ODP353 Sustained Suppression of IGF1 with AZP-3813, a Bicyclic 16-Amino Acid Peptide Antagonist of the Human Growth Hormone Receptor and a Potential New Treatment for Acromegaly

por Culler, Michael, Milano, Stephane, Kurasaki, Haruaki, Tomiyama, Tatsuya, Reid, Patrick, van der Lely, Aart Jan, Culler, Michael
Publicado 2022

OR21-6 AZP-3601, a Long-Acting Parathyroid Hormone (PTH) Analog, Normalizes Blood Calcium in Thyroparathyroidectomized (TPTX) Rats Without Causing Deleterious Changes in Bone

por Culler, Michael, Gardella, Thomas, Aksu, Cagri
Publicado 2022

OR06-02 TBR-760, a Chimeric Somatostatin-Dopamine Compound, Arrests Aggressive Non-Functioning Pituitary Adenoma Growth In Vivo

por Halem, Heather A, Hochgeschwender, Ute, Thiagalingam, Arunthi, Culler, Michael D
Publicado 2020

Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity

por Hassouna, Rim, Labarthe, Alexandra, Zizzari, Philippe, Videau, Catherine, Culler, Michael, Epelbaum, Jacques, Tolle, Virginie
Publicado 2013

OR05-5 AZP-3404, a 9-Amino Acid Peptide Analog of Insulin-Like Growth Factor-Binding Protein 2, Reverses Insulin Resistance in Leptin-Deficient ob/ob Mice

por Milano, Stephane, Delale, Thomas, Abribat, Thierry, Culler, Michael, van der Lely, Aart, Clemmons, David
Publicado 2019

A Single Administration of AZP-3601, a Novel, Long-Acting PTH Analog, Induces a Significant and Sustained Calcemic Response: Preliminary Data From a Randomized, Double-Blind, Place...

por Allas, Soraya, Ovize, Michel, Culler, Michael D, Geraul, Clarisse, van de Wetering, Jeroen, Mannstadt, Michael
Publicado 2021

Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas

por Kim, Jean, Oh, Ju Hun, Harlem, Heather, Culler, Michael D., Ku, Cheol Ryong, Lee, Eun Jig
Publicado 2020

THU046 Repeated Treatment With AZP-3813, A Bicyclic, 16-Amino Acid Peptide Antagonist Of The Human Growth Hormone Receptor, Induces Enhanced Suppression Of IGF1 In Beagle Dogs

por Ravel, Guillaume, Chalmey, Clémentine, Berardet, Corentin, Duracher, David, Kurasaki, Haruaki, Tomiyama, Tatsuya, Reid, Patrick, Culler, Michael D
Publicado 2023

AZP-3404, a Peptide Analog of IGFBP-2, Induces Weight Loss and Improves Glucose Metabolism in Leptin-Resistant db/db Mice

por Culler, Michael D, Milano, Stéphane, Delale, Thomas, Ovize, Michel, van der Lelij, Aart Jan, Clemmons, David R
Publicado 2021

TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice

por Halem, Heather A, Hochgeschwender, Ute, Rih, Jeong Keun, Nelson, Richard, Johnson, G Allan, Thiagalingam, Arunthi, Culler, Michael D
Publicado 2020

Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

por Su, Xiangdong, Vicker, Nigel, Thomas, Mark P, Pradaux-Caggiano, Fabienne, Halem, Heather, Culler, Michael D, Potter, Barry V L
Publicado 2011

Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1

por Su, Xiangdong, Pradaux-Caggiano, Fabienne, Vicker, Nigel, Thomas, Mark P, Halem, Heather, Culler, Michael D, Potter, Barry V L
Publicado 2011

Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors

por Su, Xiangdong, Halem, Heather A., Thomas, Mark P., Moutrille, Cecile, Culler, Michael D., Vicker, Nigel, Potter, Barry V.L.
Publicado 2012

Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model

por Lenk, Karsten, Palus, Sandra, Schur, Robert, Datta, Rakesh, Dong, Jesse, Culler, Michael D., Anker, Stefan, Springer, Jochen, Schuler, Gerhard, Adams, Volker
Publicado 2012

Clinical Burden and Practice Patterns in Patients With Chronic Hypoparathyroidism in the United States (US): A Claims Data Analysis Using Surgery-Based Criteria

por Sharma, Dolly, Deering, Kathleen L, Loustau, Patrick, Culler, Michael D, Allas, Soraya, Weiss, Blandine, Mitchell, Deborah M, Astolfi, Danette, Mannstadt, Michael
Publicado 2021

Somatostatin Analogue Treatment Primarily Induce miRNA Expression Changes and Up-Regulates Growth Inhibitory miR-7 and miR-148a in Neuroendocrine Cells

por Døssing, Kristina B. V., Kjær, Christina, Vikeså, Jonas, Binderup, Tina, Knigge, Ulrich, Culler, Michael D., Kjær, Andreas, Federspiel, Birgitte, Friis-Hansen, Lennart
Publicado 2018

Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

por Palus, Sandra, Schur, Robert, Akashi, Yoshihiro J., Bockmeyer, Barbara, Datta, Rakesh, Halem, Heather, Dong, Jesse, Culler, Michael D., Adams, Volker, Anker, Stefan D., Springer, Jochen
Publicado 2011

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

por Kievit, Paul, Halem, Heather, Marks, Daniel L., Dong, Jesse Z., Glavas, Maria M., Sinnayah, Puspha, Pranger, Lindsay, Cowley, Michael A., Grove, Kevin L., Culler, Michael D.
Publicado 2013

International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature

por Günther, Thomas, Tulipano, Giovanni, Dournaud, Pascal, Bousquet, Corinne, Csaba, Zsolt, Kreienkamp, Hans-Jürgen, Lupp, Amelie, Korbonits, Márta, Castaño, Justo P., Wester, Hans-Jürgen, Culler, Michael, Melmed, Shlomo, Schulz, Stefan
Publicado 2018

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular pa...

por Luque, Raul M., Sampedro-Nuñez, Miguel, Gahete, Manuel D., Ramos-Levi, Ana, Ibáñez-Costa, Alejandro, Rivero-Cortés, Esther, Serrano-Somavilla, Ana, Adrados, Magdalena, Culler, Michael D., Castaño, Justo P., Marazuela, Mónica
Publicado 2015