Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease

por De, Suman, Klenerman, David
Publicado 2019

Optical Structural Analysis of Individual α‐Synuclein Oligomers

por Varela, Juan A., Rodrigues, Margarida, De, Suman, Flagmeier, Patrick, Gandhi, Sonia, Dobson, Christopher M., Klenerman, David, Lee, Steven F.
Publicado 2018

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons

por Whiten, Daniel R, Brownjohn, Philip W, Moore, Steven, De, Suman, Strano, Alessio, Zuo, Yukun, Haneklaus, Moritz, Klenerman, David, Livesey, Frederick J
Publicado 2020

Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics

por Schellhaus, Anna Katharina, Moreno-Andrés, Daniel, Chugh, Mayank, Yokoyama, Hideki, Moschopoulou, Athina, De, Suman, Bono, Fulvia, Hipp, Katharina, Schäffer, Erik, Antonin, Wolfram
Publicado 2017

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

por Kundel, Franziska, De, Suman, Flagmeier, Patrick, Horrocks, Mathew H., Kjaergaard, Magnus, Shammas, Sarah L., Jackson, Sophie E., Dobson, Christopher M., Klenerman, David
Publicado 2018

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

por Sang, Jason C., Lee, Ji-Eun, Dear, Alexander J., De, Suman, Meisl, Georg, Thackray, Alana M., Bujdoso, Raymond, Knowles, Tuomas P. J., Klenerman, David
Publicado 2019

Ultrasensitive Measurement of Ca(2+) Influx into Lipid Vesicles Induced by Protein Aggregates

por Flagmeier, Patrick, De, Suman, Wirthensohn, David C., Lee, Steven F., Vincke, Cécile, Muyldermans, Serge, Knowles, Tuomas P. J., Gandhi, Sonia, Dobson, Christopher M., Klenerman, David
Publicado 2017

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

por Whiten, Daniel R., Cox, Dezerae, Horrocks, Mathew H., Taylor, Christopher G., De, Suman, Flagmeier, Patrick, Tosatto, Laura, Kumita, Janet R., Ecroyd, Heath, Dobson, Christopher M., Klenerman, David, Wilson, Mark R.
Publicado 2018

Quantifying Co-Oligomer Formation by α-Synuclein

por Iljina, Marija, Dear, Alexander J., Garcia, Gonzalo A., De, Suman, Tosatto, Laura, Flagmeier, Patrick, Whiten, Daniel R., Michaels, Thomas C. T., Frenkel, Daan, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Publicado 2018

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

por Lee, Ji-Eun, Sang, Jason C., Rodrigues, Margarida, Carr, Alexander R., Horrocks, Mathew H., De, Suman, Bongiovanni, Marie N., Flagmeier, Patrick, Dobson, Christopher M., Wales, David J., Lee, Steven F., Klenerman, David
Publicado 2018

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease

por Sideris, Dimitrios I, Danial, John S H, Emin, Derya, Ruggeri, Francesco S, Xia, Zengjie, Zhang, Yu P, Lobanova, Evgeniia, Dakin, Helen, De, Suman, Miller, Alyssa, Sang, Jason C, Knowles, Tuomas P J, Vendruscolo, Michele, Fraser, Graham, Crowther, Damian, Klenerman, David
Publicado 2021

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

por De, Suman, Wirthensohn, David C., Flagmeier, Patrick, Hughes, Craig, Aprile, Francesco A., Ruggeri, Francesco S., Whiten, Daniel R., Emin, Derya, Xia, Zengjie, Varela, Juan A., Sormanni, Pietro, Kundel, Franziska, Knowles, Tuomas P. J., Dobson, Christopher M., Bryant, Clare, Vendruscolo, Michele, Klenerman, David
Publicado 2019

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

por De, Suman, Whiten, Daniel R., Ruggeri, Francesco S., Hughes, Craig, Rodrigues, Margarida, Sideris, Dimitrios I., Taylor, Christopher G., Aprile, Francesco A., Muyldermans, Serge, Knowles, Tuomas P. J., Vendruscolo, Michele, Bryant, Clare, Blennow, Kaj, Skoog, Ingmar, Kern, Silke, Zetterberg, Henrik, Klenerman, David
Publicado 2019

Inhibiting the Ca(2+) Influx Induced by Human CSF

por Drews, Anna, De, Suman, Flagmeier, Patrick, Wirthensohn, David C., Chen, Wei-Hsin, Whiten, Daniel R., Rodrigues, Margarida, Vincke, Cécile, Muyldermans, Serge, Paterson, Ross W., Slattery, Catherine F., Fox, Nick C., Schott, Jonathan M., Zetterberg, Henrik, Dobson, Christopher M., Gandhi, Sonia, Klenerman, David
Publicado 2017

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

por Whiten, Daniel R., Zuo, Yukun, Calo, Laura, Choi, Minee‐Liane, De, Suman, Flagmeier, Patrick, Wirthensohn, David C., Kundel, Franziska, Ranasinghe, Rohan T., Sanchez, Santiago E., Athauda, Dilan, Lee, Steven F., Dobson, Christopher M., Gandhi, Sonia, Spillantini, Maria‐Grazia, Klenerman, David, Horrocks, Mathew H.
Publicado 2018

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

por Sanderson, John B, De, Suman, Jiang, Haiyang, Rovere, Matteo, Jin, Ming, Zaccagnini, Ludovica, Hays Watson, Aurelia, De Boni, Laura, Lagomarsino, Valentina N, Young-Pearse, Tracy L, Liu, Xinyue, Pochapsky, Thomas C, Hyman, Bradley T, Dickson, Dennis W, Klenerman, David, Selkoe, Dennis J, Bartels, Tim
Publicado 2020

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

por Meng, Jonathan X., Zhang, Yu, Saman, Dominik, Haider, Arshad M., De, Suman, Sang, Jason C., Brown, Karen, Jiang, Kun, Humphrey, Jane, Julian, Linda, Hidari, Eric, Lee, Steven F., Balmus, Gabriel, Floto, R. Andres, Bryant, Clare E., Benesch, Justin L. P., Ye, Yu, Klenerman, David
Publicado 2022

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

por Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publicado 2020

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

por Emin, Derya, Zhang, Yu P., Lobanova, Evgeniia, Miller, Alyssa, Li, Xuecong, Xia, Zengjie, Dakin, Helen, Sideris, Dimitrios I., Lam, Jeff Y. L., Ranasinghe, Rohan T., Kouli, Antonina, Zhao, Yanyan, De, Suman, Knowles, Tuomas P. J., Vendruscolo, Michele, Ruggeri, Francesco S., Aigbirhio, Franklin I., Williams-Gray, Caroline H., Klenerman, David
Publicado 2022

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

por Vilalta, Anna, Zhou, Ye, Sevalle, Jean, Griffin, Jennifer K., Satoh, Kanayo, Allendorf, David H., De, Suman, Puigdellívol, Mar, Bruzas, Arturas, Burguillos, Miguel A., Dodd, Roger B., Chen, Fusheng, Zhang, Yalun, Flagmeier, Patrick, Needham, Lisa-Maria, Enomoto, Masahiro, Qamar, Seema, Henderson, James, Walter, Jochen, Fraser, Paul E., Klenerman, David, Lee, Steven F., St George-Hyslop, Peter, Brown, Guy C.
Publicado 2021