Alternative Approaches to Understand Microtubule Cap Morphology and Function

por Oliva, María Ángela, Gago, Federico, Kamimura, Shinji, Díaz, J. Fernando
Publicado 2023

The Diamagnetic Susceptibility of the Tubulin Dimer

por Bras, Wim, Torbet, James, Diakun, Gregory P., Rikken, Geert L. J. A., Diaz, J. Fernando
Publicado 2014

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

por Field, Jessica J., Northcote, Peter T., Paterson, Ian, Altmann, Karl-Heinz, Díaz, J. Fernando, Miller, John H.
Publicado 2017

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate

por Gaugaz, Fabienne Zdenka, Chicca, Andrea, Redondo-Horcajo, Mariano, Barasoain, Isabel, Díaz, J. Fernando, Altmann, Karl-Heinz
Publicado 2019

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin

por Sharma, Ashwani, Sáez-Calvo, Gonzalo, Olieric, Natacha, de Asís Balaguer, Francisco, Barasoain, Isabel, Lamberth, Clemens, Díaz, J. Fernando, Steinmetz, Michel O.
Publicado 2017

Structural and Functional Insights Into Skl and Pal Endolysins, Two Cysteine-Amidases With Anti-pneumococcal Activity. Dithiothreitol (DTT) Effect on Lytic Activity

por Gallego-Páramo, Cristina, Hernández-Ortiz, Noelia, Buey, Rubén M., Rico-Lastres, Palma, García, Guadalupe, Díaz, J. Fernando, García, Pedro, Menéndez, Margarita
Publicado 2021

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

por Jantsch, Andrea, Nieto, Lidia, Gertsch, Jürg, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Jiménez-Barbero, Jesús, Díaz, J. Fernando, Canales, Ángeles, Altmann, Karl-Heinz
Publicado 2016

Cytotoxic Activity and Chemical Composition of the Root Extract from the Mexican Species Linum scabrellum: Mechanism of Action of the Active Compound 6-Methoxypodophyllotoxin

por Alejandre-García, Ivonne, Álvarez, Laura, Cardoso-Taketa, Alexandre, González-Maya, Leticia, Antúnez, Mayra, Salas-Vidal, Enrique, Díaz, J. Fernando, Marquina-Bahena, Silvia, Villarreal, María Luisa
Publicado 2015

Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes

por Rai, Ankit, Liu, Tianyang, Katrukha, Eugene A., Estévez-Gallego, Juan, Manka, Szymon W., Paterson, Ian, Díaz, J. Fernando, Kapitein, Lukas C., Moores, Carolyn A., Akhmanova, Anna
Publicado 2021

Tannic Acid and Ethyl Gallate Potentialize Paclitaxel Effect on Microtubule Dynamics in Hep3B Cells

por Sánchez-Carranza, Jessica Nayelli, Redondo-Horcajo, Mariano, Barasoain, Isabel, Escobar-Aguilar, Ever Angel, Millán-Pacheco, César, Alvarez, Laura, Salas Vidal, Enrique, Diaz, J. Fernando, Gonzalez-Maya, Leticia
Publicado 2023

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

por Menchon, Grégory, Prota, Andrea E., Lucena-Agell, Daniel, Bucher, Pascal, Jansen, Rolf, Irschik, Herbert, Müller, Rolf, Paterson, Ian, Díaz, J. Fernando, Altmann, Karl-Heinz, Steinmetz, Michel O.
Publicado 2018

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders

por Marzullo, Paola, Boiarska, Zlata, Pérez‐Peña, Helena, Abel, Anne‐Catherine, Álvarez‐Bernad, Beatriz, Lucena‐Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Altmann, Karl‐Heinz, Prota, Andrea E., Díaz, J. Fernando, Pieraccini, Stefano, Passarella, Daniele
Publicado 2021

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

por Bueno, Oskía, Estévez Gallego, Juan, Martins, Solange, Prota, Andrea E., Gago, Federico, Gómez-SanJuan, Asier, Camarasa, María-José, Barasoain, Isabel, Steinmetz, Michel O., Díaz, J. Fernando, Pérez-Pérez, María-Jesús, Liekens, Sandra, Priego, Eva-María
Publicado 2018

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

por Trigili, Chiara, Barasoain, Isabel, Sánchez-Murcia, Pedro A., Bargsten, Katja, Redondo-Horcajo, Mariano, Nogales, Aurora, Gardner, Nicola M., Meyer, Arndt, Naylor, Guy J., Gómez-Rubio, Elena, Gago, Federico, Steinmetz, Michel O., Paterson, Ian, Prota, Andrea E., Díaz, J. Fernando
Publicado 2016

Structural insight into the stabilization of microtubules by taxanes

por Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando
Publicado 2023

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

por Balaguer, Francisco de Asís, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan Francisco, Risinger, April L., Sorensen, Erik J., Vanderwal, Christopher D., Altmann, Karl-Heinz, Mooberry, Susan L., Steinmetz, Michel O., Oliva, María Ángela, Prota, Andrea E., Díaz, J. Fernando
Publicado 2019

Structural model for differential cap maturation at growing microtubule ends

por Estévez-Gallego, Juan, Josa-Prado, Fernando, Ku, Siou, Buey, Ruben M, Balaguer, Francisco A, Prota, Andrea E, Lucena-Agell, Daniel, Kamma-Lorger, Christina, Yagi, Toshiki, Iwamoto, Hiroyuki, Duchesne, Laurence, Barasoain, Isabel, Steinmetz, Michel O, Chrétien, Denis, Kamimura, Shinji, Díaz, J Fernando, Oliva, Maria A
Publicado 2020

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

por Bohnacker, Thomas, Prota, Andrea E., Beaufils, Florent, Burke, John E., Melone, Anna, Inglis, Alison J., Rageot, Denise, Sele, Alexander M., Cmiljanovic, Vladimir, Cmiljanovic, Natasa, Bargsten, Katja, Aher, Amol, Akhmanova, Anna, Díaz, J. Fernando, Fabbro, Doriano, Zvelebil, Marketa, Williams, Roger L., Steinmetz, Michel O., Wymann, Matthias P.
Publicado 2017

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

por Peronne, Lauralie, Denarier, Eric, Rai, Ankit, Prudent, Renaud, Vernet, Audrey, Suzanne, Peggy, Ramirez-Rios, Sacnicté, Michallet, Sophie, Guidetti, Mélanie, Vollaire, Julien, Lucena-Agell, Daniel, Ribba, Anne-Sophie, Josserand, Véronique, Coll, Jean-Luc, Dallemagne, Patrick, Díaz, J. Fernando, Oliva, María Ángela, Sadoul, Karin, Akhmanova, Anna, Andrieux, Annie, Lafanechère, Laurence
Publicado 2020