Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C

por Oudelaar, A. Marieke, Davies, James O.J., Downes, Damien J., Higgs, Douglas R., Hughes, Jim R.
Publicado 2017

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF

por Aljahani, Abrar, Hua, Peng, Karpinska, Magdalena A., Quililan, Kimberly, Davies, James O. J., Oudelaar, A. Marieke
Publicado 2022

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

por Davies, James O.J., Telenius, Jelena M., McGowan, Simon, Roberts, Nigel A., Taylor, Stephen, Higgs, Douglas R., Hughes, Jim R.
Publicado 2015

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

por Godfrey, Laura, Kerry, Jon, Thorne, Ross, Repapi, Emmanouela, Davies, James O.J., Tapia, Marta, Ballabio, Erica, Hughes, Jim R., Geng, Huimin, Konopleva, Marina, Milne, Thomas A.
Publicado 2017

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

por Huang, Peng, Keller, Cheryl A., Giardine, Belinda, Grevet, Jeremy D., Davies, James O.J., Hughes, Jim R., Kurita, Ryo, Nakamura, Yukio, Hardison, Ross C., Blobel, Gerd A.
Publicado 2017

BET inhibition disrupts transcription but retains enhancer-promoter contact

por Crump, Nicholas T., Ballabio, Erica, Godfrey, Laura, Thorne, Ross, Repapi, Emmanouela, Kerry, Jon, Tapia, Marta, Hua, Peng, Lagerholm, Christoffer, Filippakopoulos, Panagis, Davies, James O. J., Milne, Thomas A.
Publicado 2021

Capture-C: A modular and flexible approach for high-resolution chromosome conformation capture

por Downes, Damien J., Smith, Alastair L., Karpinska, Magdalena A., Velychko, Taras, Rue-Albrecht, Kevin, Sims, David, Milne, Thomas A., Davies, James O.J., Oudelaar, A. Marieke, Hughes, Jim R.
Publicado 2022

Direct correction of haemoglobin E β-thalassaemia using base editors

por Badat, Mohsin, Ejaz, Ayesha, Hua, Peng, Rice, Siobhan, Zhang, Weijiao, Hentges, Lance D., Fisher, Christopher A., Denny, Nicholas, Schwessinger, Ron, Yasara, Nirmani, Roy, Noemi B. A., Issa, Fadi, Roy, Andi, Telfer, Paul, Hughes, Jim, Mettananda, Sachith, Higgs, Douglas R., Davies, James O. J.
Publicado 2023

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

por Oudelaar, A. Marieke, Davies, James O.J., Hanssen, Lars L.P., Telenius, Jelena M., Schwessinger, Ron, Liu, Yu, Brown, Jill M., Downes, Damien J., Chiariello, Andrea M., Bianco, Simona, Nicodemi, Mario, Buckle, Veronica J., Dekker, Job, Higgs, Douglas R., Hughes, Jim R.
Publicado 2018

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

por Downes, Damien J., Beagrie, Robert A., Gosden, Matthew E., Telenius, Jelena, Carpenter, Stephanie J., Nussbaum, Lea, De Ornellas, Sara, Sergeant, Martin, Eijsbouts, Chris Q., Schwessinger, Ron, Kerry, Jon, Roberts, Nigel, Shivalingam, Arun, El-Sagheer, Afaf, Oudelaar, A. Marieke, Brown, Tom, Buckle, Veronica J., Davies, James O. J., Hughes, Jim R.
Publicado 2021

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

por Downes, Damien J., Cross, Amy R., Hua, Peng, Roberts, Nigel, Schwessinger, Ron, Cutler, Antony J., Munis, Altar M., Brown, Jill, Mielczarek, Olga, de Andrea, Carlos E., Melero, Ignacio, Gill, Deborah R., Hyde, Stephen C., Knight, Julian C., Todd, John A., Sansom, Stephen N., Issa, Fadi, Davies, James O.J., Hughes, Jim R.
Publicado 2021

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

por Long, Hannah K., Osterwalder, Marco, Welsh, Ian C., Hansen, Karissa, Davies, James O.J., Liu, Yiran E., Koska, Mervenaz, Adams, Alexander T., Aho, Robert, Arora, Neha, Ikeda, Kazuya, Williams, Ruth M., Sauka-Spengler, Tatjana, Porteus, Matthew H., Mohun, Tim, Dickel, Diane E., Swigut, Tomek, Hughes, Jim R., Higgs, Douglas R., Visel, Axel, Selleri, Licia, Wysocka, Joanna
Publicado 2020

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

por Crump, Nicholas T., Smith, Alastair L., Godfrey, Laura, Dopico-Fernandez, Ana M., Denny, Nicholas, Harman, Joe R., Hamley, Joseph C., Jackson, Nicole E., Chahrour, Catherine, Riva, Simone, Rice, Siobhan, Kim, Jaehoon, Basrur, Venkatesha, Fermin, Damian, Elenitoba-Johnson, Kojo, Roeder, Robert G., Allis, C. David, Roberts, Irene, Roy, Anindita, Geng, Huimin, Davies, James O. J., Milne, Thomas A.
Publicado 2023

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

por Yan, TingDong, Ooi, Wen Fong, Qamra, Aditi, Cheung, Alice, Ma, DongLiang, Sundaram, Gopinath Meenakshi, Xu, Chang, Xing, Manjie, Poon, LaiFong, Wang, Jing, Loh, Yan Ping, Ho, Jess Hui Jie, Ng, Joscelyn Jun Quan, Ramlee, Muhammad Khairul, Aswad, Luay, Rozen, Steve G., Ghosh, Sujoy, Bard, Frederic A., Sampath, Prabha, Tergaonkar, Vinay, Davies, James O. J., Hughes, Jim R., Goh, Eyleen, Bi, Xuezhi, Fullwood, Melissa Jane, Tan, Patrick, Li, Shang
Publicado 2018

Reactivation of a developmentally silenced embryonic globin gene

por King, Andrew J., Songdej, Duantida, Downes, Damien J., Beagrie, Robert A., Liu, Siyu, Buckley, Megan, Hua, Peng, Suciu, Maria C., Marieke Oudelaar, A., Hanssen, Lars L. P., Jeziorska, Danuta, Roberts, Nigel, Carpenter, Stephanie J., Francis, Helena, Telenius, Jelena, Olijnik, Aude-Anais, Sharpe, Jacqueline A., Sloane-Stanley, Jacqueline, Eglinton, Jennifer, Kassouf, Mira T., Orkin, Stuart H., Pennacchio, Len A., Davies, James O. J., Hughes, Jim R., Higgs, Douglas R., Babbs, Christian
Publicado 2021

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

por Ooi, Wen Fong, Xing, Manjie, Xu, Chang, Yao, Xiaosai, Ramlee, Muhammad Khairul, Lim, Mei Chee, Cao, Fan, Lim, Kevin, Babu, Deepak, Poon, Lai-Fong, Lin Suling, Joyce, Qamra, Aditi, Irwanto, Astrid, Qu Zhengzhong, James, Nandi, Tannistha, Lee-Lim, Ai Ping, Chan, Yang Sun, Tay, Su Ting, Lee, Ming Hui, Davies, James O. J., Wong, Wai Keong, Soo, Khee Chee, Chan, Weng Hoong, Ong, Hock Soo, Chow, Pierce, Wong, Chow Yin, Rha, Sun Young, Liu, Jianjun, Hillmer, Axel M., Hughes, Jim R., Rozen, Steve, Teh, Bin Tean, Fullwood, Melissa Jane, Li, Shang, Tan, Patrick
Publicado 2016