Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells

por Dickerson, Matthew T., Vierra, Nicholas C., Milian, Sarah C., Dadi, Prasanna K., Jacobson, David A.
Publicado 2017

Type 2 Diabetes–Associated K(+) Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

por Vierra, Nicholas C., Dadi, Prasanna K., Jeong, Imju, Dickerson, Matthew, Powell, David R., Jacobson, David A.
Publicado 2015

Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function

por Kuo, Taiyi, Du, Wen, Miyachi, Yasutaka, Dadi, Prasanna K., Jacobson, David A., Segrè, Daniel, Accili, Domenico
Publicado 2021

Cytokine-mediated changes in K(+) channel activity promotes an adaptive Ca(2+) response that sustains β-cell insulin secretion during inflammation

por Dickerson, Matthew T., Bogart, Avery M., Altman, Molly K., Milian, Sarah C., Jordan, Kelli L., Dadi, Prasanna K., Jacobson, David A.
Publicado 2018

OR28-3 A Mutation in KCNK16 Segregating with Autosomal Dominant Non-Ketotic Diabetes Drastically Increases TALK-1 Membrane Current: A Novel Gene for MODY?

por Johnson, Stephanie, Graff, Sarah, Dadi, Prasanna, Marshall, Mhairi, Leo, Paul, McInerney-Leo, Aideen, Brown, Matthew, Jacobson, David, Duncan, Emma
Publicado 2019

The MODY-associated TALK-1 L114P mutation causes islet α-cell overactivity and β-cell inactivity resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

por Nakhe, Arya Y., Dadi, Prasanna K., Kim, Jinsun, Shrestha, Shristi, Cartailler, Jean-Philippe, Sampson, Leesa, Magnuson, Mark A., Jacobson, David A.
Publicado 2023

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

por Golson, Maria L., Dunn, Jennifer C., Maulis, Matthew F., Dadi, Prasanna K., Osipovich, Anna B., Magnuson, Mark A., Jacobson, David A., Gannon, Maureen
Publicado 2015

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion

por Vierra, Nicholas C., Dickerson, Matthew T., Jordan, Kelli L., Dadi, Prasanna K., Kadare, Ketaki A., Altman, Molly K., Milian, Sarah C., Jacobson, David A.
Publicado 2018

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes

por Stancill, Jennifer S., Cartailler, Jean-Philippe, Clayton, Hannah W., O’Connor, James T., Dickerson, Matthew T., Dadi, Prasanna K., Osipovich, Anna B., Jacobson, David A., Magnuson, Mark A.
Publicado 2017

Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation

por Sanavia, Tiziana, Huang, Chen, Manduchi, Elisabetta, Xu, Yanwen, Dadi, Prasanna K., Potter, Leah A., Jacobson, David A., Di Camillo, Barbara, Magnuson, Mark A., Stoeckert, Christian J., Gu, Guoqiang
Publicado 2021

Lactate activation of α-cell K(ATP) channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca(2+) entry

por Zaborska, Karolina E., Dadi, Prasanna K., Dickerson, Matthew T., Nakhe, Arya Y., Thorson, Ariel S., Schaub, Charles M., Graff, Sarah M., Stanley, Jade E., Kondapavuluru, Roy S., Denton, Jerod S., Jacobson, David A.
Publicado 2020

G(i/o) protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na(+)/K(+) ATPase activation

por Dickerson, Matthew T., Dadi, Prasanna K., Zaborska, Karolina E., Nakhe, Arya Y., Schaub, Charles M., Dobson, Jordyn R., Wright, Nicole M., Lynch, Joshua C., Scott, Claire F., Robinson, Logan D., Jacobson, David A.
Publicado 2022

G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion

por Pound, Lynley D., Oeser, James K., O’Brien, Tracy P., Wang, Yingda, Faulman, Chandler J., Dadi, Prasanna K., Jacobson, David A., Hutton, John C., McGuinness, Owen P., Shiota, Masakazu, O’Brien, Richard M.
Publicado 2013

A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young

por Graff, Sarah M., Johnson, Stephanie R., Leo, Paul J., Dadi, Prasanna K., Dickerson, Matthew T., Nakhe, Arya Y., McInerney-Leo, Aideen M., Marshall, Mhairi, Zaborska, Karolina E., Schaub, Charles M., Brown, Matthew A., Jacobson, David A., Duncan, Emma L.
Publicado 2021

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

por Pound, Lynley D., Sarkar, Suparna A., Ustione, Alessandro, Dadi, Prasanna K., Shadoan, Melanie K., Lee, Catherine E., Walters, Jay A., Shiota, Masakazu, McGuinness, Owen P., Jacobson, David A., Piston, David W., Hutton, John C., Powell, David R., O’Brien, Richard M.
Publicado 2012

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

por Zhu, Lu, Almaça, Joana, Dadi, Prasanna K., Hong, Hao, Sakamoto, Wataru, Rossi, Mario, Lee, Regina J., Vierra, Nicholas C., Lu, Huiyan, Cui, Yinghong, McMillin, Sara M., Perry, Nicole A., Gurevich, Vsevolod V., Lee, Amy, Kuo, Bryan, Leapman, Richard D., Matschinsky, Franz M., Doliba, Nicolai M., Urs, Nikhil M., Caron, Marc G., Jacobson, David A., Caicedo, Alejandro, Wess, Jürgen
Publicado 2017