The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression

por Ge, Yunjun, Yang, Dehua, Dai, Antao, Zhou, Caihong, Zhu, Yue, Wang, Ming-Wei
Publicado 2014

Identification of a carbohydrate recognition motif of purinergic receptors

por Zhao, Lifen, Wei, Fangyu, He, Xinheng, Dai, Antao, Yang, Dehua, Jiang, Hualiang, Wen, Liuqing, Cheng, Xi
Publicado 2023

Structural analysis of the dual agonism at GLP-1R and GCGR

por Li, Yang, Zhou, Qingtong, Dai, Antao, Zhao, Fenghui, Chang, Rulue, Ying, Tianlei, Wu, Beili, Yang, Dehua, Wang, Ming-Wei, Cong, Zhaotong
Publicado 2023

Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening

por Zhou, Qingtong, Guo, Wanjing, Dai, Antao, Cai, Xiaoqing, Vass, Márton, de Graaf, Chris, Shui, Wenqing, Zhao, Suwen, Yang, Dehua, Wang, Ming-Wei
Publicado 2021

DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening

por Wan, Fangping, Zhu, Yue, Hu, Hailin, Dai, Antao, Cai, Xiaoqing, Chen, Ligong, Gong, Haipeng, Xia, Tian, Yang, Dehua, Wang, Ming-Wei, Zeng, Jianyang
Publicado 2019

Molecular basis of signal transduction mediated by the human GIPR splice variants

por Zhao, Fenghui, Hang, Kaini, Zhou, Qingtong, Shao, Lijun, Li, Hao, Li, Wenzhuo, Lin, Shi, Dai, Antao, Cai, Xiaoqing, Liu, Yanyun, Xu, Yingna, Feng, Wenbo, Yang, Dehua, Wang, Ming-Wei
Publicado 2023

Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

por Feng, Wenbo, Zhou, Qingtong, Chen, Xianyue, Dai, Antao, Cai, Xiaoqing, Liu, Xiao, Zhao, Fenghui, Chen, Yan, Ye, Chenyu, Xu, Yingna, Cong, Zhaotong, Li, Hao, Lin, Shi, Yang, Dehua, Wang, Ming-Wei
Publicado 2023

Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24

por Cong, Zhaotong, Zhou, Qingtong, Li, Yang, Chen, Li-Nan, Zhang, Zi-Chen, Liang, Anyi, Liu, Qing, Wu, Xiaoyan, Dai, Antao, Xia, Tian, Wu, Wei, Zhang, Yan, Yang, Dehua, Wang, Ming-Wei
Publicado 2022

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

por Wang, Xi, Cheng, Xi, Zhao, Lihua, Wang, Yuzhe, Ye, Chenyu, Zou, Xinyu, Dai, Antao, Cong, Zhaotong, Chen, Jian, Zhou, Qingtong, Xia, Tian, Jiang, Hualiang, Xu, H. Eric, Yang, Dehua, Wang, Ming-Wei
Publicado 2021

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

por Liu, Qiufeng, Yang, Dehua, Zhuang, Youwen, Croll, Tristan I., Cai, Xiaoqing, Dai, Antao, He, Xinheng, Duan, Jia, Yin, Wanchao, Ye, Chenyu, Zhou, Fulai, Wu, Beili, Zhao, Qiang, Xu, H. Eric, Wang, Ming-Wei, Jiang, Yi
Publicado 2021

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

por Xu, Yingna, Feng, Wenbo, Zhou, Qingtong, Liang, Anyi, Li, Jie, Dai, Antao, Zhao, Fenghui, Yan, Jiahui, Chen, Chuan-Wei, Li, Hao, Zhao, Li-Hua, Xia, Tian, Jiang, Yi, Xu, H. Eric, Yang, Dehua, Wang, Ming-Wei
Publicado 2022

Common activation mechanism of class A GPCRs

por Zhou, Qingtong, Yang, Dehua, Wu, Meng, Guo, Yu, Guo, Wanjing, Zhong, Li, Cai, Xiaoqing, Dai, Antao, Jang, Wonjo, Shakhnovich, Eugene I, Liu, Zhi-Jie, Stevens, Raymond C, Lambert, Nevin A, Babu, M Madan, Wang, Ming-Wei, Zhao, Suwen
Publicado 2019

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

por Cong, Zhaotong, Chen, Li-Nan, Ma, Honglei, Zhou, Qingtong, Zou, Xinyu, Ye, Chenyu, Dai, Antao, Liu, Qing, Huang, Wei, Sun, Xianqiang, Wang, Xi, Xu, Peiyu, Zhao, Lihua, Xia, Tian, Zhong, Wenge, Yang, Dehua, Eric Xu, H., Zhang, Yan, Wang, Ming-Wei
Publicado 2021

