A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

por Stoneham, Charlotte A., Langer, Simon, De Jesus, Paul D., Wozniak, Jacob M., Lapek, John, Deerinck, Thomas, Thor, Andrea, Pache, Lars, Chanda, Sumit K., Gonzalez, David J., Ellisman, Mark, Guatelli, John
Publicado 2021

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

por Langer, Simon, Hammer, Christian, Hopfensperger, Kristina, Klein, Lukas, Hotter, Dominik, De Jesus, Paul D, Herbert, Kristina M, Pache, Lars, Smith, Nikaïa, van der Merwe, Johannes A, Chanda, Sumit K, Fellay, Jacques, Kirchhoff, Frank, Sauter, Daniel
Publicado 2019

Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

por Feng, Yongmei, Grotegut, Stefan, Jovanovic, Predrag, Gandin, Valentina, Olson, Steven H., Murad, Rabi, Beall, Anne, Colayco, Sharon, De-Jesus, Paul, Chanda, Sumit, English, Brian P., Singer, Robert H., Jackson, Michael, Topisirovic, Ivan, Ronai, Ze’ev A.
Publicado 2022

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells

por Rines, Daniel R, Gomez-Ferreria, Maria Ana, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, Labow, Marc, Huesken, Dieter, Mickanin, Craig, Hall, Jonathan, Reinhardt, Mischa, Natt, Francois, Lange, Joerg, Sharp, David J, Chanda, Sumit K, Caldwell, Jeremy S
Publicado 2008

Positive Regulation of TRAF6-Dependent Innate Immune Responses by Protein Phosphatase PP1-γ

por Opaluch, Amanda M., Schneider, Monika, Chiang, Chih-yuan, Nguyen, Quy T., Maestre, Ana M., Mulder, Lubbertus C. F., Secundino, Ismael, De Jesus, Paul D., König, Renate, Simon, Viviana, Nizet, Victor, MacLeod, Graham, Varmuza, Susannah, Fernandez-Sesma, Ana, Chanda, Sumit K.
Publicado 2014

A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein

por White, Kris M., De Jesus, Paul, Chen, Zhong, Abreu, Pablo, Barile, Elisa, Mak, Puiying A., Anderson, Paul, Nguyen, Quy T., Inoue, Atsushi, Stertz, Silke, Koenig, Renate, Pellecchia, Maurizio, Palese, Peter, Kuhen, Kelli, García-Sastre, Adolfo, Chanda, Sumit K., Shaw, Megan L.
Publicado 2014

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

por Yin, Xin, Riva, Laura, Pu, Yuan, Martin-Sancho, Laura, Kanamune, Jun, Yamamoto, Yuki, Sakai, Kouji, Gotoh, Shimpei, Miorin, Lisa, De Jesus, Paul D., Yang, Chih-Cheng, Herbert, Kristina M., Yoh, Sunnie, Hultquist, Judd F., García-Sastre, Adolfo, Chanda, Sumit K.
Publicado 2021

Systems-based Analysis of RIG-I-dependent Signaling Identifies KHSRP as an Inhibitor of RIG-I Receptor Activation

por Soonthornvacharin, Stephen, Rodriguez-Frandsen, Ariel, Zhou, Yingyao, Galvez, Felipe, Huffmaster, Nicholas J., Tripathi, Shashank, Balasubramaniam, Vinod RMT, Inoue, Atsushi, de Castro, Elisa, Moulton, Hong, Stein, David A., Sánchez-Aparicio, María Teresa, De Jesus, Paul D., Nguyen, Quy, König, Renate, Krogan, Nevan J., García-Sastre, Adolfo, Yoh, Sunnie M., Chanda, Sumit K.
Publicado 2017

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity

por Pohl, Marie O., Martin-Sancho, Laura, Ratnayake, Ranjala, White, Kris M., Riva, Laura, Chen, Qi-Yin, Lieber, Gauthier, Busnadiego, Idoia, Yin, Xin, Lin, Samuel, Pu, Yuan, Pache, Lars, Rosales, Romel, Déjosez, Marion, Qin, Yiren, De Jesus, Paul D., Beall, Anne, Yoh, Sunnie, Hale, Benjamin G., Zwaka, Thomas P., Matsunaga, Naoko, García-Sastre, Adolfo, Stertz, Silke, Chanda, Sumit K., Luesch, Hendrik
Publicado 2022

Functional landscape of SARS-CoV-2 cellular restriction

por Martin-Sancho, Laura, Lewinski, Mary K., Pache, Lars, Stoneham, Charlotte A., Yin, Xin, Becker, Mark E., Pratt, Dexter, Churas, Christopher, Rosenthal, Sara B., Liu, Sophie, Weston, Stuart, De Jesus, Paul D., O’Neill, Alan M., Gounder, Anshu P., Nguyen, Courtney, Pu, Yuan, Curry, Heather M., Oom, Aaron L., Miorin, Lisa, Rodriguez-Frandsen, Ariel, Zheng, Fan, Wu, Chunxiang, Xiong, Yong, Urbanowski, Matthew, Shaw, Megan L., Chang, Max W., Benner, Christopher, Hope, Thomas J., Frieman, Matthew B., García-Sastre, Adolfo, Ideker, Trey, Hultquist, Judd F., Guatelli, John, Chanda, Sumit K.
Publicado 2021

Discovery of SARS-CoV-2 Antivirals through Large-scale Drug Repositioning

por Riva, Laura, Yuan, Shuofeng, Yin, Xin, Martin-Sancho, Laura, Matsunaga, Naoko, Pache, Lars, Burgstaller-Muehlbacher, Sebastian, De Jesus, Paul D., Teriete, Peter, Hull, Mitchell V., Chang, Max W., Chan, Jasper Fuk-Woo, Cao, Jianli, Poon, Vincent Kwok-Man, Herbert, Kristina M., Cheng, Kuoyuan, Nguyen, Tu-Trinh H., Rubanov, Andrey, Pu, Yuan, Nguyen, Courtney, Choi, Angela, Rathnasinghe, Raveen, Schotsaert, Michael, Miorin, Lisa, Dejosez, Marion, Zwaka, Thomas P., Sit, Ko-Yung, Martinez-Sobrido, Luis, Liu, Wen-Chun, White, Kris M., Chapman, Mackenzie E., Lendy, Emma K., Glynne, Richard J., Albrecht, Randy, Ruppin, Eytan, Mesecar, Andrew D., Johnson, Jeffrey R., Benner, Christopher, Sun, Ren, Schultz, Peter G., Su, Andrew I., García-Sastre, Adolfo, Chatterjee, Arnab K., Yuen, Kwok-Yung, Chanda, Sumit K.
Publicado 2020