Drug delivery systems for RNA therapeutics

por Paunovska, Kalina, Loughrey, David, Dahlman, James E.
Publicado 2022

Dataset of bond enthalpies (ε(AA), ε(AB), ε(BB)) in 975 binary intermetallic compounds

por Miracle, Daniel, Dahlman, Amanda, Wilks, Garth, Dahlman, James E.
Publicado 2021

Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease

por Dahlman, James E., Abudayyeh, Omar O., Joung, Julia, Gootenberg, Jonathan S., Zhang, Feng, Konermann, Silvana
Publicado 2015

Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis

por Budatha, Madhusudhan, Zhang, Jiasheng, Zhuang, Zhen W., Yun, Sanguk, Dahlman, James E., Anderson, Daniel G., Schwartz, Martin A.
Publicado 2018

Barcoding chemical modifications into nucleic acids improves drug stability in vivo

por Sago, Cory D., Kalathoor, Sujay, Fitzgerald, Jordan P., Lando, Gwyneth N., Djeddar, Naima, Bryksin, Anton V., Dahlman, James E.
Publicado 2018

Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

por Gan, Zubao, Lokugamage, Melissa P., Hatit, Marine Z. C., Loughrey, David, Paunovska, Kalina, Sato, Manaka, Cristian, Ana, Dahlman, James E.
Publicado 2020

Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing

por Brown, Jonathan M., Dahlman, James E., Neuman, Kristin K., Prata, Carla A.H., Krampert, Monika C., Hadwiger, Philipp M., Vornlocher, Hans-Peter
Publicado 2019

Increased PIP3 activity blocks nanoparticle mRNA delivery

por Paunovska, Kalina, Da Silva Sanchez, Alejandro, Foster, Matthew T., Loughrey, David, Blanchard, Emmeline L., Islam, Fatima Z., Gan, Zubao, Mantalaris, Athanasios, Santangelo, Philip J., Dahlman, James E.
Publicado 2020

Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

por Ni, Huanzhen, Hatit, Marine Z. C., Zhao, Kun, Loughrey, David, Lokugamage, Melissa P., Peck, Hannah E., Cid, Ada Del, Muralidharan, Abinaya, Kim, YongTae, Santangelo, Philip J., Dahlman, James E.
Publicado 2022

Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo

por Jongejan, Yvonne K., Schrader Echeverri, Elisa, Dirven, Richard J., Paunovska, Kalina, Linthorst, Noa A., de Jong, Annika, Wellershoff, Johannes C., van der Gouw, Kim D., van Vlijmen, Bart J. M., Dahlman, James E., Eikenboom, Jeroen C. J.
Publicado 2023

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration

por Herr, Keira Joann, Tsang, Ying-hung Nicole, Ong, Joanne Wei En, Li, Qiushi, Yap, Lai Lai, Yu, Weimiao, Yin, Hao, Bogorad, Roman L., Dahlman, James E., Chan, Yee Gek, Bay, Boon Huat, Singaraja, Roshni, Anderson, Daniel G., Koteliansky, Victor, Viasnoff, Virgile, Thiery, Jean Paul
Publicado 2014

The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo

por Radmand, Afsane, Lokugamage, Melissa P., Kim, Hyejin, Dobrowolski, Curtis, Zenhausern, Ryan, Loughrey, David, Huayamares, Sebastian G., Hatit, Marine Z. C., Ni, Huanzhen, Del Cid, Ada, Da Silva Sanchez, Alejandro J., Paunovska, Kalina, Schrader Echeverri, Elisa, Shajii, Aram, Peck, Hannah, Santangelo, Philip J., Dahlman, James E.
Publicado 2023

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

por Sago, Cory D., Lokugamage, Melissa P., Paunovska, Kalina, Vanover, Daryll A., Monaco, Christopher M., Shah, Nirav N., Gamboa Castro, Marielena, Anderson, Shannon E., Rudoltz, Tobi G., Lando, Gwyneth N., Munnilal Tiwari, Pooja, Kirschman, Jonathan L., Willett, Nick, Jang, Young C., Santangelo, Philip J., Bryksin, Anton V., Dahlman, James E.
Publicado 2018

