Prediction of the Neurotoxic Potential of Chemicals Based on Modelling of Molecular Initiating Events Upstream of the Adverse Outcome Pathways of (Developmental) Neurotoxicity

por Gadaleta, Domenico, Spînu, Nicoleta, Roncaglioni, Alessandra, Cronin, Mark T. D., Benfenati, Emilio
Publicado 2022

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

por Marchese Robinson, Richard L, Cronin, Mark T D, Richarz, Andrea-Nicole, Rallo, Robert
Publicado 2015

Unlocking the potential of in silico chemical safety assessment – A report on a cross-sector symposium on current opportunities and future challenges

por Cronin, Mark T.D., Madden, Judith C., Yang, Chihae, Worth, Andrew P.
Publicado 2019

A matter of trust: Learning lessons about causality will make qAOPs credible

por Spînu, Nicoleta, Cronin, Mark T.D., Madden, Judith C., Worth, Andrew P.
Publicado 2022

Guidance for good practice in the application of machine learning in development of toxicological quantitative structure-activity relationships (QSARs)

por Belfield, Samuel J., Cronin, Mark T.D., Enoch, Steven J., Firman, James W.
Publicado 2023

In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR

por Pawar, Gopal, Madden, Judith C., Ebbrell, David, Firman, James W., Cronin, Mark T. D.
Publicado 2019

Quantitative adverse outcome pathway (qAOP) models for toxicity prediction

por Spinu, Nicoleta, Cronin, Mark T. D., Enoch, Steven J., Madden, Judith C., Worth, Andrew P.
Publicado 2020

The use of Bayesian methodology in the development and validation of a tiered assessment approach towards prediction of rat acute oral toxicity

por Firman, James W., Cronin, Mark T. D., Rowe, Philip H., Semenova, Elizaveta, Doe, John E.
Publicado 2022

Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs.

por Eriksson, Lennart, Jaworska, Joanna, Worth, Andrew P, Cronin, Mark T D, McDowell, Robert M, Gramatica, Paola
Publicado 2003

Molecular Modelling Study of the PPARγ Receptor in Relation to the Mode of Action/Adverse Outcome Pathway Framework for Liver Steatosis

por Tsakovska, Ivanka, Al Sharif, Merilin, Alov, Petko, Diukendjieva, Antonia, Fioravanzo, Elena, Cronin, Mark T. D., Pajeva, Ilza
Publicado 2014

Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances.

por Cronin, Mark T D, Walker, John D, Jaworska, Joanna S, Comber, Michael H I, Watts, Christopher D, Worth, Andrew P
Publicado 2003

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.

por Cronin, Mark T D, Jaworska, Joanna S, Walker, John D, Comber, Michael H I, Watts, Christopher D, Worth, Andrew P
Publicado 2003

Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens

por Batke, Monika, Afrapoli, Fatemeh Moradi, Kellner, Rupert, Rathman, James F., Yang, Chihae, Cronin, Mark T. D., Escher, Sylvia E.
Publicado 2021

In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects

por Cronin, Mark T.D., Enoch, Steven J., Mellor, Claire L., Przybylak, Katarzyna R., Richarz, Andrea-Nicole, Madden, Judith C.
Publicado 2017

Automated workflows for modelling chemical fate, kinetics and toxicity

por Sala Benito, J.V., Paini, Alicia, Richarz, Andrea-Nicole, Meinl, Thorsten, Berthold, Michael R., Cronin, Mark T.D., Worth, Andrew P.
Publicado 2017

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

por Burden, Natalie, Sewell, Fiona, Andersen, Melvin E, Boobis, Alan, Chipman, J Kevin, Cronin, Mark T D, Hutchinson, Thomas H, Kimber, Ian, Whelan, Maurice
Publicado 2015

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

por Botham, Philip, Cronin, Mark T. D., Currie, Richard, Doe, John, Funk-Weyer, Dorothee, Gant, Timothy W., Leist, Marcel, Marty, Sue, van Ravenzwaay, Bennard, Westmoreland, Carl
Publicado 2023

A framework for chemical safety assessment incorporating new approach methodologies within REACH

por Ball, Nicholas, Bars, Remi, Botham, Philip A., Cuciureanu, Andreea, Cronin, Mark T. D., Doe, John E., Dudzina, Tatsiana, Gant, Timothy W., Leist, Marcel, van Ravenzwaay, Bennard
Publicado 2022

Construction of an In Silico Structural Profiling Tool Facilitating Mechanistically Grounded Classification of Aquatic Toxicants

por Firman, James W., Ebbrell, David J., Bauer, Franklin J., Sapounidou, Maria, Hodges, Geoff, Campos, Bruno, Roberts, Jayne, Gutsell, Steve, Thomas, Paul C., Bonnell, Mark, Cronin, Mark T. D.
Publicado 2022

G × E interactions as a basis for toxicological uncertainty

por Suciu, Ilinca, Pamies, David, Peruzzo, Roberta, Wirtz, Petra H., Smirnova, Lena, Pallocca, Giorgia, Hauck, Christof, Cronin, Mark T. D., Hengstler, Jan G., Brunner, Thomas, Hartung, Thomas, Amelio, Ivano, Leist, Marcel
Publicado 2023