The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS

por Dafinca, Ruxandra, Barbagallo, Paola, Talbot, Kevin
Publicado 2021

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD

por Dafinca, Ruxandra, Barbagallo, Paola, Farrimond, Lucy, Candalija, Ana, Scaber, Jakub, Ababneh, Nida'a A., Sathyaprakash, Chaitra, Vowles, Jane, Cowley, Sally A., Talbot, Kevin
Publicado 2020

Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins

por Altman, Topaz, Ionescu, Ariel, Ibraheem, Amjad, Priesmann, Dominik, Gradus-Pery, Tal, Farberov, Luba, Alexandra, Gayster, Shelestovich, Natalia, Dafinca, Ruxandra, Shomron, Noam, Rage, Florence, Talbot, Kevin, Ward, Michael E., Dori, Amir, Krüger, Marcus, Perlson, Eran
Publicado 2021

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons

por Vahsen, Björn F., Gray, Elizabeth, Candalija, Ana, Cramb, Kaitlyn M. L., Scaber, Jakub, Dafinca, Ruxandra, Katsikoudi, Antigoni, Xu, Yinyan, Farrimond, Lucy, Wade-Martins, Richard, James, William S., Turner, Martin R., Cowley, Sally A., Talbot, Kevin
Publicado 2022

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell‐Derived Neuron...

por Dafinca, Ruxandra, Scaber, Jakub, Ababneh, Nida'a, Lalic, Tatjana, Weir, Gregory, Christian, Helen, Vowles, Jane, Douglas, Andrew G.L., Fletcher‐Jones, Alexandra, Browne, Cathy, Nakanishi, Mahito, Turner, Martin R., Wade‐Martins, Richard, Cowley, Sally A., Talbot, Kevin
Publicado 2016

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

por Vahsen, Björn F., Nalluru, Sumedha, Morgan, Georgia R., Farrimond, Lucy, Carroll, Emily, Xu, Yinyan, Cramb, Kaitlyn M. L., Amein, Benazir, Scaber, Jakub, Katsikoudi, Antigoni, Candalija, Ana, Carcolé, Mireia, Dafinca, Ruxandra, Isaacs, Adrian M., Wade-Martins, Richard, Gray, Elizabeth, Turner, Martin R., Cowley, Sally A., Talbot, Kevin
Publicado 2023