Pan‐cancer population pharmacokinetics and exposure‐safety and ‐efficacy analyses of atezolizumab in patients with high tumor mutational burden

por Shemesh, Colby S., Chan, Phyllis, Legrand, Fatema A., Shames, David S., Das Thakur, Meghna, Shi, Jane, Bailey, Lorna, Vadhavkar, Shweta, He, Xian, Zhang, Wei, Bruno, René
Publicado 2020

Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic biological processes and a disease specific role for granzyme B

por Daemen, Anneleen, Udyavar, Akshata R., Sandmann, Thomas, Li, Congfen, Bosch, Linda J. W., O’Gorman, William, Li, Yijin, Au-Yeung, Amelia, Takahashi, Chikara, Kabbarah, Omar, Bourgon, Richard, Hegde, Priti, Bais, Carlos, Das Thakur, Meghna
Publicado 2021

Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in KRAS-mutated non-small cell lung cancer with STK11, KEAP1, or TP53 comutations: subgroup results from the pha...

por West, Howard Jack, McCleland, Mark, Cappuzzo, Federico, Reck, Martin, Mok, Tony SK, Jotte, Robert M, Nishio, Makoto, Kim, Eugene, Morris, Stefanie, Zou, Wei, Shames, David, Das Thakur, Meghna, Shankar, Geetha, Socinski, Mark A
Publicado 2022

Tumor Fraction Correlates With Detection of Actionable Variants Across > 23,000 Circulating Tumor DNA Samples

por Husain, Hatim, Pavlick, Dean C., Fendler, Bernard J., Madison, Russell W., Decker, Brennan, Gjoerup, Ole, Parachoniak, Christine A., McLaughlin-Drubin, Molly, Erlich, Rachel L., Schrock, Alexa B., Frampton, Garrett M., Das Thakur, Meghna, Oxnard, Geoffrey R., Tukachinsky, Hanna
Publicado 2022

Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III I...

por Zhou, Caicun, Srivastava, Minu K, Xu, Hao, Felip, Enriqueta, Wakelee, Heather, Altorki, Nasser, Reck, Martin, Liersch, Rüdiger, Kryzhanivska, Anna, Oizumi, Satoshi, Tanaka, Hiroshi, Hamm, John, McCune, Steven L, Bennett, Elizabeth, Gitlitz, Barbara, McNally, Virginia, Ballinger, Marcus, McCleland, Mark, Zou, Wei, Das Thakur, Meghna, Novello, Silvia
Publicado 2023

Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

por Wang, Peiyin, Sun, Liping L., Clark, Robyn, Hristopoulos, Maria, Chiu, Cecilia P.C., Dillon, Michael, Lin, WeiYu, Lo, Amy A., Chalsani, Sreedevi, Das Thakur, Meghna, Zimmerman Savill, Kristin M., Rougé, Lionel, Lupardus, Patrick, Piskol, Robert, Husain, Bushra, Ellerman, Diego, Shivva, Vittal, Leong, Steven R., Ovacik, Meric, Totpal, Klara, Wu, Yan, Spiess, Christoph, Lee, Genee, Leipold, Douglas D., Polson, Andrew G.
Publicado 2022

Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition

por Sundar, Raghav, Huang, Kie-Kyon, Kumar, Vikrant, Ramnarayanan, Kalpana, Demircioglu, Deniz, Her, Zhisheng, Ong, Xuewen, Bin Adam Isa, Zul Fazreen, Xing, Manjie, Tan, Angie Lay-Keng, Tai, David Wai Meng, Choo, Su Pin, Zhai, Weiwei, Lim, Jia Qi, Das Thakur, Meghna, Molinero, Luciana, Cha, Edward, Fasso, Marcella, Niger, Monica, Pietrantonio, Filippo, Lee, Jeeyun, Jeyasekharan, Anand D, Qamra, Aditi, Patnala, Radhika, Fabritius, Arne, De Simone, Mark, Yeong, Joe, Ng, Cedric Chuan Young, Rha, Sun Young, Narita, Yukiya, Muro, Kei, Guo, Yu Amanda, Skanderup, Anders Jacobsen, So, Jimmy Bok Yan, Yong, Wei Peng, Chen, Qingfeng, Göke, Jonathan, Tan, Patrick
Publicado 2022