Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

por Liang, Xue-Hai, Nichols, Joshua G, De Hoyos, Cheryl Li, Sun, Hong, Zhang, Lingdi, Crooke, Stanley T
Publicado 2021

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

por Lima, Walt F., Murray, Heather M., Damle, Sagar S., Hart, Christopher E., Hung, Gene, De Hoyos, Cheryl Li, Liang, Xue-Hai, Crooke, Stanley T.
Publicado 2016

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active...

por Zhang, Lingdi, Liang, Xue-hai, De Hoyos, Cheryl Li, Migawa, Michael, Nichols, Joshua G., Freestone, Graeme, Tian, Jun, Seth, Punit P., Crooke, Stanley T.
Publicado 2022

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

por Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P
Publicado 2021