Critical Investigation of the Usability of Hepatoma Cell Lines HepG2 and Huh7 as Models for the Metabolic Representation of Resectable Hepatocellular Carcinoma

por Schicht, Gerda, Seidemann, Lena, Haensel, Rene, Seehofer, Daniel, Damm, Georg
Publicado 2022

Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis

por Seidemann, Lena, Krüger, Anne, Kegel-Hübner, Victoria, Seehofer, Daniel, Damm, Georg
Publicado 2021

Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-Matrigel matrices

por Seidemann, Lena, Prinz, Sarah, Scherbel, Jan-Constantin, Götz, Christina, Seehofer, Daniel, Damm, Georg
Publicado 2023

Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence as a Capable Application for Energy Metabolism Experiments in In Vitro Oncologic Liver Mode...

por Scheffschick, Andrea, Babel, Jonas, Sperling, Sebastian, Nerusch, Julia, Herzog, Natalie, Seehofer, Daniel, Damm, Georg
Publicado 2022

Resveratrol Differentially Regulates NAMPT and SIRT1 in Hepatocarcinoma Cells and Primary Human Hepatocytes

por Schuster, Susanne, Penke, Melanie, Gorski, Theresa, Petzold-Quinque, Stefanie, Damm, Georg, Gebhardt, Rolf, Kiess, Wieland, Garten, Antje
Publicado 2014

Prolonged Lipid Accumulation in Cultured Primary Human Hepatocytes Rather Leads to ER Stress than Oxidative Stress

por Rennert, Christiane, Heil, Theresa, Schicht, Gerda, Stilkerich, Anna, Seidemann, Lena, Kegel-Hübner, Victoria, Seehofer, Daniel, Damm, Georg
Publicado 2020

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

por Kegel, Victoria, Pfeiffer, Elisa, Burkhardt, Britta, Liu, Jia L., Zeilinger, Katrin, Nüssler, Andreas K., Seehofer, Daniel, Damm, Georg
Publicado 2015

Effect of glucose and insulin supplementation on the isolation of primary human hepatocytes

por Damm, Georg, Schicht, Gerda, Zimmermann, Andrea, Rennert, Christiane, Fischer, Nicolas, Kießig, Melanie, Wagner, Tristan, Kegel, Victoria, Seehofer, Daniel
Publicado 2019

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

por Freyer, Nora, Knöspel, Fanny, Damm, Georg, Greuel, Selina, Schneider, Christin, Seehofer, Daniel, Stöhr, Thomas, Petersen, Karl-Uwe, Zeilinger, Katrin
Publicado 2019

Imatinib and spironolactone suppress hepcidin expression

por Mleczko-Sanecka, Katarzyna, da Silva, Ana Rita, Call, Debora, Neves, Joana, Schmeer, Nikolai, Damm, Georg, Seehofer, Daniel, Muckenthaler, Martina U.
Publicado 2017

In Vivo and In Vitro Characterization of Primary Human Liver Macrophages and Their Inflammatory State

por Zimmermann, Andrea, Hänsel, René, Gemünden, Kilian, Kegel-Hübner, Victoria, Babel, Jonas, Bläker, Hendrik, Matz-Soja, Madlen, Seehofer, Daniel, Damm, Georg
Publicado 2021

Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor

por Freyer, Nora, Knöspel, Fanny, Strahl, Nadja, Amini, Leila, Schrade, Petra, Bachmann, Sebastian, Damm, Georg, Seehofer, Daniel, Jacobs, Frank, Monshouwer, Mario, Zeilinger, Katrin
Publicado 2016

Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

por Roser, Luise A., Luckhardt, Sonja, Ziegler, Nicole, Thomas, Dominique, Wagner, Pia Viktoria, Damm, Georg, Scheffschick, Andrea, Hewitt, Philip, Parnham, Michael J., Schiffmann, Susanne
Publicado 2023

Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions

por Freyer, Nora, Greuel, Selina, Knöspel, Fanny, Gerstmann, Florian, Storch, Lisa, Damm, Georg, Seehofer, Daniel, Foster Harris, Jennifer, Iyer, Rashi, Schubert, Frank, Zeilinger, Katrin
Publicado 2018

Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity

por Ruoß, Marc, Damm, Georg, Vosough, Massoud, Ehret, Lisa, Grom-Baumgarten, Carl, Petkov, Martin, Naddalin, Silvio, Ladurner, Ruth, Seehofer, Daniel, Nussler, Andreas, Sajadian, Sahar
Publicado 2019

Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma

por Sajadian, Sahar Olsadat, Ehnert, Sabrina, Vakilian, Haghighat, Koutsouraki, Eirini, Damm, Georg, Seehofer, Daniel, Thasler, Wolfgang, Dooley, Steven, Baharvand, Hossein, Sipos, Bence, Nussler, Andreas K.
Publicado 2015

Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects

por Schupp, Thomas, Damm, Georg, Foth, Heidi, Freyberger, Alexius, Gebel, Thomas, Gundert-Remy, Ursula, Hengstler, Jan G., Mangerich, Aswin, Partosch, Falko, Röhl, Claudia, Wollin, Klaus-Michael
Publicado 2020

The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-β(1)-induced cellular damage

por Ehnert, Sabrina, Lukoschek, Teresa, Bachmann, Anastasia, Martínez Sánchez, Juan J, Damm, Georg, Nussler, Natascha C, Pscherer, Stefan, Stöckle, Ulrich, Dooley, Steven, Mueller, Sebastian, Nussler, Andreas K
Publicado 2013

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

por Knöspel, Fanny, Jacobs, Frank, Freyer, Nora, Damm, Georg, De Bondt, An, van den Wyngaert, Ilse, Snoeys, Jan, Monshouwer, Mario, Richter, Marco, Strahl, Nadja, Seehofer, Daniel, Zeilinger, Katrin
Publicado 2016

3D Cultivation Techniques for Primary Human Hepatocytes

por Bachmann, Anastasia, Moll, Matthias, Gottwald, Eric, Nies, Cordula, Zantl, Roman, Wagner, Helga, Burkhardt, Britta, Sánchez, Juan J. Martínez, Ladurner, Ruth, Thasler, Wolfgang, Damm, Georg, Nussler, Andreas K.
Publicado 2015