OR06-02 TBR-760, a Chimeric Somatostatin-Dopamine Compound, Arrests Aggressive Non-Functioning Pituitary Adenoma Growth In Vivo

por Halem, Heather A, Hochgeschwender, Ute, Thiagalingam, Arunthi, Culler, Michael D
Publicado 2020

A Single Administration of AZP-3601, a Novel, Long-Acting PTH Analog, Induces a Significant and Sustained Calcemic Response: Preliminary Data From a Randomized, Double-Blind, Place...

por Allas, Soraya, Ovize, Michel, Culler, Michael D, Geraul, Clarisse, van de Wetering, Jeroen, Mannstadt, Michael
Publicado 2021

Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas

por Kim, Jean, Oh, Ju Hun, Harlem, Heather, Culler, Michael D., Ku, Cheol Ryong, Lee, Eun Jig
Publicado 2020

THU046 Repeated Treatment With AZP-3813, A Bicyclic, 16-Amino Acid Peptide Antagonist Of The Human Growth Hormone Receptor, Induces Enhanced Suppression Of IGF1 In Beagle Dogs

por Ravel, Guillaume, Chalmey, Clémentine, Berardet, Corentin, Duracher, David, Kurasaki, Haruaki, Tomiyama, Tatsuya, Reid, Patrick, Culler, Michael D
Publicado 2023

AZP-3404, a Peptide Analog of IGFBP-2, Induces Weight Loss and Improves Glucose Metabolism in Leptin-Resistant db/db Mice

por Culler, Michael D, Milano, Stéphane, Delale, Thomas, Ovize, Michel, van der Lelij, Aart Jan, Clemmons, David R
Publicado 2021

TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice

por Halem, Heather A, Hochgeschwender, Ute, Rih, Jeong Keun, Nelson, Richard, Johnson, G Allan, Thiagalingam, Arunthi, Culler, Michael D
Publicado 2020

Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

por Su, Xiangdong, Vicker, Nigel, Thomas, Mark P, Pradaux-Caggiano, Fabienne, Halem, Heather, Culler, Michael D, Potter, Barry V L
Publicado 2011

Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1

por Su, Xiangdong, Pradaux-Caggiano, Fabienne, Vicker, Nigel, Thomas, Mark P, Halem, Heather, Culler, Michael D, Potter, Barry V L
Publicado 2011

Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors

por Su, Xiangdong, Halem, Heather A., Thomas, Mark P., Moutrille, Cecile, Culler, Michael D., Vicker, Nigel, Potter, Barry V.L.
Publicado 2012

Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model

por Lenk, Karsten, Palus, Sandra, Schur, Robert, Datta, Rakesh, Dong, Jesse, Culler, Michael D., Anker, Stefan, Springer, Jochen, Schuler, Gerhard, Adams, Volker
Publicado 2012

Clinical Burden and Practice Patterns in Patients With Chronic Hypoparathyroidism in the United States (US): A Claims Data Analysis Using Surgery-Based Criteria

por Sharma, Dolly, Deering, Kathleen L, Loustau, Patrick, Culler, Michael D, Allas, Soraya, Weiss, Blandine, Mitchell, Deborah M, Astolfi, Danette, Mannstadt, Michael
Publicado 2021

Somatostatin Analogue Treatment Primarily Induce miRNA Expression Changes and Up-Regulates Growth Inhibitory miR-7 and miR-148a in Neuroendocrine Cells

por Døssing, Kristina B. V., Kjær, Christina, Vikeså, Jonas, Binderup, Tina, Knigge, Ulrich, Culler, Michael D., Kjær, Andreas, Federspiel, Birgitte, Friis-Hansen, Lennart
Publicado 2018

Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

por Palus, Sandra, Schur, Robert, Akashi, Yoshihiro J., Bockmeyer, Barbara, Datta, Rakesh, Halem, Heather, Dong, Jesse, Culler, Michael D., Adams, Volker, Anker, Stefan D., Springer, Jochen
Publicado 2011

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

por Kievit, Paul, Halem, Heather, Marks, Daniel L., Dong, Jesse Z., Glavas, Maria M., Sinnayah, Puspha, Pranger, Lindsay, Cowley, Michael A., Grove, Kevin L., Culler, Michael D.
Publicado 2013

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular pa...

por Luque, Raul M., Sampedro-Nuñez, Miguel, Gahete, Manuel D., Ramos-Levi, Ana, Ibáñez-Costa, Alejandro, Rivero-Cortés, Esther, Serrano-Somavilla, Ana, Adrados, Magdalena, Culler, Michael D., Castaño, Justo P., Marazuela, Mónica
Publicado 2015

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors

por Sampedro-Núñez, Miguel, Luque, Raúl M., Ramos-Levi, Ana M., Gahete, Manuel D., Serrano-Somavilla, Ana, Villa-Osaba, Alicia, Adrados, Magdalena, Ibáñez-Costa, Alejandro, Martín-Pérez, Elena, Culler, Michael D., Marazuela, Mónica, Castaño, Justo P.
Publicado 2015

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

por Gahete, Manuel D., Rincón-Fernández, David, Durán-Prado, Mario, Hergueta-Redondo, Marta, Ibáñez-Costa, Alejandro, Rojo-Sebastián, Alejandro, Gracia-Navarro, Francisco, Culler, Michael D., Casanovas, Oriol, Moreno-Bueno, Gema, Luque, Raúl M., Castaño, Justo P.
Publicado 2016

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

por Skrapits, Katalin, Sárvári, Miklós, Farkas, Imre, Göcz, Balázs, Takács, Szabolcs, Rumpler, Éva, Váczi, Viktória, Vastagh, Csaba, Rácz, Gergely, Matolcsy, András, Solymosi, Norbert, Póliska, Szilárd, Tóth, Blanka, Erdélyi, Ferenc, Szabó, Gábor, Culler, Michael D, Allet, Cecile, Cotellessa, Ludovica, Prévot, Vincent, Giacobini, Paolo, Hrabovszky, Erik
Publicado 2021

The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer

por Puig-Domingo, Manel, Luque, Raúl M., Reverter, Jordi L., López-Sánchez, Laura M., Gahete, Manuel D., Culler, Michael D., Díaz-Soto, Gonzalo, Lomeña, Francisco, Squarcia, Mattia, Mate, José Luis, Mora, Mireia, Fernández-Cruz, Laureano, Vidal, Oscar, Alastrué, Antonio, Balibrea, Jose, Halperin, Irene, Mauricio, Dídac, Castaño, Justo P.
Publicado 2014

In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features

por Ibáñez-Costa, Alejandro, Gahete, Manuel D., Rivero-Cortés, Esther, Rincón-Fernández, David, Nelson, Richard, Beltrán, Manuel, de la Riva, Andrés, Japón, Miguel A., Venegas-Moreno, Eva, Gálvez, Ma Ángeles, García-Arnés, Juan A., Soto-Moreno, Alfonso, Morgan, Jennifer, Tsomaia, Natia, Culler, Michael D., Dieguez, Carlos, Castaño, Justo P., Luque, Raúl M.
Publicado 2015