Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy

por Pellegrino, Marsha, Del Bufalo, Francesca, De Angelis, Biagio, Quintarelli, Concetta, Caruana, Ignazio, de Billy, Emmanuel
Publicado 2020

PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches

por Caforio, Matteo, de Billy, Emmanuel, De Angelis, Biagio, Iacovelli, Stefano, Quintarelli, Concetta, Paganelli, Valeria, Folgiero, Valentina
Publicado 2021

CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas

por Cassandri, Matteo, Fioravanti, Rossella, Pomella, Silvia, Valente, Sergio, Rotili, Dante, Del Baldo, Giada, De Angelis, Biagio, Rota, Rossella, Mai, Antonello
Publicado 2020

Innovative and Promising Strategies to Enhance Effectiveness of Immunotherapy for CNS Tumors: Where Are We?

por Quintarelli, Concetta, Camera, Antonio, Ciccone, Roselia, Alessi, Iside, Del Bufalo, Francesca, Carai, Andrea, Del Baldo, Giada, Mastronuzzi, Angela, De Angelis, Biagio
Publicado 2021

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

por Guido, Clara, Baldari, Clara, Maiorano, Gabriele, Mastronuzzi, Angela, Carai, Andrea, Quintarelli, Concetta, De Angelis, Biagio, Cortese, Barbara, Gigli, Giuseppe, Palamà, Ilaria Elena
Publicado 2022

The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors

por Del Baldo, Giada, Del Bufalo, Francesca, Pinacchio, Claudia, Carai, Andrea, Quintarelli, Concetta, De Angelis, Biagio, Merli, Pietro, Cacchione, Antonella, Locatelli, Franco, Mastronuzzi, Angela
Publicado 2023

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing

por Ingegnere, Tiziano, Mariotti, Francesca Romana, Pelosi, Andrea, Quintarelli, Concetta, De Angelis, Biagio, Tumino, Nicola, Besi, Francesca, Cantoni, Claudia, Locatelli, Franco, Vacca, Paola, Moretta, Lorenzo
Publicado 2019

Identification of New Soluble Factors Correlated With the Development of Graft Failure After Haploidentical Hematopoietic Stem Cell Transplantation

por Weber, Gerrit, Strocchio, Luisa, Del Bufalo, Francesca, Algeri, Mattia, Pagliara, Daria, Arnone, Claudia Manuela, De Angelis, Biagio, Quintarelli, Concetta, Locatelli, Franco, Merli, Pietro, Caruana, Ignazio
Publicado 2021

PD‐1‐induced T cell exhaustion is controlled by a Drp1‐dependent mechanism

por Simula, Luca, Antonucci, Ylenia, Scarpelli, Giorgia, Cancila, Valeria, Colamatteo, Alessandra, Manni, Simona, De Angelis, Biagio, Quintarelli, Concetta, Procaccini, Claudio, Matarese, Giuseppe, Tripodo, Claudio, Campello, Silvia
Publicado 2021

WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene

por Montano, Giorgia, Vidovic, Karina, Palladino, Chiara, Cesaro, Elena, Sodaro, Gaetano, Quintarelli, Concetta, De Angelis, Biagio, Errichiello, Santa, Pane, Fabrizio, Izzo, Paola, Grosso, Michela, Gullberg, Urban, Costanzo, Paola
Publicado 2015

FGFR1 is a potential therapeutic target in neuroblastoma

por Cimmino, Flora, Montella, Annalaura, Tirelli, Matilde, Avitabile, Marianna, Lasorsa, Vito Alessandro, Visconte, Feliciano, Cantalupo, Sueva, Maiorino, Teresa, De Angelis, Biagio, Morini, Martina, Castellano, Aurora, Locatelli, Franco, Capasso, Mario, Iolascon, Achille
Publicado 2022

ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

por Tassinari, Valentina, Cesarini, Valeriana, Tomaselli, Sara, Ianniello, Zaira, Silvestris, Domenico Alessandro, Ginistrelli, Lavinia Ceci, Martini, Maurizio, De Angelis, Biagio, De Luca, Gabriele, Vitiani, Lucia Ricci, Fatica, Alessandro, Locatelli, Franco, Gallo, Angela
Publicado 2021

Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

por Polito, Vinicia A., Cristantielli, Rosaria, Weber, Gerrit, Del Bufalo, Francesca, Belardinilli, Tamascia, Arnone, Claudia M., Petretto, Andrea, Antonucci, Laura, Giorda, Ezio, Tumino, Nicola, Pitisci, Angela, De Angelis, Biagio, Quintarelli, Concetta, Locatelli, Franco, Caruana, Ignazio
Publicado 2019

Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma

por Tumino, Nicola, Weber, Gerrit, Besi, Francesca, Del Bufalo, Francesca, Bertaina, Valentina, Paci, Paola, Quatrini, Linda, Antonucci, Laura, Sinibaldi, Matilde, Quintarelli, Concetta, Maggi, Enrico, De Angelis, Biagio, Locatelli, Franco, Moretta, Lorenzo, Vacca, Paola, Caruana, Ignazio
Publicado 2021

GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

por Caforio, Matteo, Sorino, Cristina, Caruana, Ignazio, Weber, Gerrit, Camera, Antonio, Cifaldi, Loredana, De Angelis, Biagio, Del Bufalo, Francesca, Vitale, Alessia, Goffredo, Bianca Maria, De Vito, Rita, Fruci, Doriana, Quintarelli, Concetta, Fanciulli, Maurizio, Locatelli, Franco, Folgiero, Valentina
Publicado 2021

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

por Quintarelli, Concetta, Orlando, Domenico, Boffa, Iolanda, Guercio, Marika, Polito, Vinicia Assunta, Petretto, Andrea, Lavarello, Chiara, Sinibaldi, Matilde, Weber, Gerrit, Del Bufalo, Francesca, Giorda, Ezio, Scarsella, Marco, Petrini, Stefania, Pagliara, Daria, Locatelli, Franco, De Angelis, Biagio, Caruana, Ignazio
Publicado 2018

Establishment and Characterization of a Cell Line (S-RMS1) Derived from an Infantile Spindle Cell Rhabdomyosarcoma with SRF-NCOA2 Fusion Transcript

por Colletti, Marta, Galardi, Angela, Miele, Evelina, Di Paolo, Virginia, Russo, Ida, De Stefanis, Cristiano, De Vito, Rita, Rinelli, Martina, Ciolfi, Andrea, De Angelis, Biagio, Zin, Angelica, Guffanti, Alessandro, Digilio, Maria Cristina, Novelli, Antonio, Alaggio, Rita, Milano, Giuseppe Maria, Di Giannatale, Angela
Publicado 2021

Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies

por Guercio, Marika, Manni, Simona, Boffa, Iolanda, Caruso, Simona, Di Cecca, Stefano, Sinibaldi, Matilde, Abbaszadeh, Zeinab, Camera, Antonio, Ciccone, Roselia, Polito, Vinicia Assunta, Ferrandino, Francesca, Reddel, Sofia, Catanoso, Maria Luigia, Bocceri, Emilia, Del Bufalo, Francesca, Algeri, Mattia, De Angelis, Biagio, Quintarelli, Concetta, Locatelli, Franco
Publicado 2021

Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation

por Perrone, Clara, Pomella, Silvia, Cassandri, Matteo, Pezzella, Michele, Giuliani, Stefano, Gasperi, Tecla, Porrazzo, Antonella, Alisi, Anna, Pastore, Anna, Codenotti, Silvia, Fanzani, Alessandro, Barillari, Giovanni, Conti, Libenzio Adrian, De Angelis, Biagio, Quintarelli, Concetta, Mariottini, Paolo, Locatelli, Franco, Marampon, Francesco, Rota, Rossella, Cervelli, Manuela
Publicado 2023

Crosstalk between Macrophages and Myxoid Liposarcoma Cells Increases Spreading and Invasiveness of Tumor Cells

por Minopoli, Michele, Sarno, Sabrina, Cannella, Lucia, Tafuto, Salvatore, Scognamiglio, Gosuè, Gallo, Michele, Fazioli, Flavio, Azzaro, Rosa, Apice, Gaetano, De Angelis, Biagio, Tamborini, Elena, Garofalo, Cecilia, Pignochino, Ymera, Mercatali, Laura, Ibrahim, Toni, Falcioni, Rita, Valenti, Beatrice, Maestro, Roberta, Scotlandi, Katia, De Chiara, Annarosaria, Carriero, Maria Vincenza
Publicado 2021