DNAJB12 and Hsp70 Mediate Triage of Misfolded Membrane Proteins for Proteasomal versus Lysosomal Degradation

por Kennedy, Andrew, Cyr, Douglas M.
Publicado 2022

The role of the UPS in cystic fibrosis

por Turnbull, Emma L, Rosser, Meredith FN, Cyr, Douglas M
Publicado 2007

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

por Wolfe, Katie J., Ren, Hong Yu, Trepte, Philipp, Cyr, Douglas M.
Publicado 2013

Polyglutamine-Rich Suppressors of Huntingtin Toxicity Act Upstream of Hsp70 and Sti1 in Spatial Quality Control of Amyloid-Like Proteins

por Wolfe, Katie J., Ren, Hong Yu, Trepte, Philipp, Cyr, Douglas M.
Publicado 2014

Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin

por Kennedy, Andrew, Ren, Hong Yu, Madden, Victoria J., Cyr, Douglas M.
Publicado 2022

The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

por Grove, Diane E., Fan, Chun-Yang, Ren, Hong Yu, Cyr, Douglas M.
Publicado 2011

The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein

por Summers, Daniel W., Wolfe, Katie J., Ren, Hong Yu, Cyr, Douglas M.
Publicado 2013

Central domain deletions affect the SAXS solution structure and function of Yeast Hsp40 proteins Sis1 and Ydj1

por Silva, Julio C, Borges, Julio C, Cyr, Douglas M, Ramos, Carlos HI, Torriani, Iris L
Publicado 2011

A foldable CFTRΔF508 biogenic intermediate accumulates upon inhibition of the Hsc70–CHIP E3 ubiquitin ligase

por Younger, J. Michael, Ren, Hong-Yu, Chen, Liling, Fan, Chun-Yang, Fields, Andrea, Patterson, Cam, Cyr, Douglas M.
Publicado 2004

Identification of Regions Involved in Substrate Binding and Dimer Stabilization within the Central Domains of Yeast Hsp40 Sis1

por Borges, Júlio C., Seraphim, Thiago V., Mokry, David Z., Almeida, Fabio C. L., Cyr, Douglas M., Ramos, Carlos H. I.
Publicado 2012

Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter

por Suzuki, Shingo, Shuto, Tsuyoshi, Sato, Takashi, Kaneko, Masayuki, Takada, Tappei, Suico, Mary Ann, Cyr, Douglas M., Suzuki, Hiroshi, Kai, Hirofumi
Publicado 2014

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

por Ren, Hong Yu, Grove, Diane E., De La Rosa, Oxana, Houck, Scott A., Sopha, Pattarawut, Van Goor, Fredrick, Hoffman, Beth J., Cyr, Douglas M.
Publicado 2013

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

por Nillegoda, Nadinath B., Theodoraki, Maria A., Mandal, Atin K., Mayo, Katie J., Ren, Hong Yu, Sultana, Rasheda, Wu, Kenneth, Johnson, Jill, Cyr, Douglas M., Caplan, Avrom J.
Publicado 2010

DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy

por He, Lihua, Kennedy, Andrew S., Houck, Scott, Aleksandrov, Andrei, Quinney, Nancy L., Cyr-Scully, Alexandra, Cholon, Deborah M., Gentzsch, Martina, Randell, Scott H., Ren, Hong Yu, Cyr, Douglas M.
Publicado 2021

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

por Veit, Gudio, Avramescu, Radu G., Chiang, Annette N., Houck, Scott A., Cai, Zhiwei, Peters, Kathryn W., Hong, Jeong S., Pollard, Harvey B., Guggino, William B., Balch, William E., Skach, William R., Cutting, Garry R., Frizzell, Raymond A., Sheppard, David N., Cyr, Douglas M., Sorscher, Eric J., Brodsky, Jeffrey L., Lukacs, Gergely L.
Publicado 2016