P521: FINDINGS FROM AN ANALYSIS OF PATIENTS WITH MONOCYTIC AND MONOCYTIC-LIKE ACUTE MYELOID LEUKEMIA (AML), INCLUDING AML-M4 AND AML-M5, TREATED WITH VENETOCLAX (VEN) PLUS AZACITID...

por Konopleva, Marina, D. Dinardo, Courtney, Sun, Yan, Loghavi, Sanam, Jung, Paul, Potluri, Jalaja, Dail, Monique, Chyla, Brenda, A. Pollyea, Daniel
Publicado 2023

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

por Sabnis, Amit J, Cheung, Laurene S, Dail, Monique, Kang, Hio Chung, Santaguida, Marianne, Hermiston, Michelle L, Passegué, Emmanuelle, Shannon, Kevin, Braun, Benjamin S
Publicado 2009

Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras

por Akutagawa, Jon, Huang, Tannie Q., Epstein, Inbal, Chang, Tiffany, Quirindongo-Crespo, Maricel, Cottonham, Charisa L., Dail, Monique, Slusher, Barbara S., Friedman, Lori S., Sampath, Deepak, Braun, Benjamin S.
Publicado 2016

Atezolizumab alone or in combination did not demonstrate a favorable risk-benefit profile in myelodysplastic syndrome

por Gerds, Aaron T., Scott, Bart L., Greenberg, Peter, Lin, Tara L., Pollyea, Daniel A., Verma, Amit, Dail, Monique, Feng, Yuning, Green, Cherie, Ma, Connie, Medeiros, Bruno C., Yan, Mark, Yousefi, Kasra, Donnellan, William
Publicado 2022

Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias

por Huang, Benjamin J., Wandler, Anica M., Meyer, Lauren K., Dail, Monique, Daemen, Anneleen, Sampath, Deepak, Li, Qing, Wang, Xinyue, Wong, Jasmine C., Nakitandwe, Joy, Downing, James R., Zhang, Jinghui, Taylor, Barry S., Shannon, Kevin
Publicado 2019

Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models

por Mali, Raghuveer Singh, Zhang, Qi, DeFilippis, Rosa Anna, Cavazos, Antonio, Kuruvilla, Vinitha Mary, Raman, Jayant, Mody, Vidhi, Choo, Edna F., Dail, Monique, Shah, Neil P., Konopleva, Marina, Sampath, Deepak, Lasater, Elisabeth A.
Publicado 2020

Outcomes in Patients with Poor-Risk Cytogenetics with or without TP53 Mutations Treated with Venetoclax and Azacitidine

por Pollyea, Daniel A., Pratz, Keith W., Wei, Andrew H., Pullarkat, Vinod, Jonas, Brian A., Recher, Christian, Babu, Sunil, Schuh, Andre C., Dail, Monique, Sun, Yan, Potluri, Jalaja, Chyla, Brenda, DiNardo, Courtney D.
Publicado 2022

Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia

por Konopleva, Marina, Thirman, Michael J., Pratz, Keith W., Garcia, Jacqueline S., Recher, Christian, Pullarkat, Vinod, Kantarjian, Hagop M., DiNardo, Courtney D., Dail, Monique, Duan, Yinghui, Chyla, Brenda, Potluri, Jalaja, Miller, Catherine L., Wei, Andrew H.
Publicado 2022

P418: DELE1 LOSS AND DYSFUNCTIONAL INTEGRATED STRESS SIGNALING IN TP53 MUTATED AML IS A NOVEL PATHWAY FOR VENETOCLAX RESISTANCE

por Sharon, David, Jung, Paul, Sun, Yan, Feng, Weiguo, Yang, Ziping, Robinson, Valerie, Mitra, Diya, Liu, Wei, Zheng, Pingping, Uziel, Tami, Lam, Lloyd, Minden, Mark, Ross, Jeremy, Mendes, Wellington, Potluri, Jalaja, Wei, Andrew, Konopleva, Marina, Dail, Monique, Chyla, Brenda, Epling-Burnette, Pk
Publicado 2023

