Science and Bioethics of CRISPR-Cas9 Gene Editing: An Analysis Towards Separating Facts and Fiction


por Cribbs, Adam P., Perera, Sumeth M. W.
Publicado 2017

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells

por Cribbs, Adam P, Kennedy, Alan, Gregory, Bernard, Brennan, Fionula M
Publicado 2013

TMKit: a Python interface for computational analysis of transmembrane proteins

por Sun, Jianfeng, Kulandaisamy, Arulsamy, Ru, Jinlong, Gromiha, M Michael, Cribbs, Adam P
Publicado 2023

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

por Philpott, Martin, Watson, Jonathan, Thakurta, Anjan, Brown, Tom, Brown, Tom, Oppermann, Udo, Cribbs, Adam P.
Publicado 2021

Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin

por Knowles, Helen J., Chanalaris, Anastasios, Koutsikouni, Argyro, Cribbs, Adam P., Grover, Liam M., Hulley, Philippa A.
Publicado 2023

Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs

por Larrouture, Quitterie C., Cribbs, Adam P., Rao, Srinivasa R., Philpott, Martin, Snelling, Sarah J., Knowles, Helen J.
Publicado 2021

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

por Cribbs, Adam P., Filippakopoulos, Panagis, Philpott, Martin, Wells, Graham, Penn, Henry, Oerum, Henrik, Valge-Archer, Viia, Feldmann, Marc, Oppermann, Udo
Publicado 2021

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning

por Sun, Jianfeng, Ru, Jinlong, Ramos-Mucci, Lorenzo, Qi, Fei, Chen, Zihao, Chen, Suyuan, Cribbs, Adam P., Deng, Li, Wang, Xia
Publicado 2023

Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro

por Mimpen, Jolet Y., Baldwin, Mathew J., Cribbs, Adam P., Philpott, Martin, Carr, Andrew J., Dakin, Stephanie G., Snelling, Sarah J.B.
Publicado 2021

Electrospun Scaffold Micro-Architecture Induces an Activated Transcriptional Phenotype within Tendon Fibroblasts

por Baldwin, Mathew J., Mimpen, Jolet Y., Cribbs, Adam P., Stace, Edward, Philpott, Martin, Dakin, Stephanie G., Carr, Andrew J., Snelling, Sarah JB.
Publicado 2022

An ontogenetic switch drives the positive and negative selection of B cells

por Xu, Xijin, Deobagkar-Lele, Mukta, Bull, Katherine R., Crockford, Tanya L., Mead, Adam J., Cribbs, Adam P., Sims, David, Anzilotti, Consuelo, Cornall, Richard J.
Publicado 2020

Syncytiotrophoblast Extracellular Vesicles From Late-Onset Preeclampsia Placentae Suppress Pro-Inflammatory Immune Response in THP-1 Macrophages

por Awoyemi, Toluwalase, Motta-Mejia, Carolina, Zhang, Wei, Kouser, Lubna, White, Kirsten, Kandzija, Neva, Alhamlan, Fatimah S., Cribbs, Adam P., Tannetta, Dionne, Mazey, Emily, Redman, Christopher, Kishore, Uday, Vatish, Manu
Publicado 2021

Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

por Seyhan, Attila A., Gregory, Bernard, Cribbs, Adam P., Bhalara, Sundeept, Li, Yizheng, Loreth, Christine, Zhang, Ying, Guo, Yongjing, Lin, Lih-Ling, Feldmann, Marc, Williams, Lynn M., Brennan, Fionula M., Taylor, Peter C.
Publicado 2020

Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study

por Guo, Manman, Bafligil, Cemsel, Tapmeier, Thomas, Hubbard, Carol, Manek, Sanjiv, Shang, Catherine, Martinez, Fernando O., Schmidt, Nicole, Obendorf, Maik, Hess-Stumpp, Holger, Zollner, Thomas M., Kennedy, Stephen, Becker, Christian M., Zondervan, Krina T., Cribbs, Adam P., Oppermann, Udo
Publicado 2020

Uptake of long-chain fatty acids from the bone marrow suppresses CD8(+) T-cell metabolism and function in multiple myeloma

por Gudgeon, Nancy, Giles, Hannah, Bishop, Emma L., Fulton-Ward, Taylor, Escribano-Gonzalez, Cristina, Munford, Haydn, James-Bott, Anna, Foster, Kane, Karim, Farheen, Jayawardana, Dedunu, Mahmood, Ansar, Cribbs, Adam P., Tennant, Daniel A., Basu, Supratik, Pratt, Guy, Dimeloe, Sarah
Publicado 2023

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

por Cribbs, Adam P., Terlecki-Zaniewicz, Stefan, Philpott, Martin, Baardman, Jeroen, Ahern, David, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Sampey, Brante, Mander, Palwinder K., Penn, Henry, Wordsworth, Paul, Bowness, Paul, de Winther, Menno, Prinjha, Rab K., Feldmann, Marc, Oppermann, Udo
Publicado 2020

BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming

por Sevinç, Kenan, Sevinç, Gülben Gürhan, Cavga, Ayşe Derya, Philpott, Martin, Kelekçi, Simge, Can, Hazal, Cribbs, Adam P., Yıldız, Abdullah Burak, Yılmaz, Alperen, Ayar, Enes Sefa, Arabacı, Dilşad H., Dunford, James E., Ata, Deniz, Sigua, Logan H., Qi, Jun, Oppermann, Udo, Onder, Tamer T.
Publicado 2022

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

por Yedier-Bayram, Ozlem, Gokbayrak, Bengul, Kayabolen, Alisan, Aksu, Ali Cenk, Cavga, Ayse Derya, Cingöz, Ahmet, Kala, Ezgi Yagmur, Karabiyik, Goktug, Günsay, Rauf, Esin, Beril, Morova, Tunc, Uyulur, Fırat, Syed, Hamzah, Philpott, Martin, Cribbs, Adam P., Kung, Sonia H. Y., Lack, Nathan A., Onder, Tamer T., Bagci-Onder, Tugba
Publicado 2022

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

por Ozyerli-Goknar, Ezgi, Kala, Ezgi Yagmur, Aksu, Ali Cenk, Bulut, Ipek, Cingöz, Ahmet, Nizamuddin, Sheikh, Biniossek, Martin, Seker-Polat, Fidan, Morova, Tunc, Aztekin, Can, Kung, Sonia H. Y., Syed, Hamzah, Tuncbag, Nurcan, Gönen, Mehmet, Philpott, Martin, Cribbs, Adam P., Acilan, Ceyda, Lack, Nathan A., Onder, Tamer T., Timmers, H. T. Marc, Bagci-Onder, Tugba
Publicado 2023

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

por Vazquez‐Rodriguez, Saleta, Wright, Miranda, Rogers, Catherine M., Cribbs, Adam P., Velupillai, Srikannathasan, Philpott, Martin, Lee, Henry, Dunford, James E., Huber, Kilian V. M., Robers, Matthew B., Vasta, James D., Thezenas, Marie‐Laetitia, Bonham, Sarah, Kessler, Benedikt, Bennett, James, Fedorov, Oleg, Raynaud, Florence, Donovan, Adam, Blagg, Julian, Bavetsias, Vassilios, Oppermann, Udo, Bountra, Chas, Kawamura, Akane, Brennan, Paul E.
Publicado 2018