Samarasinghe, Kusal T. G., Vogt, Lea, Rosen, Neal, Crews, Craig M.
Publicado 2021

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

por Buckley, Dennis L., Van Molle, Inge, Gareiss, Peter C., Tae, Hyun Seop, Michel, Julien, Noblin, Devin J., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Publicado 2012

Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins

por Neklesa, Taavi K., Tae, Hyun Seop, Schneekloth, Ashley R., Stulberg, Michael J., Corson, Timothy W., Sundberg, Thomas B., Raina, Kanak, Holley, Scott A., Crews, Craig M.
Publicado 2011

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

por Salami, Jemilat, Alabi, Shanique, Willard, Ryan R., Vitale, Nick J., Wang, Jing, Dong, Hanqing, Jin, Meizhong, McDonnell, Donald P., Crew, Andrew P., Neklesa, Taavi K., Crews, Craig M.
Publicado 2018