A blast from the past: ROS1 on the brain

por Odintsov, Igor, Somwar, Romel, Davare, Monika A.
Publicado 2019

Revisiting NTRKs as an emerging oncogene in hematological malignancies

por Joshi, Sunil K., Davare, Monika A., Druker, Brian J., Tognon, Cristina E.
Publicado 2019

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

por Iyer, Sudarshan R, Nusser, Kevin, Jones, Kristen, Shinde, Pushkar, Keddy, Clare, Beach, Catherine Z, Aguero, Erin, Force, Jeremy, Shinde, Ujwal, Davare, Monika A
Publicado 2023

Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma

por Siegel, Matthew B., Liu, Selina Qiuying, Davare, Monika A., Spurgeon, Stephen E., Loriaux, Marc M., Druker, Brian J., Scott, Emma C., Tyner, Jeffrey W.
Publicado 2015

Discovery and Validation of a Compound to Target Ewing’s Sarcoma

por Esfandiari Nazzaro, Ellie, Sabei, Fahad Y., Vogel, Walter K., Nazari, Mohamad, Nicholson, Katelyn S., Gafken, Philip R., Taratula, Olena, Taratula, Oleh, Davare, Monika A., Leid, Mark
Publicado 2021

Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation

por Choo, Florence, Odinstov, Igor, Nusser, Kevin, Nicholson, Katelyn S., Davis, Lara, Corless, Christopher L., Stork, Linda, Somwar, Romel, Ladanyi, Marc, Davis, Jessica L., Davare, Monika A.
Publicado 2022

Activity of Type II RAF Inhibitor Tovorafenib in a Pediatric Patient With a Recurrent Spindle Cell Sarcoma Harboring a Novel SNX8-BRAF Gene Fusion

por Offer, Katharine, McGuire, Michael T., Song, Kunchang, Goldfischer, Michael J., Davare, Monika A., Corless, Christopher L., Beadling, Carol, Neff, Tanaya, Cox, Michael C., Govinda Raju, Sandya, Blackman, Samuel C.
Publicado 2023

Discovery and functional characterization of the oncogenicity and targetability of a novel NOTCH1–ROS1 gene fusion in pediatric angiosarcoma

por Jain, Payal, Iyer, Sudarshan, Straka, Joshua, Surrey, Lea F., Pogoriler, Jennifer, Han, Harry, Smith, Tiffany, Busch, Christine, Fox, Elizabeth, Li, Marilyn, Waanders, Angela J., Resnick, Adam, Davare, Monika A.
Publicado 2022

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3 mutation-positive leukemia

por Agarwal, Anupriya, MacKenzie, Ryan J., Eide, Christopher A., Davare, Monika A., Watanabe-Smith, Kevin, Tognon, Cristina E., Mongoue-Tchokote, Solange, Park, Byung, Braziel, Rita M., Tyner, Jeffrey W., Druker, Brian J.
Publicado 2014

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

por Somwar, Romel, Hofmann, Nicolle E., Smith, Bryan, Odintsov, Igor, Vojnic, Morana, Linkov, Irina, Tam, Ashley, Khodos, Inna, Mattar, Marissa S., de Stanchina, Elisa, Flynn, Daniel, Ladanyi, Marc, Drilon, Alexander, Shinde, Ujwal, Davare, Monika A.
Publicado 2020

Mechanisms of targeted therapy resistance in a pediatric glioma driven by ETV6-NTRK3 fusion

por Keddy, Clare, Neff, Tanaya, Huan, Jianya, Nickerson, Joshua P., Beach, Catherine Z., Akkari, Yassmine, Ji, Jianling, Moore, Stephen, Nazemi, Kellie J., Corless, Christopher L., Beadling, Carol, Woltjer, Randy, Cho, Yoon-Jae, Wood, Matthew D., Davare, Monika A.
Publicado 2021

RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals a role for MYC upregulation

por Hayashi, Takuo, Odintsov, Igor, Smith, Roger S., Ishizawa, Kota, Liu, Allan J. W., Delasos, Lukas, Kurzatkowski, Christopher, Tai, Huichun, Gladstone, Eric, Vojnic, Morana, Kohsaka, Shinji, Suzawa, Ken, Liu, Zebing, Kunte, Siddharth, Mattar, Marissa S., Khodos, Inna, Davare, Monika A., Drilon, Alexander, Cheng, Emily, de Stanchina, Elisa, Ladanyi, Marc, Somwar, Romel
Publicado 2021

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma

por Svalina, Matthew N., Kikuchi, Ken, Abraham, Jinu, Lal, Sangeet, Davare, Monika A., Settelmeyer, Teagan P., Young, Michael C., Peckham, Jennifer L., Cho, Yoon-Jae, Michalek, Joel E., Hernandez, Brian S., Berlow, Noah E., Jackson, Melanie, Guillaume, Daniel J., Selden, Nathan R., Bigner, Darell D., Nazemi, Kellie J., Green, Sarah C., Corless, Christopher L., Gultekin, Sakir, Mansoor, Atiya, Rubin, Brian P., Woltjer, Randall, Keller, Charles
Publicado 2016

NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations

por Drilon, Alexander, Horan, Joshua C., Tangpeerachaikul, Anupong, Besse, Benjamin, Ou, Sai-Hong Ignatius, Gadgeel, Shirish M., Camidge, D. Ross, van der Wekken, Anthonie J., Nguyen-Phuong, Linh, Acker, Adam, Keddy, Clare, Nicholson, Katelyn S., Yoda, Satoshi, Mente, Scot, Sun, Yuting, Soglia, John R., Kohl, Nancy E., Porter, James R., Shair, Matthew D., Zhu, Viola, Davare, Monika A., Hata, Aaron N., Pelish, Henry E., Lin, Jessica J.
Publicado 2023

Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

por Miyazaki, Isao, Odintsov, Igor, Ishida, Keiji, Lui, Allan J. W., Kato, Masanori, Suzuki, Tatsuya, Zhang, Tom, Wakayama, Kentaro, Kurth, Renate I., Cheng, Ryan, Fujita, Hidenori, Delasos, Lukas, Vojnic, Morana, Khodos, Inna, Yamada, Yukari, Ishizawa, Kota, Mattar, Marissa S., Funabashi, Kaoru, Chang, Qing, Ohkubo, Shuichi, Yano, Wakako, Terada, Ryuichiro, Giuliano, Claudio, Lu, Yue Christine, Bonifacio, Annalisa, Kunte, Siddharth, Davare, Monika A., Cheng, Emily H., de Stanchina, Elisa, Lovati, Emanuela, Iwasawa, Yoshikazu, Ladanyi, Marc, Somwar, Romel
Publicado 2023

Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

por Miyazaki, Isao, Odintsov, Igor, Ishida, Keiji, Lui, Allan J. W., Kato, Masanori, Suzuki, Tatsuya, Zhang, Tom, Wakayama, Kentaro, Kurth, Renate I., Cheng, Ryan, Fujita, Hidenori, Delasos, Lukas, Vojnic, Morana, Khodos, Inna, Yamada, Yukari, Ishizawa, Kota, Mattar, Marissa S., Funabashi, Kaoru, Chang, Qing, Ohkubo, Shuichi, Yano, Wakako, Terada, Ryuichiro, Giuliano, Claudio, Lu, Yue Christine, Bonifacio, Annalisa, Kunte, Siddharth, Davare, Monika A., Cheng, Emily H., de Stanchina, Elisa, Lovati, Emanuela, Iwasawa, Yoshikazu, Ladanyi, Marc, Somwar, Romel
Publicado 2023