Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes

por Dančík, Vlado, Seiler, Kathleen Petri, Young, Damian W., Schreiber, Stuart L., Clemons, Paul A.
Publicado 2010

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

por Bessen, Jeffrey L., Afeyan, Lena K., Dančík, Vlado, Koblan, Luke W., Thompson, David B., Leichner, Chas, Clemons, Paul A., Liu, David R.
Publicado 2019

Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

por Bessen, Jeffrey L., Afeyan, Lena K., Dančík, Vlado, Koblan, Luke W., Thompson, David B., Leichner, Chas, Clemons, Paul A., Liu, David R.
Publicado 2019

Knowledge Beacons: Web services for data harvesting of distributed biomedical knowledge

por Hannestad, Lance M., Dančík, Vlado, Godden, Meera, Suen, Imelda W., Huellas-Bruskiewicz, Kenneth C., Good, Benjamin M., Mungall, Christopher J., Bruskiewich, Richard M.
Publicado 2021

Predicting compound activity from phenotypic profiles and chemical structures

por Moshkov, Nikita, Becker, Tim, Yang, Kevin, Horvath, Peter, Dancik, Vlado, Wagner, Bridget K., Clemons, Paul A., Singh, Shantanu, Carpenter, Anne E., Caicedo, Juan C.
Publicado 2023

Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity

por Small, Jonnell C., Joblin-Mills, Aidan, Carbone, Kaycee, Kost-Alimova, Maria, Ayukawa, Kumiko, Khodier, Carol, Dancik, Vlado, Clemons, Paul A., Munkacsi, Andrew B., Wagner, Bridget K.
Publicado 2022

Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming

por Choudhary, Amit, Hu He, Kaihui, Mertins, Philipp, Udeshi, Namrata D., Dančík, Vlado, Fomina-Yadlin, Dina, Kubicek, Stefan, Clemons, Paul A., Schreiber, Stuart L., Carr, Steven A., Wagner, Bridget K.
Publicado 2014

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

por Dirice, Ercument, Walpita, Deepika, Vetere, Amedeo, Meier, Bennett C., Kahraman, Sevim, Hu, Jiang, Dančík, Vlado, Burns, Sean M., Gilbert, Tamara J., Olson, David E., Clemons, Paul A., Kulkarni, Rohit N., Wagner, Bridget K.
Publicado 2016

CTD(2) Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network

por Aksoy, Bülent Arman, Dančík, Vlado, Smith, Kenneth, Mazerik, Jessica N., Ji, Zhou, Gross, Benjamin, Nikolova, Olga, Jaber, Nadia, Califano, Andrea, Schreiber, Stuart L., Gerhard, Daniela S., Hermida, Leandro C., Jagu, Subhashini, Sander, Chris, Floratos, Aris, Clemons, Paul A.
Publicado 2017

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

por Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.
Publicado 2019

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

por Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Publicado 2017

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

por Li, Gang, Diogo, Dorothée, Wu, Di, Spoonamore, Jim, Dancik, Vlado, Franke, Lude, Kurreeman, Fina, Rossin, Elizabeth J., Duclos, Grant, Hartland, Cathy, Zhou, Xuezhong, Li, Kejie, Liu, Jun, De Jager, Philip L., Siminovitch, Katherine A., Zhernakova, Alexandra, Raychaudhuri, Soumya, Bowes, John, Eyre, Steve, Padyukov, Leonid, Gregersen, Peter K., Worthington, Jane, Gupta, Namrata, Clemons, Paul A., Stahl, Eli, Tolliday, Nicola, Plenge, Robert M.
Publicado 2013

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

por Rees, Matthew G., Seashore-Ludlow, Brinton, Cheah, Jaime H., Adams, Drew J., Price, Edmund V., Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E., Jones, Victor L., Bodycombe, Nicole E., Soule, Christian K., Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D., Hon, C. Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A., Clish, Clary B., Bittker, Joshua A., Palmer, Michelle, Wagner, Bridget K., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2015

Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science

por Unni, Deepak R., Moxon, Sierra A. T., Bada, Michael, Brush, Matthew, Bruskiewich, Richard, Caufield, J. Harry, Clemons, Paul A., Dancik, Vlado, Dumontier, Michel, Fecho, Karamarie, Glusman, Gustavo, Hadlock, Jennifer J., Harris, Nomi L., Joshi, Arpita, Putman, Tim, Qin, Guangrong, Ramsey, Stephen A., Shefchek, Kent A., Solbrig, Harold, Soman, Karthik, Thessen, Anne E., Haendel, Melissa A., Bizon, Chris, Mungall, Christopher J., Acevedo, Liliana, Ahalt, Stanley C., Alden, John, Alkanaq, Ahmed, Amin, Nada, Avila, Ricardo, Balhoff, Jim, Baranzini, Sergio E., Baumgartner, Andrew, Baumgartner, William, Belhu, Basazin, Brandes, MacKenzie, Brandon, Namdi, Burtt, Noel, Byrd, William, Callaghan, Jackson, Cano, Marco Alvarado, Carrell, Steven, Celebi, Remzi, Champion, James, Chen, Zhehuan, Chen, Mei‐Jan, Chung, Lawrence, Cohen, Kevin, Conlin, Tom, Corkill, Dan, Costanzo, Maria, Cox, Steven, Crouse, Andrew, Crowder, Camerron, Crumbley, Mary E., Dai, Cheng, Dančík, Vlado, De Miranda Azevedo, Ricardo, Deutsch, Eric, Dougherty, Jennifer, Duby, Marc P., Duvvuri, Venkata, Edwards, Stephen, Emonet, Vincent, Fehrmann, Nathaniel, Flannick, Jason, Foksinska, Aleksandra M., Gardner, Vicki, Gatica, Edgar, Glen, Amy, Goel, Prateek, Gormley, Joseph, Greyber, Alon, Haaland, Perry, Hanspers, Kristina, He, Kaiwen, He, Kaiwen, Henrickson, Jeff, Hinderer, Eugene W., Hoatlin, Maureen, Hoffman, Andrew, Huang, Sui, Huang, Conrad, Hubal, Robert, Huellas‐Bruskiewicz, Kenneth, Huls, Forest B., Hunter, Lawrence, Hyde, Greg, Issabekova, Tursynay, Jarrell, Matthew, Jenkins, Lindsay, Johs, Adam, Kang, Jimin, Kanwar, Richa, Kebede, Yaphet, Kim, Keum Joo, Kluge, Alexandria, Knowles, Michael, Koesterer, Ryan, Korn, Daniel, Koslicki, David, Krishnamurthy, Ashok, Kvarfordt, Lindsey, Lee, Jay, Leigh, Margaret, Lin, Jason, Liu, Zheng, Liu, Shaopeng, Ma, Chunyu, Magis, Andrew, Mamidi, Tarun, Mandal, Meisha, Mantilla, Michelle, Massung, Jeffrey, Mauldin, Denise, McClelland, Jason, McMurry, Julie, Mease, Philip, Mendoza, Luis, Mersmann, Marian, Mesbah, Abrar, Might, Matthew, Morton, Kenny, Muller, Sandrine, Muluka, Arun Teja, Osborne, John, Owen, Phil, Patton, Michael, Peden, David B., Peene, R. Carter, Persaud, Bria, Pfaff, Emily, Pico, Alexander, Pollard, Elizabeth, Price, Guthrie, Raj, Shruti, Reilly, Jason, Riutta, Anders, Roach, Jared, Roper, Ryan T., Rosenblatt, Greg, Rubin, Irit, Rucka, Sienna, Rudavsky‐Brody, Nathaniel, Sakaguchi, Rayn, Santos, Eugene, Schaper, Kevin, Schmitt, Charles P., Schurman, Shepherd, Scott, Erik, Seitanakis, Sarah, Sharma, Priya, Shmulevich, Ilya, Shrestha, Manil, Shrivastava, Shalki, Sinha, Meghamala, Smith, Brett, Southall, Noel, Southern, Nicholas, Stillwell, Lisa, Strasser, Michael " Michi", Su, Andrew I., Ta, Casey, Thessen, Anne E., Tinglin, Jillian, Tonstad, Lucas, Tran‐Nguyen, Thi, Tropsha, Alexander, Vaidya, Gaurav, Veenhuis, Luke, Viola, Adam, von Grotthuss, Marcin, Wang, Max, Wang, Patrick, Watkins, Paul B., Weber, Rosina, Wei, Qi, Weng, Chunhua, Whitlock, Jordan, Williams, Mark D., Williams, Andrew, Womack, Finn, Wood, Erica, Wu, Chunlei, Xin, Jiwen Kevin, Xu, Hao, Xu, Colleen, Yakaboski, Chase, Yao, Yao, Yi, Hong, Yilmaz, Arif, Zheng, Marissa, Zhou, Xinghua, Zhou, Eric, Zhu, Qian, Zisk, Tom
Publicado 2022

