A new crystal form of GABARAPL2

por Scicluna, Kristen, Dewson, Grant, Czabotar, Peter E., Birkinshaw, Richard W.
Publicado 2021

VDAC2 and the BCL-2 family of proteins

por Yuan, Zheng, Dewson, Grant, Czabotar, Peter E., Birkinshaw, Richard W.
Publicado 2021

Relating SMCHD1 structure to its function in epigenetic silencing

por Gurzau, Alexandra D., Blewitt, Marnie E., Czabotar, Peter E., Murphy, James M., Birkinshaw, Richard W.
Publicado 2020

From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

por Gardner, Christopher R., Davies, Katherine A., Zhang, Ying, Brzozowski, Martin, Czabotar, Peter E., Murphy, James M., Lessene, Guillaume
Publicado 2023

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

por Meng, Yanxiang, Horne, Christopher R., Samson, Andre L., Dagley, Laura F., Young, Samuel N., Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Publicado 2022

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

por Lee, Erinna F., Czabotar, Peter E., van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., Puthalakath, Hamsa, Bouillet, Philippe, Colman, Peter M., Huang, David C.S., Fairlie, W. Douglas
Publicado 2008

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

por Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.
Publicado 2019

Ion currents through Kir potassium channels are gated by anionic lipids

por Jin, Ruitao, He, Sitong, Black, Katrina A., Clarke, Oliver B., Wu, Di, Bolla, Jani R., Johnson, Paul, Periasamy, Agalya, Wardak, Ahmad, Czabotar, Peter, Colman, Peter M., Robinson, Carol V., Laver, Derek, Smith, Brian J., Gulbis, Jacqueline M.
Publicado 2022

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

por Bandala-Sanchez, Esther, G. Bediaga, Naiara, Goddard-Borger, Ethan D., Ngui, Katrina, Naselli, Gaetano, Stone, Natalie L., Neale, Alana M., Pearce, Lesley A., Wardak, Ahmad, Czabotar, Peter, Haselhorst, Thomas, Maggioni, Andrea, Hartley-Tassell, Lauren A., Adams, Timothy E., Harrison, Leonard C.
Publicado 2018

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

por Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Publicado 2021

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

por Lee, Erinna F., Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M., Debrincat, Marlyse A., Gray, Daniel H., Witkowski, Matthew T., Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M., Czabotar, Peter E., Colman, Peter M., Smith, Brian J., Kile, Benjamin T., Fairlie, W. Douglas
Publicado 2016

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

por Healer, Julie, Wong, Wilson, Thompson, Jennifer K., He, Wengqiang, Birkinshaw, Richard W., Miura, Kazutoyo, Long, Carol A., Soroka, Vladislav, Søgaard, Teit Max Moscote, Jørgensen, Thomas, de Jongh, Willem A., Weir, Christopher, Svahn, Ella, Czabotar, Peter E., Tham, Wai‐Hong, Mueller, Ivo, Barlow, Paul N., Cowman, Alan F.
Publicado 2019

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

por Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Yeung, Wayland, Coursier, Diane, Birkinshaw, Richard W., Sandow, Jarrod J., Lehmann, Wil I. L., Liang, Lung-Yu, Lucet, Isabelle S., Chalmers, James D., Patrick, Wayne M., Kannan, Natarajan, Petrie, Emma J., Czabotar, Peter E., Murphy, James M.
Publicado 2020

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization

por Meng, Yanxiang, Garnish, Sarah E., Davies, Katherine A., Black, Katrina A., Leis, Andrew P., Horne, Christopher R., Hildebrand, Joanne M., Hoblos, Hanadi, Fitzgibbon, Cheree, Young, Samuel N., Dite, Toby, Dagley, Laura F., Venkat, Aarya, Kannan, Natarajan, Koide, Akiko, Koide, Shohei, Glukhova, Alisa, Czabotar, Peter E., Murphy, James M.
Publicado 2023

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

por Moghaddas, Fiona, Zeng, Ping, Zhang, Yuxia, Schützle, Heike, Brenner, Sebastian, Hofmann, Sigrun R., Berner, Reinhard, Zhao, Yuanbo, Lu, Bingtai, Chen, Xiaoyun, Zhang, Li, Cheng, Suyun, Winkler, Stefan, Lehmberg, Kai, Canna, Scott W., Czabotar, Peter E., Wicks, Ian P., De Nardo, Dominic, Hedrich, Christian M., Zeng, Huasong, Masters, Seth L.
Publicado 2018

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

por Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Publicado 2021

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

por Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.
Publicado 2018

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

por Calleja, Dale J., Kuchel, Nathan, Lu, Bernadine G. C., Birkinshaw, Richard W., Klemm, Theresa, Doerflinger, Marcel, Cooney, James P., Mackiewicz, Liana, Au, Amanda E., Yap, Yu Q., Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E., Call, Melissa J., Lechtenberg, Bernhard C., Czabotar, Peter E., Pellegrini, Marc, Charman, Susan A., Lowes, Kym N., Mitchell, Jeffrey P., Nachbur, Ueli, Lessene, Guillaume, Komander, David
Publicado 2022

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

por Tullett, Kirsteen M, Tan, Peck Szee, Park, Hae-Young, Schittenhelm, Ralf B, Michael, Nicole, Li, Rong, Policheni, Antonia N, Gruber, Emily, Huang, Cheng, Fulcher, Alex J, Danne, Jillian C, Czabotar, Peter E, Wakim, Linda M, Mintern, Justine D, Ramm, Georg, Radford, Kristen J, Caminschi, Irina, O'Keeffe, Meredith, Villadangos, Jose A, Wright, Mark D, Blewitt, Marnie E, Heath, William R, Shortman, Ken, Purcell, Anthony W, Nicola, Nicos A, Zhang, Jian-Guo, Lahoud, Mireille H
Publicado 2020

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

por Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Publicado 2020