P1485: PKM AND PKR EXPRESSION DURING HEMATOPOIESIS AND ERYTHROPOIESIS

por Tsai, Erin, Rivadeneyra, Leonardo, Yilmaz, Saliha, Dang, Lenny, Wind-Rotolo, Megan
Publicado 2023

P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES

por de Wilde, Jonathan, Ruiter, Titine, van Oirschot, Brigitte, Jans, Judith, Dang, Lenny, Wind-Rotolo, Megan, van Solinge, Wouter, van Rhenen, Anna, Van Wijk, Richard, Rab, Minke
Publicado 2023

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice

por Mattè, Alessandro, Kosinski, Penelope A., Federti, Enrica, Dang, Lenny, Recchiuti, Antonio, Russo, Roberta, Siciliano, Angela, Riccardi, Veronica, Janin, Anne, Mucci, Matteo, Leboeuf, Christophe, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia
Publicado 2023

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

por Nottingham, Liesl K., Yan, Carol H., Yang, Xinping, Si, Han, Coupar, Jamie, Bian, Yansong, Cheng, Tsu-Fan, Allen, Clint, Arun, Pattatheyil, Gius, David, Dang, Lenny, Van Waes, Carter, Chen, Zhong
Publicado 2013

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

por Gross, Stefan, Cairns, Rob A., Minden, Mark D., Driggers, Edward M., Bittinger, Mark A., Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P., Su, Shinsan M., Dang, Lenny, Fantin, Valeria R., Mak, Tak W.
Publicado 2010

AG-348 (mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and adenosine triphosphate levels over a broad range...

por Rab, Minke A.E., van Oirschot, Brigitte A., Kosinski, Penelope A., Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, van Straaten, Stephanie, van Solinge, Wouter W., van Beers, Eduard J., Kung, Charles, van Wijk, Richard
Publicado 2020

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

por Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.
Publicado 2019

Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis

por Matte, Alessandro, Wilson, Anand B., Gevi, Federica, Federti, Enrica, Recchiuti, Antonio, Ferri, Giulia, Brunati, Anna Maria, Pagano, Mario Angelo, Russo, Roberta, Leboeuf, Christophe, Janin, Anne, Timperio, Anna Maria, Iolascon, Achille, Gremese, Elisa, Dang, Lenny, Mohandas, Narla, Brugnara, Carlo, De Franceschi, Lucia
Publicado 2023

Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma

por Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K., Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M., Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K., Biller, Scott A.
Publicado 2020

A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model

por Wang, Fang, Travins, Jeremy, Lin, Zhizhong, Si, Yaguang, Chen, Yue, Powe, Josh, Murray, Stuart, Zhu, Dongwei, Artin, Erin, Gross, Stefan, Santiago, Stephanie, Steadman, Mya, Kernytsky, Andrew, Straley, Kimberly, Lu, Chenming, Pop, Ana, Struys, Eduard A., Jansen, Erwin E. W., Salomons, Gajja S., David, Muriel D., Quivoron, Cyril, Penard-Lacronique, Virginie, Regan, Karen S., Liu, Wei, Dang, Lenny, Yang, Hua, Silverman, Lee, Agresta, Samuel, Dorsch, Marion, Biller, Scott, Yen, Katharine, Cang, Yong, Su, Shin-San Michael, Jin, Shengfang
Publicado 2016

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

por Popovici-Muller, Janeta, Lemieux, René M., Artin, Erin, Saunders, Jeffrey O., Salituro, Francesco G., Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D., Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M., Yen, Katharine
Publicado 2018

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

por Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J., Jiang, Jian-kang, Boxer, Matthew B., Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R., Metallo, Christian M., Fiske, Brian P., Courtney, Kevin D., Malstrom, Scott, Khan, Tahsin M., Kung, Charles, Skoumbourdis, Amanda P., Veith, Henrike, Southall, Noel, Walsh, Martin J., Brimacombe, Kyle R., Leister, William, Lunt, Sophia Y., Johnson, Zachary R., Yen, Katharine E., Kunii, Kaiko, Davidson, Shawn M., Christofk, Heather R., Austin, Christopher P., Inglese, James, Harris, Marian H., Asara, John M., Stephanopoulos, Gregory, Salituro, Francesco G., Jin, Shengfang, Dang, Lenny, Auld, Douglas S., Park, Hee-Won, Cantley, Lewis C., Thomas, Craig J., Vander Heiden, Matthew G.
Publicado 2012