Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor

por Piserchio, Andrea, Isiorho, Eta A., Dalby, Kevin N., Ghose, Ranajeet
Publicado 2023

Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers

por Jo, Hyun Hwa, Edupuganti, Ramakrishna, You, Lei, Dalby, Kevin N., Anslyn, Eric V.
Publicado 2015

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

por Wang, Qiantao, Edupuganti, Ramakrishna, Tavares, Clint D. J., Dalby, Kevin N., Ren, Pengyu
Publicado 2015

JNK Signaling in Stem Cell Self-Renewal and Differentiation

por Semba, Takashi, Sammons, Rachel, Wang, Xiaoping, Xie, Xuemei, Dalby, Kevin N., Ueno, Naoto T.
Publicado 2020

A tunable assay for modulators of genome-destabilizing DNA structures

por del Mundo, Imee M A, Cho, Eun Jeong, Dalby, Kevin N, Vasquez, Karen M
Publicado 2019

Identification and Validation of Novel PERK Inhibitors

por Wang, Qiantao, Park, Jihyun, Devkota, Ashwini K., Cho, Eun Jeong, Dalby, Kevin N., Ren, Pengyu
Publicado 2014

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

por Scheele, Remkes A., Lindenburg, Laurens H., Petek, Maya, Schober, Markus, Dalby, Kevin N., Hollfelder, Florian
Publicado 2022

A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach

por Lee, Sunbae, Warthaka, Mangalika, Yan, Chunli, Kaoud, Tamer S., Piserchio, Andrea, Ghose, Ranajeet, Ren, Pengyu, Dalby, Kevin N.
Publicado 2011

The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation

por Coffa, Sergio, Breitman, Maya, Hanson, Susan M., Callaway, Kari, Kook, Seunghyi, Dalby, Kevin N., Gurevich, Vsevolod V.
Publicado 2011

Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2

por Piserchio, Andrea, Ramakrishan, Venkatesh, Wang, Hsin, Kaoud, Tamer S., Arshava, Boris, Dutta, Kaushik, Dalby, Kevin N., Ghose, Ranajeet
Publicado 2015

Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2

por Piserchio, Andrea, Ramakrishan, Venkatesh, Wang, Hsin, Kaoud, Tamer S., Arshava, Boris, Dutta, Kaushik, Dalby, Kevin N., Ghose, Ranajeet
Publicado 2015

ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin

por Piserchio, Andrea, Long, Kimberly J., Browning, Luke S., Bohanon, Amanda L., Isiorho, Eta A., Dalby, Kevin N., Ghose, Ranajeet
Publicado 2023

Modeling Organochlorine Compounds and the σ-Hole Effect Using a Polarizable Multipole Force Field

por Mu, Xiaojiao, Wang, Qiantao, Wang, Lee-Ping, Fried, Stephen D., Piquemal, Jean-Philip, Dalby, Kevin N., Ren, Pengyu
Publicado 2014

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

por Ebelt, Nancy D., Kaoud, Tamer S., Edupuganti, Ramakrishna, Van Ravenstein, Sabrina, Dalby, Kevin N., Van Den Berg, Carla L.
Publicado 2017

High-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2

por Sammons, Rachel M., Bohanon, Amanda L., Kowtha, Anvith, Dejong, Audrey, Cho, Eun Jeong, Kaoud, Tamer S., Dalby, Kevin N.
Publicado 2022

Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase

por Piserchio, Andrea, Isiorho, Eta A., Long, Kimberly, Bohanon, Amanda L., Kumar, Eric A., Will, Nathan, Jeruzalmi, David, Dalby, Kevin N., Ghose, Ranajeet
Publicado 2022

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells

por Perry-Hauser, Nicole A., Kaoud, Tamer S., Stoy, Henriette, Zhan, Xuanzhi, Chen, Qiuyan, Dalby, Kevin N., Iverson, Tina M., Gurevich, Vsevolod V., Gurevich, Eugenia V.
Publicado 2022

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

por Tekedereli, Ibrahim, Alpay, S. Neslihan, Tavares, Clint D. J., Cobanoglu, Zehra E., Kaoud, Tamer S., Sahin, Ibrahim, Sood, Anil K., Lopez-Berestein, Gabriel, Dalby, Kevin N., Ozpolat, Bulent
Publicado 2012

Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA−/lo castration-resista...

por Rycaj, Kiera, Cho, Eun Jeong, Liu, Xin, Chao, Hsueh-Ping, Liu, Bigang, Li, Qiuhui, Devkota, Ashwini K., Zhang, Dingxiao, Chen, Xin, Moore, John, Dalby, Kevin N., Tang, Dean G.
Publicado 2016

Peptide mini-scaffold facilitates JNK3 activation in cells

por Zhan, Xuanzhi, Stoy, Henriette, Kaoud, Tamer S., Perry, Nicole A., Chen, Qiuyan, Perez, Alejandro, Els-Heindl, Sylvia, Slagis, Jack V., Iverson, Tina M., Beck-Sickinger, Annette G., Gurevich, Eugenia V., Dalby, Kevin N., Gurevich, Vsevolod V.
Publicado 2016