Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models

por Danhof, Meindert
Publicado 2015

The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments

por Sahota, Tarjinder, Danhof, Meindert, Della Pasqua, Oscar
Publicado 2015

Characterizing QT interval prolongation in early clinical development: a case study with methadone

por Dubois, Vincent F. S., Danhof, Meindert, Della Pasqua, Oscar
Publicado 2017

Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat

por Geldof, Marian, Freijer, Jan, van Beijsterveldt, Ludy, Danhof, Meindert
Publicado 2007

Pharmacokinetic–Pharmacodynamic Modeling of the Effectiveness and Safety of Buprenorphine and Fentanyl in Rats

por Yassen, Ashraf, Olofsen, Erik, Kan, Jingmin, Dahan, Albert, Danhof, Meindert
Publicado 2007

Extensions to the Visual Predictive Check to facilitate model performance evaluation

por Post, Teun M., Freijer, Jan I., Ploeger, Bart A., Danhof, Meindert
Publicado 2008

The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid

por Westerhout, Joost, Smeets, Jean, Danhof, Meindert, de Lange, Elizabeth C. M.
Publicado 2013

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

por Strougo, Ashley, Eissing, Thomas, Yassen, Ashraf, Willmann, Stefan, Danhof, Meindert, Freijer, Jan
Publicado 2012

Coping with time scales in disease systems analysis: application to bone remodeling

por Schmidt, Stephan, Post, Teun M., Peletier, Lambertus A., Boroujerdi, Massoud A., Danhof, Meindert
Publicado 2011

Application of the Convection–Dispersion Equation to Modelling Oral Drug Absorption

por Freijer, Jan I., Post, Teun M., Ploeger, Bart A., DeJongh, Joost, Danhof, Meindert
Publicado 2006

A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs

por Stevens, Jasper, Suidgeest, Ernst, van der Graaf, Piet Hein, Danhof, Meindert, de Lange, Elizabeth C. M.
Publicado 2009

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

por Ravenstijn, Paulien GM, Drenth, Henk-Jan, O'Neill, Michael J, Danhof, Meindert, de Lange, Elizabeth CM
Publicado 2012

Systematic Evaluation of the Descriptive and Predictive Performance of Paediatric Morphine Population Models

por Krekels, Elke H. J., van Hasselt, Johan G. C., Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Publicado 2010

Summary data of potency and parameter information from semi-mechanistic PKPD modeling of prolactin release following administration of the dopamine D(2) receptor antagonists risper...

por Taneja, Amit, Vermeulen, An, Huntjens, Dymphy R.H., Danhof, Meindert, De Lange, Elizabeth C.M., Proost, Johannes H.
Publicado 2016

Modeling of prolactin response following dopamine D(2) receptor antagonists in rats: can it be translated to clinical dosing?

por Taneja, Amit, Vermeulen, An, Huntjens, Dymphy R. H., Danhof, Meindert, De Lange, Elizabeth C. M., Proost, Johannes H.
Publicado 2017

Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design

por Bender, Gregor, Gosset, James, Florian, Jeff, Tan, Keith, Field, Mark, Marshall, Scott, DeJongh, Joost, Bies, Robert, Danhof, Meindert
Publicado 2009

The role of population PK–PD modelling in paediatric clinical research

por De Cock, Roosmarijn F. W., Piana, Chiara, Krekels, Elke H. J., Danhof, Meindert, Allegaert, Karel, Knibbe, Catherijne A. J.
Publicado 2010

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants

por Krekels, Elke H. J., van Ham, Saskia, Allegaert, Karel, de Hoon, Jan, Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Publicado 2015

Model-Based Optimisation of Deferoxamine Chelation Therapy

por Bellanti, Francesco, Del Vecchio, Giovanni C., Putti, Maria C., Cosmi, Carlo, Fotzi, Ilaria, Bakshi, Suruchi D., Danhof, Meindert, Della Pasqua, Oscar
Publicado 2015

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

por de Witte, Wilhelmus E. A., Rottschäfer, Vivi, Danhof, Meindert, van der Graaf, Piet H., Peletier, Lambertus A., de Lange, Elizabeth C. M.
Publicado 2018