A latent variable approach to account for correlated inputs in global sensitivity analysis

por Melillo, Nicola, Darwich, Adam S.
Publicado 2021

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

por Takita, Hiroyuki, Darwich, Adam S., Ahmad, Amais, Rostami‐Hodjegan, Amin
Publicado 2020

Investigating the Connections Between Delivery of Care, Reablement, Workload, and Organizational Factors in Home Care Services: Mixed Methods Study

por Darwich, Adam S, Boström, Anne-Marie, Guidetti, Susanne, Raghothama, Jayanth, Meijer, Sebastiaan
Publicado 2023

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

por Margolskee, Alison, Darwich, Adam S., Galetin, Aleksandra, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado 2015

A novel analytical framework for risk stratification of real‐world data using machine learning: A small cell lung cancer study

por Marzano, Luca, Darwich, Adam S., Tendler, Salomon, Dan, Asaf, Lewensohn, Rolf, De Petris, Luigi, Raghothama, Jayanth, Meijer, Sebastiaan
Publicado 2022

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

por El-Khateeb, Eman, Chinnadurai, Rajkumar, Al Qassabi, Jokha, Scotcher, Daniel, Darwich, Adam S., Kalra, Philip A., Rostami-Hodjegan, Amin
Publicado 2023

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

por Scotcher, Daniel, Melillo, Nicola, Tadimalla, Sirisha, Darwich, Adam S., Ziemian, Sabina, Ogungbenro, Kayode, Schütz, Gunnar, Sourbron, Steven, Galetin, Aleksandra
Publicado 2021

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

por Brill, Margreke J., van Rongen, Anne, van Dongen, Eric P., van Ramshorst, Bert, Hazebroek, Eric J., Darwich, Adam S., Rostami-Hodjegan, Amin, Knibbe, Catherijne A.
Publicado 2015

α-Synuclein pathology spread through the brain connectome is modulated by selective vulnerability and predicted by network analysis

por Henderson, Michael X., Cornblath, Eli J., Darwich, Adam, Zhang, Bin, Brown, Hannah, Gathagan, Ronald J., Sandler, Raizel M., Bassett, Danielle S., Trojanowski, John Q., Lee, Virginia M.Y.
Publicado 2019

Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

por McAllister, Mark, Flanagan, Talia, Cole, Susan, Abend, Andreas, Kotzagiorgis, Evangelos, Limberg, Jobst, Mead, Heather, Mangas-Sanjuan, Victor, Dickinson, Paul A., Moir, Andrea, Pepin, Xavier, Zhou, Diansong, Tistaert, Christophe, Dokoumetzidis, Aristides, Anand, Om, Le Merdy, Maxime, Turner, David B., Griffin, Brendan T., Darwich, Adam, Dressman, Jennifer, Mackie, Claire
Publicado 2022