An impaired natriuretic peptide hormone system may play a role in COVID‐19 severity in vulnerable populations

por Currie, Mark G., Zimmer, Daniel P., Halushka, Perry V.
Publicado 2020

Linaclotide induces secretion of cGMP from mouse colonic epithelium

por Tchernychev, Boris, Jacobson, Sarah, Kurtz, Caroline, Currie, Mark, Silos-Santiago, Inmaculada
Publicado 2013

Targets of histone H3 lysine 9 methyltransferases

por Levinsky, Aidan J., McEdwards, Gregor, Sethna, Nasha, Currie, Mark A.
Publicado 2022

Response to Miner et al.

por Currie, Mark G, Shiff, Steven J, Schneier, Harvey A, Johnston, Jeffrey M
Publicado 2017

Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

por Behrouzi, Reza, Lu, Chenning, Currie, Mark A, Jih, Gloria, Iglesias, Nahid, Moazed, Danesh
Publicado 2016

Hyperhemolysis in the Setting of Mixed-Autoimmune Hemolytic Anemia: A Rare Complication of COVID-19

por Narula, Sonya, Winkle, Sean, Brand, Kenneth, Shah, Farhan, Fujikawa, Priscilla, Truitt, Tyler, Currie, Mark
Publicado 2021

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

por Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B., Bryant, Alexander P., Currie, Mark G., Silos-Santiago, Inmaculada
Publicado 2014

SUN-662 Praliciguat, a Clinical-Stage Soluble Guanylate Cyclase Stimulator, Improves Lipid Handling and Insulin Sensitivity in Diet-Induced Obese Mice

por Schwartzkopf, Chad D, Liu, Guang, Hadcock, John R, Currie, Mark G, Masferrer, Jamie L, Jones, Juli E
Publicado 2020

Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases

por Currie, Mark A., Brown, Greg, Wong, Andrew, Ohira, Takayuki, Sugiyama, Kei, Suzuki, Tsutomu, Yakunin, Alexander F., Jia, Zongchao
Publicado 2017

Automethylation-induced conformational switch in Clr4/Suv39h maintains epigenetic stability

por Iglesias, Nahid, Currie, Mark A., Jih, Gloria, Paulo, Joao A., Siuti, Nertila, Kalocsay, Marian, Gygi, Steven P., Moazed, Danesh
Publicado 2018

Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins

por Wong, Samantha J., Ringel, Alison E., Yuan, William, Paulo, Joao A., Yoon, Haejin, Currie, Mark A., Haigis, Marcia C.
Publicado 2021

Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

por Elkhatib, Wassim, Yanez-Guerra, Luis A., Mayorova, Tatiana D., Currie, Mark A., Singh, Anhadvir, Perera, Maria, Gauberg, Julia, Senatore, Adriano
Publicado 2023

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

por Jih, Gloria, Iglesias, Nahid, Currie, Mark A., Bhanu, Natarajan V., Paulo, Joao A., Gygi, Steven P., Garcia, Benjamin A., Moazed, Danesh
Publicado 2017

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

por Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.
Publicado 2019

High‐dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double‐blind, placebo‐controlled study with a long‐term open‐label extens...

por Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Kinoshita, Yoshikazu, Kosako, Masanori, Hayashi, Kenta, Akiho, Hiraku, Kuroishi, Kentaro, Johnston, Jeffrey M, Currie, Mark, Ohkusa, Toshifumi
Publicado 2018

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

por Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Publicado 2020

The soluble guanylate cyclase stimulator IW‐1973 prevents inflammation and fibrosis in experimental non‐alcoholic steatohepatitis

por Flores‐Costa, Roger, Alcaraz‐Quiles, José, Titos, Esther, López‐Vicario, Cristina, Casulleras, Mireia, Duran‐Güell, Marta, Rius, Bibiana, Diaz, Alba, Hall, Katherine, Shea, Courtney, Sarno, Renee, Currie, Mark, Masferrer, Jaime L, Clària, Joan
Publicado 2018

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

por Lacy, Brian E., Schey, Ron, Shiff, Steven J., Lavins, Bernard J., Fox, Susan M., Jia, Xinwei D., Blakesley, Rick E., Hao, Xinming, Cronin, Jacquelyn A., Currie, Mark G., Kurtz, Caroline B., Johnston, Jeffrey M., Lembo, Anthony J.
Publicado 2015

Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

por Schoenfeld, Philip, Lacy, Brian E, Chey, William D, Lembo, Anthony J, Kurtz, Caroline B, Reasner, David S, Bochenek, Wieslaw, Tripp, Kenneth, Currie, Mark G, Fox, Susan M, Blakesley, Rick E, O’Dea, Christopher R, Omniewski, Nicholas D, Hall, Michael L
Publicado 2018