F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE

por Peschke, Madeleine, Brieke, Clara, Cryle, Max J.
Publicado 2016

Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934

por Ulrich, Veronika, Brieke, Clara, Cryle, Max J
Publicado 2016

New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis

por Kittilä, Tiia, Mollo, Aurelio, Charkoudian, Louise K., Cryle, Max J.
Publicado 2016

Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase

por Kaniusaite, Milda, Goode, Robert J. A., Tailhades, Julien, Schittenhelm, Ralf B., Cryle, Max J.
Publicado 2020

The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

por Kaniusaite, Milda, Goode, Robert J. A., Schittenhelm, Ralf B., Makris, Thomas M., Cryle, Max J.
Publicado 2019

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

por Schoppet, Melanie, Peschke, Madeleine, Kirchberg, Anja, Wiebach, Vincent, Süssmuth, Roderich D., Stegmann, Evi, Cryle, Max J.
Publicado 2018

A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics

por Kaniusaite, Milda, Tailhades, Julien, Marschall, Edward A., Goode, Robert J. A., Schittenhelm, Ralf B., Cryle, Max J.
Publicado 2019

Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides

por Hansen, Mathias H., Adamek, Martina, Iftime, Dumitrita, Petras, Daniel, Schuseil, Frauke, Grond, Stephanie, Stegmann, Evi, Cryle, Max J., Ziemert, Nadine
Publicado 2023

Staphylococcus aureus entanglement in self-assembling β-peptide nanofibres decorated with vancomycin

por Payne, Jennifer A. E., Kulkarni, Ketav, Izore, Thierry, Fulcher, Alex J., Peleg, Anton Y., Aguilar, Marie-Isabel, Cryle, Max J., Del Borgo, Mark P.
Publicado 2021

The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

por Greule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R., Cryle, Max J.
Publicado 2022

Cytochrome P450(Blt) Enables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks

por Zhao, Yongwei, Marschall, Edward, Treisman, Maxine, McKay, Alasdair, Padva, Leo, Crüsemann, Max, Nelson, David R., Steer, David L., Schittenhelm, Ralf B., Tailhades, Julien, Cryle, Max J.
Publicado 2022

Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

por Kittilä, Tiia, Kittel, Claudia, Tailhades, Julien, Butz, Diane, Schoppet, Melanie, Büttner, Anita, Goode, Rob J. A., Schittenhelm, Ralf B., van Pee, Karl-Heinz, Süssmuth, Roderich D., Wohlleben, Wolfgang, Cryle, Max J., Stegmann, Evi
Publicado 2017

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

por Izoré, Thierry, Candace Ho, Y. T., Kaczmarski, Joe A., Gavriilidou, Athina, Chow, Ka Ho, Steer, David L., Goode, Robert J. A., Schittenhelm, Ralf B., Tailhades, Julien, Tosin, Manuela, Challis, Gregory L., Krenske, Elizabeth H., Ziemert, Nadine, Jackson, Colin J., Cryle, Max J.
Publicado 2021

Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus

por Payne, Jennifer A. E., Tailhades, Julien, Ellett, Felix, Kostoulias, Xenia, Fulcher, Alex J., Fu, Ting, Leung, Ryan, Louch, Stephanie, Tran, Amy, Weber, Severin A., Schittenhelm, Ralf B., Lieschke, Graham J., Qin, Chengxue Helena, Irima, Daniel, Peleg, Anton Y., Cryle, Max J.
Publicado 2021

P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate

por Zhang, Songya, Zhang, Lin, Greule, Anja, Tailhades, Julien, Marschall, Edward, Prasongpholchai, Panward, Leng, Daniel J., Zhang, Jingfan, Zhu, Jing, Kaczmarski, Joe A., Schittenhelm, Ralf B., Einsle, Oliver, Jackson, Colin J., Alberti, Fabrizio, Bechthold, Andreas, Zhang, Youming, Tosin, Manuela, Si, Tong, Cryle, Max J.
Publicado 2023

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

por Greule, Anja, Izoré, Thierry, Iftime, Dumitrita, Tailhades, Julien, Schoppet, Melanie, Zhao, Yongwei, Peschke, Madeleine, Ahmed, Iftekhar, Kulik, Andreas, Adamek, Martina, Goode, Robert J. A., Schittenhelm, Ralf B., Kaczmarski, Joe A., Jackson, Colin J., Ziemert, Nadine, Krenske, Elizabeth H., De Voss, James J., Stegmann, Evi, Cryle, Max J.
Publicado 2019

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F(420)-0 in Mycobacteria

por Grinter, Rhys, Ney, Blair, Brammananth, Rajini, Barlow, Christopher K., Cordero, Paul R. F., Gillett, David L., Izoré, Thierry, Cryle, Max J., Harold, Liam K., Cook, Gregory M., Taiaroa, George, Williamson, Deborah A., Warden, Andrew C., Oakeshott, John G., Taylor, Matthew C., Crellin, Paul K., Jackson, Colin J., Schittenhelm, Ralf B., Coppel, Ross L., Greening, Chris
Publicado 2020

Uncovering protein–protein interactions through a team-based undergraduate biochemistry course

por Cookmeyer, David L., Winesett, Emily S., Kokona, Bashkim, Huff, Adam R., Aliev, Sabina, Bloch, Noah B., Bulos, Joshua A., Evans, Irene L., Fagre, Christian R., Godbe, Kerilyn N., Khromava, Maryna, Konstantinovsky, Daniel M., Lafrance, Alexander E., Lamacki, Alexandra J., Parry, Robert C., Quinn, Jeanne M., Thurston, Alana M., Tsai, Kathleen J. S., Mollo, Aurelio, Cryle, Max J., Fairman, Robert, Charkoudian, Louise K.
Publicado 2017