“Omics” and “epi-omics” underlying the β-cell adaptation to insulin resistance

por De Jesus, Dario F., Kulkarni, Rohit N.
Publicado 2019

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

por Kahraman, Sevim, Shibue, Kimitaka, De Jesus, Dario F, Kim, Hyunki, Hu, Jiang, Manna, Debasish, Wagner, Bridget, Choudhary, Amit, Kulkarni, Rohit N
Publicado 2023

m(6)A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes

por De Jesus, Dario F, Zhang, Zijie, Kahraman, Sevim, Brown, Natalie K, Chen, Mengjie, Hu, Jiang, Gupta, Manoj K, He, Chuan, Kulkarni, Rohit N
Publicado 2019

RADAR: differential analysis of MeRIP-seq data with a random effect model

por Zhang, Zijie, Zhan, Qi, Eckert, Mark, Zhu, Allen, Chryplewicz, Agnieszka, De Jesus, Dario F., Ren, Decheng, Kulkarni, Rohit N., Lengyel, Ernst, He, Chuan, Chen, Mengjie
Publicado 2019

Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia

por St-Louis, Johanna L., El Jellas, Khadija, Velasco, Kelly, Slipp, Brittany A., Hu, Jiang, Helgeland, Geir, Steine, Solrun J., De Jesus, Dario F., Kulkarni, Rohit N., Molven, Anders
Publicado 2023

Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation

por Gupta, Manoj K., De Jesus, Dario F., Kahraman, Sevim, Valdez, Ivan A., Shamsi, Farnaz, Yi, Lian, Swensen, Adam C., Tseng, Yu-Hua, Qian, Wei-Jun, Kulkarni, Rohit N.
Publicado 2018

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation

por Dirice, Ercument, Kahraman, Sevim, Jiang, Wenyu, El Ouaamari, Abdelfattah, De Jesus, Dario F., Teo, Adrian K.K., Hu, Jiang, Kawamori, Dan, Gaglia, Jason L., Mathis, Diane, Kulkarni, Rohit N.
Publicado 2014

E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

por Shirakawa, Jun, Togashi, Yu, Basile, Giorgio, Okuyama, Tomoko, Inoue, Ryota, Fernandez, Megan, Kyohara, Mayu, De Jesus, Dario F., Goto, Nozomi, Zhang, Wei, Tsuno, Takahiro, Kin, Tatsuya, Pan, Hui, Dreyfuss, Jonathan M., Shapiro, A.M. James, Yi, Peng, Terauchi, Yasuo, Kulkarni, Rohit N.
Publicado 2022

Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice

por Wang, Xuanchun, Li, Yanliang, Qiang, Guifen, Wang, Kaihua, Dai, Jiarong, McCann, Maximilian, Munoz, Marcos D., Gil, Victoria, Yu, Yifei, Li, Shengxian, Yang, Zhihong, Xu, Shanshan, Cordoba-Chacon, Jose, De Jesus, Dario F., Sun, Bei, Chen, Kuangyang, Wang, Yahao, Liu, Xiaoxia, Miao, Qing, Zhou, Linuo, Hu, Renming, Ding, Qiang, Kulkarni, Rohit N., Gao, Daming, Blüher, Matthias, Liew, Chong Wee
Publicado 2022

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes

por Dirice, Ercument, Kahraman, Sevim, De Jesus, Dario F., El Ouaamari, Abdelfattah, Basile, Giorgio, Baker, Rocky L., Yigit, Burcu, Piehowski, Paul D., Kim, Mi-Jeong, Dwyer, Alexander J., Ng, Raymond W. S., Schuster, Cornelia, Vethe, Heidrun, Martinov, Tijana, Ishikawa, Yuki, Teo, Adrian Kee Keong, Smith, Richard D., Hu, Jiang, Haskins, Kathryn, Serwold, Thomas, Qian, Wei-Jun, Fife, Brian T., Kissler, Stephan, Kulkarni, Rohit N.
Publicado 2019