Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth

por Xue, Yun-Wei, Itoh, Hiroaki, Dan, Shingo, Inoue, Masayuki
Publicado 2022

A novel thiophene‐3‐carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I

por Akatsuka, Akinobu, Kojima, Naoto, Okamura, Mutsumi, Dan, Shingo, Yamori, Takao
Publicado 2016

Suppression of tumor metastasis by a RECK-activating small molecule

por Yoshida, Yoko, Yuki, Kanako, Dan, Shingo, Yamazaki, Kanami, Noda, Makoto
Publicado 2022

Discovery of novel DNA‐damaging agents through phenotypic screening for DNA double‐strand break

por Zhang, Doudou, Shimokawa, Takashi, Guo, Qianqian, Dan, Shingo, Miki, Yoshio, Sunada, Shigeaki
Publicado 2022

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

por Ohta, Kaito, Fushimi, Tetsuya, Okamura, Mutsumi, Akatsuka, Akinobu, Dan, Shingo, Iwasaki, Hiroki, Yamashita, Masayuki, Kojima, Naoto
Publicado 2022

Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis

por Kitajima, Yuya, Ishii, Takuya, Kohda, Takeo, Ishizuka, Masahiro, Yamazaki, Kanami, Nishimura, Yumiko, Tanaka, Tohru, Dan, Shingo, Nakajima, Motowo
Publicado 2019

Cancer immunotherapy with PI3K and PD-1 dual-blockade via optimal modulation of T cell activation signal

por Isoyama, Sho, Mori, Shigeyuki, Sugiyama, Daisuke, Kojima, Yasuhiro, Tada, Yasuko, Shitara, Kohei, Hinohara, Kunihiko, Dan, Shingo, Nishikawa, Hiroyoshi
Publicado 2021

Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors

por Momose, Isao, Abe, Hikaru, Watanabe, Takumi, Ohba, Shun-ichi, Yamazaki, Kanami, Dan, Shingo, Yamori, Takao, Masuda, Tohru, Nomoto, Akio
Publicado 2014

Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting a...

por Hanaki, Yusuke, Kikumori, Masayuki, Tokuda, Harukuni, Okamura, Mutsumi, Dan, Shingo, Adachi, Naoko, Saito, Naoaki, Yanagita, Ryo C., Irie, Kazuhiro
Publicado 2017

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation

por Kunimasa, Kazuhiro, Ikeda-Ishikawa, Chika, Tani, Yuri, Tsukahara, Satomi, Sakurai, Junko, Okamoto, Yuka, Koido, Masaru, Dan, Shingo, Tomida, Akihiro
Publicado 2022

Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors

por Isoyama, Sho, Tamaki, Naomi, Noguchi, Yutaka, Okamura, Mutsumi, Yoshimatsu, Yuki, Kondo, Tadashi, Suzuki, Takeshi, Yaguchi, Shin-ichi, Dan, Shingo
Publicado 2023

AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy

por Ohashi, Yoshimi, Iijima, Hiroshi, Yamaotsu, Noriyuki, Yamazaki, Kanami, Sato, Shigeo, Okamura, Mutsumi, Sugimoto, Kenji, Dan, Shingo, Hirono, Shuichi, Yamori, Takao
Publicado 2012

Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474

por Isoyama, Sho, Kajiwara, Gensei, Tamaki, Naomi, Okamura, Mutsumi, Yoshimi, Hisashi, Nakamura, Naoki, Kawamura, Kento, Nishimura, Yumiko, Namatame, Nachi, Yamori, Takao, Dan, Shingo
Publicado 2015

In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells

por Tang, Sheng-An, Zhou, Qianxiang, Guo, Wen-Zhi, Qiu, Yuling, Wang, Ran, Jin, Meihua, Zhang, Wenjing, Li, Ke, Yamori, Takao, Dan, Shingo, Kong, Dexin
Publicado 2014

Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer

por Suenaga, Mitsukuni, Mashima, Tetsuo, Kawata, Naomi, Wakatsuki, Takeru, Horiike, Yuki, Matsusaka, Satoshi, Dan, Shingo, Shinozaki, Eiji, Seimiya, Hiroyuki, Mizunuma, Nobuyuki, Yamaguchi, Kensei, Yamaguchi, Toshiharu
Publicado 2016

Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines

por Namatame, Nachi, Tamaki, Naomi, Yoshizawa, Yuya, Okamura, Mutsumi, Nishimura, Yumiko, Yamazaki, Kanami, Tanaka, Miwa, Nakamura, Takuro, Semba, Kentaro, Yamori, Takao, Yaguchi, Shin-ichi, Dan, Shingo
Publicado 2018

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

por KAWATANI, MAKOTO, AONO, HARUMI, HIRANUMA, SAYOKO, SHIMIZU, TAKESHI, MUROI, MAKOTO, NOGAWA, TOSHIHIKO, OHISHI, TOMOKAZU, OHBA, SHUN-ICHI, KAWADA, MANABU, YAMAZAKI, KANAMI, DAN, SHINGO, DOHMAE, NAOSHI, OSADA, HIROYUKI
Publicado 2023

Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation

por Mashima, Tetsuo, Ushijima, Masaru, Matsuura, Masaaki, Tsukahara, Satomi, Kunimasa, Kazuhiro, Furuno, Aki, Saito, Sakae, Kitamura, Masami, Soma-Nagae, Taeko, Seimiya, Hiroyuki, Dan, Shingo, Yamori, Takao, Tomida, Akihiro
Publicado 2015

Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors

por Ohashi, Yoshimi, Okamura, Mutsumi, Katayama, Ryohei, Fang, Siyang, Tsutsui, Saki, Akatsuka, Akinobu, Shan, Mingde, Choi, Hyeong-Wook, Fujita, Naoya, Yoshimatsu, Kentaro, Shiina, Isamu, Yamori, Takao, Dan, Shingo
Publicado 2017

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

por Kawasaki, Natsumi, Isogaya, Kazunobu, Dan, Shingo, Yamori, Takao, Takano, Hiroshi, Yao, Ryoji, Morishita, Yasuyuki, Taguchi, Luna, Morikawa, Masato, Heldin, Carl-Henrik, Noda, Tetsuo, Ehata, Shogo, Miyazono, Kohei, Koinuma, Daizo
Publicado 2018