Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3

por The, Erlinda, de Graaf, Dennis M., Zhai, Yufeng, Yao, Qingzhou, Ao, Lihua, Fullerton, David A., Dinarello, Charles A., Meng, Xianzhong
Publicado 2022

Circulating interleukin-38 concentrations in healthy adults

por Teufel, Lisa U., de Graaf, Dennis M., Netea, Mihai G., Dinarello, Charles A., Joosten, Leo A. B., Arts, Rob J. W.
Publicado 2022

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

por Marchetti, Carlo, Swartzwelter, Benjamin, Koenders, Marije I., Azam, Tania, Tengesdal, Isak W., Powers, Nick, de Graaf, Dennis M., Dinarello, Charles A., Joosten, Leo A. B.
Publicado 2018

IL‐38 prevents induction of trained immunity by inhibition of mTOR signaling

por de Graaf, Dennis M., Teufel, Lisa U., van de Veerdonk, Frank L., Joosten, Leo A. B., Netea, Mihai G., Dinarello, Charles A., Arts, Rob J. W.
Publicado 2021

A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

por Li, Suzhao, Jiang, Liqiong, Beckmann, Karsten, Højen, Jesper Falkesgaard, Pessara, Ulrich, Powers, Nicholas E., de Graaf, Dennis M., Azam, Tania, Lindenberger, Jared, Eisenmesser, Elan Z., Fischer, Stephan, Dinarello, Charles A.
Publicado 2021

IL-38 Gene Deletion Worsens Murine Colitis

por de Graaf, Dennis M., Wang, Ruth X., Amo-Aparicio, Jesús, Lee, J. Scott, Dowdell, Alexander S., Tengesdal, Isak W., Marchetti, Carlo, Colgan, Sean P., Joosten, Leo A. B., Dinarello, Charles A.
Publicado 2022

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

por Højen, Jesper Falkesgaard, Vindvad Kristensen, Marie Louise, McKee, Amy S., Wade, Megan Taylor, Azam, Tania, Lunding, Lars P., de Graaf, Dennis M., Swartzwelter, Benjamin J., Wegmann, Michael, Tolstrup, Martin, Beckman, Karsten, Fujita, Mayumi, Fischer, Stephan, Dinarello, Charles A.
Publicado 2019

Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients

por de Graaf, Dennis M., Teufel, Lisa U., de Nooijer, Aline H., van Gammeren, Adriaan J., Ermens, Antonius A. M., Gaál, Ildikó O., Crișan, Tania O., van de Veerdonk, Frank L., Netea, Mihai G., Dinarello, Charles A., Joosten, Leo A. B., Arts, Rob J. W.
Publicado 2022

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects

por de Graaf, Dennis M., Jaeger, Martin, van den Munckhof, Inge C. L., ter Horst, Rob, Schraa, Kiki, Zwaag, Jelle, Kox, Matthijs, Fujita, Mayumi, Yamauchi, Takeshi, Mercurio, Laura, Madonna, Stefania, Rutten, Joost H.W., de Graaf, Jacqueline, Riksen, Niels P., van de Veerdonk, Frank L., Netea, Mihai G., Joosten, Leo A.B., Dinarello, Charles A.
Publicado 2020

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

por Tengesdal, Isak W., Menon, Dinoop R., Osborne, Douglas G., Neff, Charles P., Powers, Nicholas E., Gamboni, Fabia, Mauro, Adolfo G., D’Alessandro, Angelo, Stefanoni, Davide, Henen, Morkos A., Mills, Taylor S., De Graaf, Dennis M., Azam, Tania, Vogeli, Beat, Palmer, Brent E., Pietras, Eric M., DeGregori, James, Tan, Aik-Choon, Joosten, Leo A. B., Fujita, Mayumi, Dinarello, Charles A., Marchetti, Carlo
Publicado 2021