Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

por Darwesh, Ahmed M., Bassiouni, Wesam, Sosnowski, Deanna K., Seubert, John M.
Publicado 2021

Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation

por Darwesh, Ahmed M., Keshavarz-Bahaghighat, Hedieh, Jamieson, K. Lockhart, Seubert, John M.
Publicado 2019

Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids

por Keshavarz-Bahaghighat, Hedieh, Darwesh, Ahmed M., Sosnowski, Deanna K., Seubert, John M.
Publicado 2020

Age and Sex Differences in Hearts of Soluble Epoxide Hydrolase Null Mice

por Jamieson, K. Lockhart, Keshavarz-Bahaghighat, Hedieh, Darwesh, Ahmed M., Sosnowski, Deanna K., Seubert, John M.
Publicado 2020

A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway

por Darwesh, Ahmed M., Bassiouni, Wesam, Adebesin, Adeniyi Michael, Mohammad, Abdul Sattar, Falck, John R., Seubert, John M.
Publicado 2020

Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function

por Zhabyeyev, Pavel, McLean, Brent, Bassiouni, Wesam, Valencia, Robert, Paul, Manish, Darwesh, Ahmed M., Seubert, John M., Hazra, Saugata, Oudit, Gavin Y.
Publicado 2023

Insulin directly stimulates mitochondrial glucose oxidation in the heart

por Karwi, Qutuba G., Wagg, Cory S., Altamimi, Tariq R., Uddin, Golam M., Ho, Kim L., Darwesh, Ahmed M., Seubert, John M., Lopaschuk, Gary D.
Publicado 2020

Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation

por Samokhvalov, Victor, Jamieson, K. Lockhart, Darwesh, Ahmed M., Keshavarz-Bahaghighat, Hedieh, Lee, Tim Y. T., Edin, Matthew, Lih, Fred, Zeldin, Darryl C., Seubert, John M.
Publicado 2019

DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile

por Endo, Tomoko, Samokhvalov, Victor, Darwesh, Ahmed M., Khey, Kevin M. W., El-Sherbeni, Ahmed A., El-Kadi, Ayman O. S., Machida, Takuji, Hirafuji, Masahiko, Seubert, John M.
Publicado 2018

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

por Sosnowski, Deanna K., Jamieson, K. Lockhart, Darwesh, Ahmed M., Zhang, Hao, Keshavarz-Bahaghighat, Hedieh, Valencia, Robert, Viveiros, Anissa, Edin, Matthew L., Zeldin, Darryl C., Oudit, Gavin Y., Seubert, John M.
Publicado 2022

Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury

por Jamieson, K. Lockhart, Darwesh, Ahmed M., Sosnowski, Deanna K., Zhang, Hao, Shah, Saumya, Zhabyeyev, Pavel, Yang, Jun, Hammock, Bruce D., Edin, Matthew L., Zeldin, Darryl C., Oudit, Gavin Y., Kassiri, Zamaneh, Seubert, John M.
Publicado 2021

Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin

por Philippaert, Koenraad, Kalyaanamoorthy, Subha, Fatehi, Mohammad, Long, Wentong, Soni, Shubham, Byrne, Nikole J., Barr, Amy, Singh, Jyoti, Wong, Jordan, Palechuk, Taylor, Schneider, Chloe, Darwesh, Ahmed M., Maayah, Zaid H., Seubert, John M., Barakat, Khaled, Dyck, Jason R.B., Light, Peter E.
Publicado 2021

Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis

por Gopal, Keshav, Abdualkader, Abdualrahman Mohammed, Li, Xiaobei, Greenwell, Amanda A., Karwi, Qutuba G., Altamimi, Tariq R., Saed, Christina, Uddin, Golam M., Darwesh, Ahmed M., Jamieson, K. Lockhart, Kim, Ryekjang, Eaton, Farah, Seubert, John M., Lopaschuk, Gary D., Ussher, John R., Al Batran, Rami
Publicado 2023