The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α(1)-adrenergic receptors

por Meijles, Daniel N., Fuller, Stephen J., Cull, Joshua J., Alharbi, Hajed O., Cooper, Susanna T.E., Sugden, Peter H., Clerk, Angela
Publicado 2021

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

por Fuller, Stephen J., Edmunds, Nick S., McGuffin, Liam J., Hardyman, Michelle A., Cull, Joshua J., Alharbi, Hajed O., Meijles, Daniel N., Sugden, Peter H., Clerk, Angela
Publicado 2021

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

por Alharbi, Hajed O., Hardyman, Michelle A., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Glennon, Peter E., Fuller, Stephen J., Sugden, Peter H., Clerk, Angela
Publicado 2022

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

por Meijles, Daniel N., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Haines, Zoe H.R., Fuller, Stephen J., O’Gara, Peter, Sheppard, Mary N., Harding, Sian E., Sugden, Peter H., Clerk, Angela
Publicado 2020

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

por Meijles, Daniel N., Cull, Joshua J., Cooper, Susanna T.E., Markou, Thomais, Hardyman, Michelle A., Fuller, Stephen J., Alharbi, Hajed O., Haines, Zoe H.R., Alcantara-Alonso, Viridiana, Glennon, Peter E., Sheppard, Mary N., Sugden, Peter H., Clerk, Angela
Publicado 2021

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

por Marshall, Jacqueline J.T., Cull, Joshua J., Alharbi, Hajed O., Zaw Thin, May, Cooper, Susanna T.E., Barrington, Christopher, Vanyai, Hannah, Snoeks, Thomas, Siow, Bernard, Suáarez-Bonnet, Alejandro, Herbert, Eleanor, Stuckey, Daniel J., Cameron, Angus J.M., Prin, Fabrice, Cook, Andrew C., Priestnall, Simon L., Chotani, Sonia, Rackham, Owen J. L., Meijles, Daniel N., Mohun, Tim, Clerk, Angela, Parker, Peter J.
Publicado 2022

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

por Clerk, Angela, Meijles, Daniel N., Hardyman, Michelle A., Fuller, Stephen J., Chothani, Sonia P., Cull, Joshua J., Cooper, Susanna T.E., Alharbi, Hajed O., Vanezis, Konstantinos, Felkin, Leanne E., Markou, Thomais, Leonard, Samuel J., Shaw, Spencer W., Rackham, Owen J.L., Cook, Stuart A., Glennon, Peter E., Sheppard, Mary N., Sembrat, John C., Rojas, Mauricio, McTiernan, Charles F., Barton, Paul J., Sugden, Peter H.
Publicado 2022