Synthesis of the Tetracyclic Framework of Polycyclic Spiro Lignan Natural Products

por Ali, Ghada, Cuny, Gregory D.
Publicado 2020

8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities

por Ali, Ghada, Cuny, Gregory D.
Publicado 2021

Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity

por Kim, Youngchang, Makowska-Grzyska, Magdalena, Gorla, Suresh Kumar, Gollapalli, Deviprasad R., Cuny, Gregory D., Joachimiak, Andrzej, Hedstrom, Lizbeth
Publicado 2015

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

por Pawlowic, Mattie C., Somepalli, Mastanbabu, Sateriale, Adam, Herbert, Gillian T., Gibson, Alexis R., Cuny, Gregory D., Hedstrom, Lizbeth, Striepen, Boris
Publicado 2019

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

por Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.
Publicado 2018

Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants

por Mohedas, Agustin H., Wang, You, Sanvitale, Caroline E., Canning, Peter, Choi, Sungwoon, Xing, Xuechao, Bullock, Alex N., Cuny, Gregory D., Yu, Paul B.
Publicado 2014

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis

por McNamara, Colleen R., Ahuja, Ruchita, Osafo-Addo, Awo D., Barrows, Douglas, Kettenbach, Arminja, Skidan, Igor, Teng, Xin, Cuny, Gregory D., Gerber, Scott, Degterev, Alexei
Publicado 2013

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

por Cherry, Jonathan J, Osman, Erkan Y, Evans, Matthew C, Choi, Sungwoon, Xing, Xuechao, Cuny, Gregory D, Glicksman, Marcie A, Lorson, Christian L, Androphy, Elliot J
Publicado 2013

Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition

por Lee, Seungheon, Love, Melissa S., Modukuri, Ramkumar, Chatterjee, Arnab K., Huerta, Lauren, Lawson, Ann P., McNamara, Case W., Mead, Jan R., Hedstrom, Lizbeth, Cuny, Gregory D.
Publicado 2023

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

por Cabrol, Christelle, Huzarska, Malwina A., Dinolfo, Christopher, Rodriguez, Maria C., Reinstatler, Lael, Ni, Jake, Yeh, Li-An, Cuny, Gregory D., Stein, Ross L., Selkoe, Dennis J., Leissring, Malcolm A.
Publicado 2009

Synthesis, in Vitro Evaluation and Cocrystal Structure of 4-Oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase (CpIMPDH) Inhibitors

por Sun, Zhuming, Khan, Jihan, Makowska-Grzyska, Magdalena, Zhang, Minjia, Cho, Joon Hyung, Suebsuwong, Chalada, Vo, Pascal, Gollapalli, Deviprasad R., Kim, Youngchang, Joachimiak, Andrzej, Hedstrom, Lizbeth, Cuny, Gregory D.
Publicado 2014

An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

por Haile, Colin N., Baker, Miah D., Sanchez, Sergio A., Lopez Arteaga, Carlos A., Duddupudi, Anantha L., Cuny, Gregory D., Norton, Elizabeth B., Kosten, Thomas R., Kosten, Therese A.
Publicado 2022

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

por Delanghe, Tom, Huyghe, Jon, Lee, Seungheon, Priem, Dario, Van Coillie, Samya, Gilbert, Barbara, Choi, Sze Men, Vandenabeele, Peter, Degterev, Alexei, Cuny, Gregory D., Dondelinger, Yves, Bertrand, Mathieu J. M.
Publicado 2021

A New Class of Small Molecule Inhibitor of BMP Signaling

por Sanvitale, Caroline E., Kerr, Georgina, Chaikuad, Apirat, Ramel, Marie-Christine, Mohedas, Agustin H., Reichert, Sabine, Wang, You, Triffitt, James T., Cuny, Gregory D., Yu, Paul B., Hill, Caroline S., Bullock, Alex N.
Publicado 2013

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

por Makowska-Grzyska, Magdalena, Kim, Youngchang, Gorla, Suresh Kumar, Wei, Yang, Mandapati, Kavitha, Zhang, Minjia, Maltseva, Natalia, Modi, Gyan, Boshoff, Helena I., Gu, Minyi, Aldrich, Courtney, Cuny, Gregory D., Hedstrom, Lizbeth, Joachimiak, Andrzej
Publicado 2015

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

por Canning, Peter, Ruan, Qui, Schwerd, Tobias, Hrdinka, Matous, Maki, Jenny L., Saleh, Danish, Suebsuwong, Chalada, Ray, Soumya, Brennan, Paul E., Cuny, Gregory D., Uhlig, Holm H., Gyrd-Hansen, Mads, Degterev, Alexei, Bullock, Alex N.
Publicado 2015

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

por Takahashi, Kou, Kong, Qiongman, Lin, Yuchen, Stouffer, Nathan, Schulte, Delanie A., Lai, Liching, Liu, Qibing, Chang, Ling-Chu, Dominguez, Sky, Xing, Xuechao, Cuny, Gregory D., Hodgetts, Kevin J., Glicksman, Marcie A., Lin, Chien-Liang Glenn
Publicado 2015

Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge

por Stone, Addison E., Scheuermann, Sarah E., Haile, Colin N., Cuny, Gregory D., Velasquez, Marcela Lopez, Linhuber, Joshua P., Duddupudi, Anantha L., Vigliaturo, Jennifer R., Pravetoni, Marco, Kosten, Therese A., Kosten, Thomas R., Norton, Elizabeth B.
Publicado 2021

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

por Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads
Publicado 2018

A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex

por Chen, Han, Lye, Ming F., Gorgulla, Christoph, Ficarro, Scott B., Cuny, Gregory D., Scott, David A., Wu, Fan, Rothlauf, Paul W., Wang, Xiaoou, Fernandez, Rosio, Pesola, Jean M., Draga, Sorin, Marto, Jarrod A., Hogle, James M., Arthanari, Haribabu, Coen, Donald M.
Publicado 2023