A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding

por Yang, Jing, Lin, Sheng, Sun, Honglu, Chen, Zimin, Yang, Fanli, Lin, Xi, Guo, Liyan, Wang, Lingling, Wen, Ao, Zhang, Xindan, Dai, Yushan, He, Bin, Cao, Yu, Dong, Haohao, Liu, Xianbo, Chen, Bo, Li, Jian, Zhao, Qi, Lu, Guangwen
Publicado 2022

An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry

por Lin, Xi, Guo, Liyan, Lin, Sheng, Chen, Zimin, Yang, Fanli, Yang, Jing, Wang, Lingling, Wen, Ao, Duan, Yanping, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Lu, Guangwen
Publicado 2022

S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

por Ye, Fei, Lin, Xi, Chen, Zimin, Yang, Fanli, Lin, Sheng, Yang, Jing, Chen, Hua, Sun, Honglu, Wang, Lingling, Wen, Ao, Zhang, Xindan, Dai, Yushan, Cao, Yu, Yang, Jingyun, Shen, Guobo, Yang, Li, Li, Jiong, Wang, Zhenling, Wang, Wei, Wei, Xiawei, Lu, Guangwen
Publicado 2021

Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization

por Yang, Jing, Lin, Sheng, Chen, Zimin, Yang, Fanli, Guo, Liyan, Wang, Lingling, Duan, Yanping, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yu, Chongzhang, Yuan, Xin, Sun, Honglu, He, Bin, Cao, Yu, Ye, Haoyu, Dong, Haohao, Liu, Xianbo, Chen, Bo, Li, Jian, Zhao, Qi, Lu, Guangwen
Publicado 2023

Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruse...

por Chen, Hua, Lin, Sheng, Yang, Fanli, Chen, Zimin, Guo, Liyan, Yang, Jing, Lin, Xi, Wang, Lingling, Duan, Yanping, Wen, Ao, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Yarong, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Liu, Quan, Lu, Guangwen
Publicado 2023