Decoupling Lineage-Associated Genes in Acute Myeloid Leukemia Reveals Inflammatory and Metabolic Signatures Associated With Outcomes

por Abbas, Hussein A., Mohanty, Vakul, Wang, Ruiping, Huang, Yuefan, Liang, Shaoheng, Wang, Feng, Zhang, Jianhua, Qiu, Yihua, Hu, Chenyue W., Qutub, Amina A., Dail, Monique, Bolen, Christopher R., Daver, Naval, Konopleva, Marina, Futreal, Andrew, Chen, Ken, Wang, Linghua, Kornblau, Steven M.
Publicado 2021

Impact of Venetoclax and Azacitidine in Treatment-Naïve Patients with Acute Myeloid Leukemia and IDH1/2 Mutations

por Pollyea, Daniel A., DiNardo, Courtney D., Arellano, Martha L., Pigneux, Arnaud, Fiedler, Walter, Konopleva, Marina, Rizzieri, David A., Smith, B. Douglas, Shinagawa, Atsushi, Lemoli, Roberto M., Dail, Monique, Duan, Yinghui, Chyla, Brenda, Potluri, Jalaja, Miller, Catherine L., Kantarjian, Hagop M.
Publicado 2022

Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia

por Daver, Naval, Perl, Alexander E., Maly, Joseph, Levis, Mark, Ritchie, Ellen, Litzow, Mark, McCloskey, James, Smith, Catherine C., Schiller, Gary, Bradley, Terrence, Tiu, Ramon V., Naqvi, Kiran, Dail, Monique, Brackman, Deanna, Siddani, Satya, Wang, Jing, Chyla, Brenda, Lee, Paul, Altman, Jessica K.
Publicado 2022

Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine

por Pratz, Keith W., Jonas, Brian A., Pullarkat, Vinod, Recher, Christian, Schuh, Andre C., Thirman, Michael J., Garcia, Jacqueline S., DiNardo, Courtney D., Vorobyev, Vladimir, Fracchiolla, Nicola S., Yeh, Su-Peng, Jang, Jun Ho, Ozcan, Muhit, Yamamoto, Kazuhito, Illes, Arpad, Zhou, Ying, Dail, Monique, Chyla, Brenda, Potluri, Jalaja, Döhner, Hartmut
Publicado 2022

Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

por Kurtova, Antonina V., Heinlein, Melanie, Haas, Simon, Velten, Lars, Dijkgraaf, Gerrit J. P., Storm, Elaine E., Kljavin, Noelyn M., Boumahdi, Soufiane, Himmels, Patricia, Herault, Aurelie, Mancini, Andrew, Koeppen, Hartmut, Dail, Monique, Yan, Qingxiang, Zhang, Jianhuan, Koch, Ute, Radtke, Freddy, Modrusan, Zora, Metcalfe, Ciara, Piskol, Robert, de Sauvage, Frederic J.
Publicado 2022

Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

por Han, Lina, Zhang, Qi, Dail, Monique, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R., Zhao, Yang, Kim, Eugene, Rahmani, Mohamed, Mak, Duncan H., Jin, Sha S., Chen, Jun, Phillips, Darren C., Koller, Paul Bottecelli, Jacamo, Rodrigo, Burks, Jared K., DiNardo, Courtney, Daver, Naval, Jabbour, Elias, Wang, Jing, Kantarjian, Hagop M., Andreeff, Michael, Grant, Steven, Leverson, Joel D., Sampath, Deepak, Konopleva, Marina
Publicado 2020

Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial

por Daver, Naval G., Dail, Monique, Garcia, Jacqueline S., Jonas, Brian A., Yee, Karen W. L., Kelly, Kevin R., Vey, Norbert, Assouline, Sarit, Roboz, Gail J., Paolini, Stefania, Pollyea, Daniel A., Tafuri, Agostino, Brandwein, Joseph M., Pigneux, Arnaud, Powell, Bayard L., Fenaux, Pierre, Olin, Rebecca L., Visani, Giuseppe, Martinelli, Giovanni, Onishi, Maika, Wang, Jue, Huang, Weize, Green, Cherie, Ott, Marion G., Hong, Wan-Jen, Konopleva, Marina Y., Andreeff, Michael
Publicado 2023