Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2

por Culp-Hill, Rachel, Stevens, Brett M., Jones, Courtney L., Pei, Shanshan, Dzieciatkowska, Monika, Minhajuddin, Mohammad, Jordan, Craig T., D’Alessandro, Angelo
Publicado 2023

Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron

por La Carpia, Francesca, Wojczyk, Boguslaw S., Annavajhala, Medini K., Rebbaa, Abdelhadi, Culp-Hill, Rachel, D’Alessandro, Angelo, Freedberg, Daniel E., Uhlemann, Anne-Catrin, Hod, Eldad A.
Publicado 2019

Targeting Host Glycolysis as a Strategy for Antimalarial Development

por Jezewski, Andrew J., Lin, Yu-Hsi, Reisz, Julie A., Culp-Hill, Rachel, Barekatain, Yasaman, Yan, Victoria C., D’Alessandro, Angelo, Muller, Florian L., Odom John, Audrey R.
Publicado 2021

Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity

por D’Alessandro, Angelo, Fu, Xiaoyun, Kanias, Tamir, Reisz, Julie A., Culp-Hill, Rachel, Guo, Yuelong, Gladwin, Mark T., Page, Grier, Kleinman, Steve, Lanteri, Marion, Stone, Mars, Busch, Michael P., Zimring, James C.
Publicado 2020

Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice

por Ballak, Dov B., Brunt, Vienna E., Sapinsley, Zachary J., Ziemba, Brian P., Richey, James J., Zigler, Melanie C., Johnson, Lawrence C., Gioscia‐Ryan, Rachel A., Culp‐Hill, Rachel, Eisenmesser, Elan Z., D'Alessandro, Angelo, Dinarello, Charles A., Seals, Douglas R.
Publicado 2019

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

por Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.
Publicado 2019

Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity

por O’Brien, Cristiana, Ling, Tianyi, Berman, Jacob M., Culp-Hill, Rachel, Reisz, Julie A., Rondeau, Vincent, Jahangiri, Soheil, St-Germain, Jonathan, Macwan, Vinitha, Astori, Audrey, Zeng, Andy, Hong, Jun Young, Li, Meng, Yang, Min, Jana, Sadhan, Gamboni, Fabia, Tsao, Emily, Liu, Weiyi, Dick, John E., Lin, Hening, Melnick, Ari, Tikhonova, Anastasia, Arruda, Andrea, Minden, Mark D., Raught, Brian, D'Alessandro, Angelo, Jones, Courtney L.
Publicado 2023

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

por Giddings, Emily L., Champagne, Devin P., Wu, Meng-Han, Laffin, Joshua M., Thornton, Tina M., Valenca-Pereira, Felipe, Culp-Hill, Rachel, Fortner, Karen A., Romero, Natalia, East, James, Cao, Phoebe, Arias-Pulido, Hugo, Sidhu, Karatatiwant S., Silverstrim, Brian, Kam, Yoonseok, Kelley, Shana, Pereira, Mark, Bates, Susan E., Bunn, Janice Y., Fiering, Steven N., Matthews, Dwight E., Robey, Robert W., Stich, Domink, D’Alessandro, Angelo, Rincon, Mercedes
Publicado 2021