Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics

por Yu, Haoran, Dalby, Paul A.
Publicado 2018

Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off

por Yu, Haoran, Dalby, Paul A.
Publicado 2018

Stability enhancement in a mAb and Fab coformulation

por Zhang, Hongyu, Dalby, Paul A.
Publicado 2020

Engineering of enzymes using non-natural amino acids

por Li, Yiwen, Dalby, Paul A.
Publicado 2022

Stability Convergence in Antibody Coformulations

por Zhang, Hongyu, Dalby, Paul A.
Publicado 2022

Directed evolution strategies for improved enzymatic performance

por Hibbert, Edward G, Dalby, Paul A
Publicado 2005

Novel insights into transketolase activation by cofactor binding identifies two native species subpopulations

por Wilkinson, Henry C., Dalby, Paul A.
Publicado 2019

The Two-Species Model of transketolase explains donor substrate-binding, inhibition and heat-activation

por Wilkinson, Henry C., Dalby, Paul A.
Publicado 2020

Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase

por Colin, Pierre-Yves, Dalby, Paul A.
Publicado 2020

Two strategies to engineer flexible loops for improved enzyme thermostability

por Yu, Haoran, Yan, Yihan, Zhang, Cheng, Dalby, Paul A.
Publicado 2017

An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations

por Pandya, Akash, Howard, Mark J., Zloh, Mire, Dalby, Paul A.
Publicado 2018

Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches

por Barata, Teresa S., Zhang, Cheng, Dalby, Paul A., Brocchini, Steve, Zloh, Mire
Publicado 2016

Advancements in the co-formulation of biologic therapeutics

por Chauhan, Veeren M., Zhang, Hongyu, Dalby, Paul A., Aylott, Jonathan W.
Publicado 2020

Machine learning reveals hidden stability code in protein native fluorescence

por Zhang, Hongyu, Yang, Yang, Zhang, Cheng, Farid, Suzanne S., Dalby, Paul A.
Publicado 2021

Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents

por Morris, Phattaraporn, García-Arrazola, Ribia, Rios-Solis, Leonardo, Dalby, Paul A.
Publicado 2021

Optically Induced Thermal Gradients for Protein Characterization in Nanolitre-scale Samples in Microfluidic Devices

por Sagar, D. M., Aoudjane, Samir, Gaudet, Matthieu, Aeppli, Gabriel, Dalby, Paul A.
Publicado 2013

Virus lasers for biological detection

por Hales, John E., Matmon, Guy, Dalby, Paul A., Ward, John M., Aeppli, Gabriel
Publicado 2019

Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration

por Zhang, Cheng, Berg, Adam, Joe, Carina C. D., Dalby, Paul A., Douglas, Alexander D.
Publicado 2023

NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF

por Kellerman, Mark-Adam W., Almeida, Teresa, Rudd, Timothy R., Matejtschuk, Paul, Dalby, Paul A.
Publicado 2022

Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation

por Zhang, Cheng, Codina, Nuria, Tang, Jiazhi, Yu, Haoran, Chakroun, Nesrine, Kozielski, Frank, Dalby, Paul A.
Publicado 2021