RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery

por Lima, Walt F., De Hoyos, Cheryl L., Liang, Xue-hai, Crooke, Stanley T.
Publicado 2016

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

por Liang, Xue-hai, Nichols, Joshua G, De Hoyos, Cheryl L, Crooke, Stanley T
Publicado 2020

Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation

por Shen, Wen, Liang, Xue-hai, Sun, Hong, De Hoyos, Cheryl L., Crooke, Stanley T.
Publicado 2017

Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops

por Shen, Wen, Sun, Hong, De Hoyos, Cheryl L., Bailey, Jeffrey K., Liang, Xue-hai, Crooke, Stanley T.
Publicado 2017

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

por Shen, Wen, De Hoyos, Cheryl L, Sun, Hong, Vickers, Timothy A, Liang, Xue-hai, Crooke, Stanley T
Publicado 2018

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

por Liang, Xue-hai, Sun, Hong, Hsu, Chih-Wei, Nichols, Joshua G, Vickers, Timothy A, De Hoyos, Cheryl L, Crooke, Stanley T
Publicado 2020

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

por Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Publicado 2020

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

por Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Publicado 2019

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

por Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P
Publicado 2021