Quantitative phenotypic and pathway profiling guides rational drug combination strategies

por Dawson, John C., Carragher, Neil O.
Publicado 2014

Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types

por Warchal, Scott J., Dawson, John C., Carragher, Neil O.
Publicado 2016

Ovarian cancer cell lines derived from non-serous carcinomas migrate and invade more aggressively than those derived from high-grade serous carcinomas

por Hallas-Potts, Amelia, Dawson, John C., Herrington, C. Simon
Publicado 2019

Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines

por Warchal, Scott J., Dawson, John C., Carragher, Neil O.
Publicado 2019

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells

por Dawson, John C., Timpson, Paul, Kalna, Gabriela, Machesky, Laura M.
Publicado 2011

Mtss1 Promotes Cell-Cell Junction Assembly and Stability through the Small GTPase Rac1

por Dawson, John C., Bruche, Susann, Spence, Heather J., Braga, Vania M. M., Machesky, Laura M.
Publicado 2012

A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes

por Miskinyte, Migla, Dawson, John C., Makda, Ashraff, Doughty-Shenton, Dahlia, Carragher, Neil O., Schnaufer, Achim
Publicado 2022

Phenonaut: multiomics data integration for phenotypic space exploration

por Shave, Steven, Dawson, John C, Athar, Abdullah M, Nguyen, Cuong Q, Kasprowicz, Richard, Carragher, Neil O
Publicado 2023

Development of a fluorescence-based cellular apoptosis reporter

por Balderstone, Lucy A, Dawson, John C, Welman, Arkadiusz, Serrels, Alan, Wedge, Stephen R, Brunton, Valerie G
Publicado 2019

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways

por Warchal, Scott J., Dawson, John C., Shepherd, Emelie, Munro, Alison F., Hughes, Rebecca E., Makda, Ashraff, Carragher, Neil O.
Publicado 2020

Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients

por Marwick, John A., Elliott, Richard J.R., Longden, James, Makda, Ashraff, Hirani, Nik, Dhaliwal, Kevin, Dawson, John C., Carragher, Neil O.
Publicado 2021

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

por Dawson, John C., Munro, Alison, Macleod, Kenneth, Muir, Morwenna, Timpson, Paul, Williams, Robert J., Frame, Margaret, Brunton, Valerie G., Carragher, Neil O.
Publicado 2021

Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells

por Athanasiadis, Paschalis, Ravikumar, Balaguru, Elliott, Richard J.R., Dawson, John C., Carragher, Neil O., Clemons, Paul A., Johanssen, Timothy, Ebner, Daniel, Aittokallio, Tero
Publicado 2023

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

por Weiss, Jason T., Dawson, John C., Fraser, Craig, Rybski, Witold, Torres-Sánchez, Carmen, Bradley, Mark, Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2014

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

por Weiss, Jason T., Dawson, John C., Macleod, Kenneth G., Rybski, Witold, Fraser, Craig, Torres-Sánchez, Carmen, Patton, E. Elizabeth, Bradley, Mark, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2014

N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture

por Weiss, Jason T., Fraser, Craig, Rubio-Ruiz, Belén, Myers, Samuel H., Crispin, Richard, Dawson, John C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2014

Discovery of senolytics using machine learning

por Smer-Barreto, Vanessa, Quintanilla, Andrea, Elliott, Richard J. R., Dawson, John C., Sun, Jiugeng, Campa, Víctor M., Lorente-Macías, Álvaro, Unciti-Broceta, Asier, Carragher, Neil O., Acosta, Juan Carlos, Oyarzún, Diego A.
Publicado 2023

Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy

por Martello, Andrea, Lauriola, Angela, Mellis, David, Parish, Elisa, Dawson, John C, Imrie, Lisa, Vidmar, Martina, Gammoh, Noor, Mitić, Tijana, Brittan, Mairi, Mills, Nicholas L, Carragher, Neil O, D'Arca, Domenico, Caporali, Andrea
Publicado 2020

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

por Davidson, Callam T., Miller, Eileen, Muir, Morwenna, Dawson, John C., Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P., Homer, Natalie Z. M., Andrew, Ruth, Brunton, Valerie G., Hadoke, Patrick W. F., Walker, Brian R.
Publicado 2023

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity...

por Fraser, Craig, Dawson, John C., Dowling, Reece, Houston, Douglas R., Weiss, Jason T., Munro, Alison F., Muir, Morwenna, Harrington, Lea, Webster, Scott P., Frame, Margaret C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2016