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis

por Chen, Pei-Yu, Qin, Lingfeng, Li, Guangxin, Wang, Zheng, Dahlman, James E., Malagon-Lopez, Jose, Gujja, Sharvari, Cilfone, Nicholas A., Kauffman, Kevin J., Sun, Lele, Sun, Hongye, Zhang, Xinbo, Aryal, Binod, Canfran-Duque, Alberto, Liu, Rebecca, Kusters, Pascal, Sehgal, Alfica, Jiao, Yang, Anderson, Daniel G., Gulcher, Jeffrey, Fernandez-Hernando, Carlos, Lutgens, Esther, Schwartz, Martin A., Pober, Jordan S., Chittenden, Thomas W., Tellides, George, Simons, Michael
Publicado 2019

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension

por White, Kevin, Lu, Yu, Annis, Sofia, Hale, Andrew E, Chau, B Nelson, Dahlman, James E, Hemann, Craig, Opotowsky, Alexander R, Vargas, Sara O, Rosas, Ivan, Perrella, Mark A, Osorio, Juan C, Haley, Kathleen J, Graham, Brian B, Kumar, Rahul, Saggar, Rajan, Saggar, Rajeev, Wallace, W Dean, Ross, David J, Khan, Omar F, Bader, Andrew, Gochuico, Bernadette R, Matar, Majed, Polach, Kevin, Johannessen, Nicolai M, Prosser, Haydn M, Anderson, Daniel G, Langer, Robert, Zweier, Jay L, Bindoff, Laurence A, Systrom, David, Waxman, Aaron B, Jin, Richard C, Chan, Stephen Y
Publicado 2015

The NIH Somatic Cell Genome Editing program

por Saha, Krishanu, Sontheimer, Erik J., Brooks, P. J., Dwinell, Melinda R., Gersbach, Charles A., Liu, David R., Murray, Stephen A., Tsai, Shengdar Q., Wilson, Ross C., Anderson, Daniel G., Asokan, Aravind, Banfield, Jillian F., Bankiewicz, Krystof S., Bao, Gang, Bulte, Jeff W. M., Bursac, Nenad, Campbell, Jarryd M., Carlson, Daniel F., Chaikof, Elliot L., Chen, Zheng-Yi, Cheng, R. Holland, Clark, Karl J., Curiel, David T., Dahlman, James E., Deverman, Benjamin E., Dickinson, Mary E., Doudna, Jennifer A., Ekker, Stephen C., Emborg, Marina E., Feng, Guoping, Freedman, Benjamin S., Gamm, David M., Gao, Guangping, Ghiran, Ionita C., Glazer, Peter M., Gong, Shaoqin, Heaney, Jason D., Hennebold, Jon D., Hinson, John T., Khvorova, Anastasia, Kiani, Samira, Lagor, William R., Lam, Kit S., Leong, Kam W., Levine, Jon E., Lewis, Jennifer A., Lutz, Cathleen M., Ly, Danith H., Maragh, Samantha, McCray, Paul B., McDevitt, Todd C., Mirochnitchenko, Oleg, Morizane, Ryuji, Murthy, Niren, Prather, Randall S., Ronald, John A., Roy, Subhojit, Roy, Sushmita, Sabbisetti, Venkata, Saltzman, W. Mark, Santangelo, Philip J., Segal, David J., Shimoyama, Mary, Skala, Melissa C., Tarantal, Alice F., Tilton, John C., Truskey, George A., Vandsburger, Moriel, Watts, Jonathan K., Wells, Kevin D., Wolfe, Scot A., Xu, Qiaobing, Xue, Wen, Yi, Guohua, Zhou, Jiangbing
Publicado 2021