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

por Zhao, Fenghui, Zhang, Chao, Zhou, Qingtong, Hang, Kaini, Zou, Xinyu, Chen, Yan, Wu, Fan, Rao, Qidi, Dai, Antao, Yin, Wanchao, Shen, Dan-Dan, Zhang, Yan, Xia, Tian, Stevens, Raymond C, Xu, H Eric, Yang, Dehua, Zhao, Lihua, Wang, Ming-Wei
Publicado 2021

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

por Qin, Shanshan, Meng, Mengmeng, Yang, Dehua, Bai, Wenwen, Lu, Yan, Peng, Yao, Song, Gaojie, Wu, Yiran, Zhou, Qingtong, Zhao, Suwen, Huang, Xiping, McCorvy, John D., Cai, Xiaoqing, Dai, Antao, Roth, Bryan L., Hanson, Michael A., Liu, Zhi-Jie, Wang, Ming-Wei, Stevens, Raymond C., Shui, Wenqing
Publicado 2018

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

por Zhao, Fenghui, Zhou, Qingtong, Cong, Zhaotong, Hang, Kaini, Zou, Xinyu, Zhang, Chao, Chen, Yan, Dai, Antao, Liang, Anyi, Ming, Qianqian, Wang, Mu, Chen, Li-Nan, Xu, Peiyu, Chang, Rulve, Feng, Wenbo, Xia, Tian, Zhang, Yan, Wu, Beili, Yang, Dehua, Zhao, Lihua, Xu, H. Eric, Wang, Ming-Wei
Publicado 2022

Crystal structure of the human 5-HT(1B) serotonin receptor bound to an inverse agonist

por Yin, Wanchao, Zhou, X. Edward, Yang, Dehua, de Waal, Parker W., Wang, Meitian, Dai, Antao, Cai, Xiaoqing, Huang, Chia-Ying, Liu, Ping, Wang, Xiaoxi, Yin, Yanting, Liu, Bo, Zhou, Yu, Wang, Jiang, Liu, Hong, Caffrey, Martin, Melcher, Karsten, Xu, Yechun, Wang, Ming-Wei, Xu, H. Eric, Jiang, Yi
Publicado 2018

Structural basis for activation of the growth hormone-releasing hormone receptor

por Zhou, Fulai, Zhang, Huibing, Cong, Zhaotong, Zhao, Li-Hua, Zhou, Qingtong, Mao, Chunyou, Cheng, Xi, Shen, Dan-Dan, Cai, Xiaoqing, Ma, Cheng, Wang, Yuzhe, Dai, Antao, Zhou, Yan, Sun, Wen, Zhao, Fenghui, Zhao, Suwen, Jiang, Hualiang, Jiang, Yi, Yang, Dehua, Eric Xu, H., Zhang, Yan, Wang, Ming-Wei
Publicado 2020

Structural insights into ligand recognition and selectivity of somatostatin receptors

por Zhao, Wenli, Han, Shuo, Qiu, Na, Feng, Wenbo, Lu, Mengjie, Zhang, Wenru, Wang, Mu, Zhou, Qingtong, Chen, Shutian, Xu, Wei, Du, Juan, Chu, Xiaojing, Yi, Cuiying, Dai, Antao, Hu, Liaoyuan, Shen, Michelle Y., Sun, Yaping, Zhang, Qing, Ma, Yingli, Zhong, Wenge, Yang, Dehua, Wang, Ming-Wei, Wu, Beili, Zhao, Qiang
Publicado 2022

Structure of the full-length glucagon class B G protein-coupled receptor

por Zhang, Haonan, Qiao, Anna, Yang, Dehua, Yang, Linlin, Dai, Antao, de Graaf, Chris, Reedtz-Runge, Steffen, Dharmarajan, Venkatasubramanian, Zhang, Hui, Han, Gye Won, Grant, Thomas D., Sierra, Raymond G., Weierstall, Uwe, Nelson, Garrett, Liu, Wei, Wu, Yanhong, Ma, Limin, Cai, Xiaoqing, Lin, Guangyao, Wu, Xiaoai, Geng, Zhi, Dong, Yuhui, Song, Gaojie, Griffin, Patrick R., Lau, Jesper, Cherezov, Vadim, Yang, Huaiyu, Hanson, Michael A., Stevens, Raymond C., Zhao, Qiang, Jiang, Hualiang, Wang, Ming-Wei, Wu, Beili
Publicado 2017