Progress toward a universal biomedical data translator

por Fecho, Karamarie, Thessen, Anne E., Baranzini, Sergio E., Bizon, Chris, Hadlock, Jennifer J., Huang, Sui, Roper, Ryan T., Southall, Noel, Ta, Casey, Watkins, Paul B., Williams, Mark D., Xu, Hao, Byrd, William, Dančík, Vlado, Duby, Marc P., Dumontier, Michel, Glusman, Gustavo, Harris, Nomi L., Hinderer, Eugene W., Hyde, Greg, Johs, Adam, Su, Andrew I., Qin, Guangrong, Zhu, Qian, Dougherty, Jennifer, Huang, Conrad, Magis, Andrew, Smith, Brett, Celebi, Remzi, Chen, Zhehuan, Azevedo, Ricardo De Miranda, Emonet, Vincent, Lee, Jay, Weng, Chunhua, Yilmaz, Arif, Kim, Keum Joo, Santos, Eugene, Tonstad, Lucas, Veenhuis, Luke, Yakaboski, Chase, Acevedo, Liliana, Carrell, Steven, Deutsch, Eric, Glen, Amy, Hoffman, Andrew, Koslicki, David, Kvarfordt, Lindsey, Liu, Zheng, Liu, Shaopeng, Ma, Chunyu, Mendoza, Luis, Muluka, Arun Teja, Womack, Finn, Wood, Erica, Roach, Jared, Goel, Prateek, Weber, Rosina, Williams, Andrew, Gormley, Joseph, Zisk, Tom, Hanspers, Kristina, Hoatlin, Maureen, Pico, Alexander, Riutta, Anders, Callaghan, Jackson, Xu, Colleen, Ahalt, Stanley C., Balhoff, Jim, Edwards, Stephen, Haaland, Perry, Knowles, Michael, Krishnamurthy, Ashok, Mandal, Meisha, Peden, David B., Pfaff, Emily, Schurman, Shepherd, Shrivastava, Shalki, Yi, Hong, Reilly, Jason, Kanwar, Richa, Cox, Steven, Vaidya, Gaurav, Wang, Max, Alkanaq, Ahmed, Costanzo, Maria, Koesterer, Ryan, Flannick, Jason, Burtt, Noel, Kluge, Alexandria, Rubin, Irit, Strasser, Michael “ Michi”, Chung, Lawrence, Kang, Jimin, Mantilla, Michelle, Muller, Sandrine, Persaud, Bria, Wei, Qi, Baumgartner, Andrew, Dai, Cheng, Duvvuri, Venkata, Mauldin, Denise, Shmulevich, Ilya, Brandon, Namdi, Greyber, Alon, Kebede, Yaphet, Korn, Daniel, Mesbah, Abrar, Owen, Phil, Sakaguchi, Rayn, Seitanakis, Sarah, Tropsha, Alexander, Viola, Adam, Hubal, Robert, Mersmann, Marian, Morton, Kenny, Yao, Yao, Lin, Jason, Avila, Ricardo, Wu, Chunlei, Cano, Marco Alvarado, Gardner, Vicki, Issabekova, Tursynay, McMurry, Julie, Schaper, Kevin, Baumgartner, William, Cohen, Kevin, Gatica, Edgar, Hunter, Lawrence, Price, Guthrie, He, Kaiwen, Henrickson, Jeff, Mamidi, Tarun, Might, Matthew, Osborne, John, Patton, Michael, Rosenblatt, Greg, Tran‐Nguyen, Thi, Crouse, Andrew, Belhu, Basazin, Conlin, Tom, Huellas‐Bruskiewicz, Kenneth, Rudavsky‐Brody, Nathaniel, Shrestha, Manil, Stillwell, Lisa, von Grotthuss, Marcin, Wang, Patrick, Xin, Jiwen Kevin, Zhou, Xinghua, Champion, James, Scott, Erik, Sharma, Priya, Sinha, Meghamala, Raj, Shruti, Mease, Philip, Peene, R. Carter, McClelland, Jason, Schmitt, Charles P., Leigh, Margaret, Corkill, Dan, Zhou, Eric, Alden, John, Massung, Jeffrey, Brandes, Mac Kenzie, Amin, Nada, Chen, Mei‐Jan, Crowder, Camerron, Crumbley, Mary E., Fehrmann, Nathaniel, Foksinska, Aleksandra M., Jenkins, Lindsay, He, Kaiwen, Huls, Forest B., Jarrell, Matthew, Pollard, Elizabeth, Rucka, Sienna, Southern, Nicholas, Tinglin, Jillian, Whitlock, Jordan, Zheng, Marissa
Publicado 2022